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TOP STORIES

Donor Stem Cell Transplant Best for Acute Myeloid Leukemia
People in all risk groups, but especially those with poor and intermediate risk of survival, benefit most, researchers say.

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SCIENCE NEWS

Complimentary Wallchart: Guide to Hematopoietic Colonies Derived from Human Cord Blood Progenitors

Trimming the Fat Boosts Blood Recovery after Marrow Transplant
Researchers at Children's Hospital Boston have discovered that fat cells, which accumulate in bone marrow as people age, inhibit the marrow's ability to produce new blood cells.

Placentas Could be an Important Source of Stem Cells to Fight Disease
Human placenta could be an important source of stem cells for curing leukemia, sickle cell disease and other blood-related disorders, a new study reveals

Landmark Stem Cells Trial Yields Positive Results
The Phase I trial of HuCNS-SC (purified human neural stem cells) conducted at OHSU Doernbecher Children's Hospital included six children with advanced stages of infantile and late-infantile neuronal ceroid lipofuscinosis (NCL), often referred to as Batten disease.

Firm Manufacturing Human Blood
A small Cleveland company may be on the verge of a huge medical breakthrough - artificial human blood. The technique is known as blood pharming and relies upon the creation of an artificial replacement for human bone marrow.

Hybrid Hearts could Solve Transplant Shortage
"Decellularising" hearts, livers and other organs taken either from human cadavers or from larger animals such as pigs, and coating them in stem cells harvested from people, could lead to a virtually limitless supply of organs for transplantation.

New Weapon to Fight Twin Blood Condition
Auckland Hospital in New Zealand is using a laser fetoscope to operate on unborn twins with a blood condition called Twin to Twin Transfusion Syndrome.

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CURRENT PUBLICATIONS

Bone-Marrow Adipocytes as Negative Regulators of the Haematopoietic Microenvironment
Data indicate that antagonizing marrow adipogenesis may enhance haematopoietic recovery in clinical bone-marrow transplantation. [Nature]

Induced Pluripotent Stem Cells Offer New Approach to Therapy in Beta-Thalassemia and Sickle Cell Anemia and Option in Prenatal Diagnosis in Genetic Diseases
Scientists reprogrammed the skin fibroblasts of a patient with homozygous beta-thalassemia into iPS cells, and showed that the iPS cells could be differentiated into hematopoietic cells that synthesized hemoglobin. [PNAS]

Probing the Mitotic History and Developmental Stage of Hematopoietic Cells using Single Telomere Length Analysis (STELA)
Results indicate extensive self-renewal divisions of human hematopoietic stem cells are the primary cause of telomere erosion upon transplantation rather than added cell divisions in downstream progenitors. [Blood]

Cutaneous Lymphocyte Antigen-Positive T cells may Predict the Development of Acute GVHD: Alterations and Differences of CLA+ T- and NK-Cell Fractions
CLA+ T-cell percentage may predict the development of severe aGVHD in clinical settings. [Bone Marrow Transplant]

Therapeutic Effect of Human Umbilical Cord Multipotent Mesenchymal Stromal Cells in a Rat Model of Stroke
UC-MSC transplantation could accelerate neurologic functional recovery of rats after stroke, which may be mediated by their ability to promote angiogenesis. [Transplantation]

Neural Ganglioside GD2 Identifies a Subpopulation of Mesenchymal Stem Cells in Umbilical Cord
Data demonstrate that the cells selected by GD2 are a subpopulation of MSCs with feature of primitive precursor cells and provide evidence that GD2 can be a cell surface marker suitable for the isolation and purification of UC-MSCs in early-passage culture. [Cell Physiol Biochem]

Cord Blood Stem Cell Expansion is Permissive to Epigenetic Regulation and Environmental Cues
Chromatin modifying agent treated, CD34+CD90+ cells were greatly influenced in terms of their degree of expansion, clonogenic potential, cell division rate and transplantability by the combination of cytokines used in culture. [Exp Hematol]

Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia in First Complete Remission
Compared with nonallogeneic SCT therapies, allogeneic SCT has significant RFS and overall survival benefit for intermediate- and poor-risk AML but not for good-risk AML in first complete remission. [J Am Med Assoc]

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INDUSTRY NEWS

Five Cord Blood Transplant Centers in Spain Join Study
The Gamida Cell-Teva Joint Venture announced today that five prestigious cord blood transplantations centers in Spain, three in Barcelona and two in Valencia, have joined the ExCell study.

Biotech Firm Ends Its Offer for Talecris
CSL, an Australian biotechnology firm, said it ended its proposed $3.1 billion acquisition of the Talecris Biotherapeutics Holdings Corporation after the deal was blocked by the Federal Trade Commission.



POLICY NEWS

Obama's Health Plan Needs Spending Controls, Congressional Budget Office Says
Plan to expand health coverage to the uninsured is likely to dig the nation deeper into debt unless policymakers adopt politically painful controls on spending, congressional budget analysts said yesterday.

NIH Receives 20,000 Applications for Challenge Grants Through the Recovery Act
The Challenge Grant program is designed to spur new areas of research and trigger an influx of research dollars into communities across the nation.

Ten Reasons to Make Cord Blood Stem Cells a Public Good
This article presents 10 reasons why Canada needs to create a national public bank for cord blood stem cells.


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