|
CURRENT PUBLICATIONS
Human Term Placenta a New Abundant Source of Hematopoietic Cells-A Potent Alternative for Cord Blood and Bone Marrow
Cells derived from placental tissue were shown to differentiate into all blood lineages in vitro. Animal experiments further demonstrated successful engraftment of placenta-derived HSC, which reconstituted hematopoiesis in immunodeficient mice. [Exp Biol Med]
Functional Unresponsiveness and Replicative Senescence of Myeloid Leukemia Antigen-specific CD8+ T Cells after Allogeneic Stem Cell Transplantation
Circulating leukemia-specific CD8+ T cells are prominent in myeloid leukemia patients after HSCT, but such cells are largely functionally unresponsive, most likely due to replicative senescence.
[Clin Cancer Res]
Surface Antigen Phenotypes of Hematopoietic Stem Cells from Embryos and Murine Embryonic Stem Cells
Unique phenotype signifies a developmentally immature population of cells with features of both primitive and mature HSC. [Blood]
Partially Matched Related Donor Transplantation Can Achieve Outcomes Comparable with Unrelated Donor Transplantation for Patients with Hematologic Malignancies
Comparisons show that every major end point, including relapse, non-relapse mortality, overall survival, and leukemia-free survival, was comparable between the partially matched related donors and the unrelated groups. [Clin Cancer Res]
Cyclin A Is Redundant in Fibroblasts but Essential in Hematopoietic and Embryonic Stem Cells
Cyclin A, the first cyclin ever cloned, is thought to be an essential component of the cell-cycle engine. Authors tested the requirement for cyclin A function using conditional knockout mice lacking both testis-specific cyclin A1 and ubiquitously expressed cyclin A2. [Cell]
A Novel Immunoregulatory Protein in Human Colostrum, Syntenin-1, for Promoting the Development of IgA-Producing Cells From Cord Blood B cells
This study demonstrated that levels of syntenin-1 in colostrum were correlated with IgA-inducing activities, and recombinant syntenin-1 could induce preferentially IgA production from naive B cells. [Int Immunol]
Unrelated Donor Umbilical Cord Blood Transplantation in Pediatric Myelodysplastic Syndrome: A Single-Center Experience
Pediatric patients with myelodysplastic syndromes were transplanted with unrelated donor umbilical cord blood and results were equivalent to published matched allogeneic bone marrow data. [J Clin Oncol]
Stroma-Free Mass Production of Clinical-Grade Red Blood Cells by Using Poloxamer 188 as an RBC Survival Enhancer
This RBC production protocol is a simple stroma- and serum-free culture method ensuring enhanced viability of terminally mature erythroid cells and can be easily applicable to mass production of clinical-grade RBCs as well as erythropoiesis research. [Transfusion]
| 
