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CURRENT PUBLICATIONS
Acute Graft-Versus-Host Disease Transiently Impairs Thymic Output in Young Patients After Allogeneic Hematopoietic Stem Cell Transplantation
Data show that aGVHD or its treatment has a transient impact on thymic function in younger patients in the first months after HSCT. [Blood]
Impact of HLA Disparity in the Graft-Versus-Host Direction on Engraftment in Adult Patients Receiving Reduced-Intensity Cord Blood Transplantation
HLA disparity plays a significant role in graft-versus-host (GVH) direction in the successful engraftment, raising the novel mechanism responsible for graft failure in CBT. [Blood]
Human Term Placenta as a Source of Hematopoietic Cells
Results suggest that human placenta could become an important new source of hematopoietic cells for allogeneic transplantation.
[Proc Soc Exp Biol Med]
Identification of a Stroma-Mediated Wnt/Beta-Catenin Signal Promoting Self-Renewal of Hematopoietic Stem Cells in the Stem Cell Niche
Wnt/Beta-catenin activated stroma and their cross-talk with HSCs may function as a physiologically regulated microenvironmental cue for HSC self-renewal in the stem cell niche. [Stemcells]
Human Umbilical Cord Mesenchymal Stem Cells Reduce Fibrosis of Bleomycin-Induced Lung Injury
uMSCs have antifibrotic properties and may augment lung repair if used to treat acute respiratory distress syndrome. [Am J Pathol]
Human Fallopian Tube: A New Source of Multipotent Adult Mesenchymal Stem Cells Discarded in Surgical Procedures
Human tube MSCs can be easily isolated, expanded in vitro, present a mesenchymal profile and are able to differentiate into muscle, fat, cartilage and bone in vitro. [J Transl Med]
Increased Programmed Death-1 Molecule Expression in Cytomegalovirus Disease and Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation
An enhanced PD-1 expression during severe aGVHD and with CMV reactivation could explain the known role of aGVHD as a risk factor for CMV disease.
[Biol Blood Marrow Transplant]
Sirolimus as Primary Treatment of Acute Graft-versus-Host Disease following Allogeneic Hematopoietic Cell Transplantation
Primary therapy with sirolimus resulted in durable complete remission of acute graft-versus-host disease (aGVHD) in 50% of patients, without requirement for glucocorticoids.
[Biol Blood Marrow Transplant]
Effects of Mismatching for Minor Histocompatibility Antigens on Clinical Outcomes in HLA-Matched, Unrelated Hematopoietic Stem Cell Transplants
mHAg incompatibility at HA-1, HA-2, HA-3, HA-8, HB-1, and CD31 has no detectable effect on the outcome of HLA matched unrelated donor HSCT. [Biol Blood Marrow Transplant]
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