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TOP STORIES

Study Identifies Benefit of Donor Stem Cell Transplantation for Adults with Acute Myeloid Leukemia
A stem cell transplant (SCT) from a compatible donor early in the course of disease is the best approach for the majority of young and middle-aged adult patients with acute myeloid leukemia (AML), according to a new analysis of two dozen clinical studies.

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SCIENCE NEWS

Arteriocyte Medical Systems in Cleveland Works on Machine to Produce Large Quantities of Artificial Blood
Arteriocyte Medical Systems researchers said they were able to produce blood from stem cells 10 to 100 times faster than with the commonly used techniques with the help of a technology from Nanex, which replicates a bone marrow environment to facilitate the speedy growth of stem cells.
 
Early Heart Attack Therapy with Bone Marrow Extract Improves Cardiac Function
A UCSF study for the treatment of heart failure after heart attack found that the extract derived from bone marrow cells is as effective as therapy using bone marrow stem cells for improving cardiac function, decreasing the formation of scar tissue and improving cardiac pumping capacity after heart attack.

Possible Cure Found for Crohn's Disease
Initial findings from the world's first controlled trial of the procedure have raised hopes that it could banish the disease's symptoms for many years in up to half of the patients who undergo it.

Stem Cell Discovery May Bring Tissue Repair Closer
By studying zebrafish embryos, the research team found BMP4, a protein involved in bone and cartilage development, to be the critical signal required to generate haematopoietic, stem cells in the dorsal aorta.

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CURRENT PUBLICATIONS

microRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells
Findings reveal a previously uncharacterized role for miR-184 in UCB CD4+ T cells and a novel function for microRNA in the early adaptive immune response. [Blood]

Intra-BM Injection to Enhance Engraftment after Myeloablative Umbilical Cord Blood Transplantation with Two Partially HLA-Matched Units
Intra-BM injection (IBMI) of one of two UCB units did not shorten the time to neutrophil engraftment and offers no advantage over conventional double unit transplantation. [Bone Marrow Transplant]

Hepatitis B Virus Reactivation following Allogeneic Hematopoietic Stem Cell Transplantation
HBV reactivation often developed in patients with cGVHD. Liver biopsy was useful in those patients with both to delineate the contribution of each to liver dysfunction. [Biol Blood Marrow Transplant]

Effects of Mismatching for Minor Histocompatibility Antigens on Clinical Outcomes in HLA-Matched, Unrelated Hematopoietic Stem Cell Transplants
mHAg incompatibility at HA-1, HA-2, HA-3, HA-8, HB-1, and CD31 has no detectable effect on the outcome of HLA matched unrelated donor HSCT. [Biol Blood Marrow Transplant]

Increased Programmed Death-1 Molecule Expression in Cytomegalovirus Disease and Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation
Programmed death-1 molecule (PD-1) is induced by aGVHD even in the absence of CMV infection. This enhanced PD-1 expression during severe aGVHD and with CMV reactivation could explain the known role of aGVHD as a risk factor for CMV disease. [Biol Blood Marrow Transplant]

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INDUSTRY NEWS

MaRS Innovation Selects Umbilical Cord Stem Cell Technology from Samuel Lunenfeld Research Institute of Mount Sinai Hospital as its First Commercialization Opportunity
MaRS Innovation and the Samuel Lunenfeld Research Institute of Mount Sinai Hospital have entered into an agreement to collaboratively initiate commercialization of an umbilical cord stem cell technology for potential treatment in cardiovascular disease, diabetes and neurological disorders.

Bio-Matrix Scientific Group Targets Hospitals Needing Cord Blood Storage
Bio-Matrix Scientific Group, Inc. announced today the launch of a national marketing program aimed at hospitals in need of storing umbilical cord blood specimens for future transplantation.

Stanbio Laboratory Receives FDA Approval for HemoPoint(R) H2 Data Management System
Stanbio Laboratory, L.P. is pleased to announce the FDA approval of its HemoPoint(R) H2 Hemoglobin Data Management System (DMS).

Immucor: FDA Could Pull Manufacturing License
Immucor Inc., which makes products used in blood transfusions, said Friday the Food and Drug Administration intends to revoke the company's biologics manufacturing license, citing a January inspection.



POLICY NEWS

Blood Samples Raise Questions of Privacy
A group of parents are challenging Minnesota's practice of storing babies' blood samples and allowing researchers to study them without their permission. The confrontation has focused attention on the practice at a time when there is increasing interest in using millions of these collected "blood spots" to study diseases.

Canada: Top Court Rules Transfusion Law Constitutional
Seriously-ill children under 16 can be forced to take life-saving medical treatment against their wishes - but only after their maturity and viewpoint has been carefully considered, the Supreme Court of Canada ruled today.


NIH

Findings of Research Misconduct

CBER

510(k) Blood Establishment Computer Software

BK960004 - Defense Blood Standard System (DBSS)


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