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TOP STORIES

Study Promises Faster Recovery from Life-Threatening Blood Cell Shortages
A key compound resupplies bone marrow with fast-acting stem cells that can more quickly rekindle blood cell production, according to a study published online today in the journal Blood. [University of Rochester Medical Center, Rochester]

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SCIENCE NEWS

CORD BLOOD PROFICIENCY TESTING: Standardize Your Hematopoietic Colony-Forming Cell (CFC) Assays with the PT Program

'Bubble' Children Treatment Hope
Children seriously ill because their immune systems have genetic flaws could have their lives saved by a safer form of bone marrow transplant, doctors say. [Great Ormond Street Hospital, London]

Study Identifies Protein's Important Role in Stem Cell Process
The ability to use stem cell therapies in the fight against illnesses like diabetes, Parkinson's or Alzheimer's disease, took a small but significant step as Cambridge scientists uncovered a key process that makes them pluripotent - the remarkable ability to transform into any of the body's different cell types. [Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge]

One Factor is Sufficient - Even in Human Cells
After successful experiments with murine cells, German researchers have now reprogrammed human somatic cells with a single factor. [Max Planck Institute for Molecular Biomedicine, Munster]

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CURRENT PUBLICATIONS

Definitive Proof for Direct Reprogramming of Hematopoietic Cells to Pluripotency
This paper shows definitive proof of direct reprogramming of murine hematopoietic cells with no rearranged genes. [Blood]

Expanding Multiviral Reactive T cells from Cord Blood
A novel method to rapidly expand polyclonal populations of viral reactive CTLs from naive cord blood T cells that target CMV, adenovirus, and EBV. [Blood]

Functionally Active Virus-Specific T cells that target CMV, Adenovirus, and EBV can be Expanded from Naive T-cell Populations in Cord Blood and will Target a Range of Viral Epitopes
It is possible to generate trivirus-specific peripheral blood-derived virus-specific cytotoxic T lymphocytes
(CTLs) in a single culture of CB, which may be of value to prevent or treat viral disease in CB transplant recipients. [Blood]

The Notch Ligands Jagged2, Delta1, and Delta4 Induce Differentiation and Expansion of Functional Human NK Cells from CD34+ Cord Blood Hematopoietic Progenitor Cells
Notch ligands have differential ability to induce and expand immature, but functional, NK cells from CD34+ HPCs. The use of Notch ligands to generate functional NK cells in vitro may be significant for cellular therapy purposes. [Biol Blood Marrow Transplant]

Umbilical Cord Wharton's Jelly: A New Potential Cell Source of Mesenchymal Stromal Cells for Bone Tissue Engineering
The similar characteristics of bone morphogenetic protein 2-induced (BMP2) osteogenic differentiation of Umbilical cord-derived MSCs (UCMSCs) and bone marrow-derived mesenchymal stromal cells (BMSCs) in vitro would support the use of UCMSCs in tissue-engineered bone. [Tissue Eng Part A]

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INDUSTRY NEWS

STEMCELL Technologies Inc. to Host Stem Cell Training Courses
STEMCELL's fall training program includes includes 2-day courses on mesenchymal stem cell biology, mammary stem cell biology, neural stem cell biology, hematopoietic stem cell biology, and human embryonic and induced pluripotent stem cell biology.

European Consortium Gets $427,000 to Develop Technology, Protocols for Handling Blood Samples
A consortium headed by Swedish sample-preparation firm Denator has received ???300,000 ($427,000) from the EU Eurostars Programme to improve the handling of human blood plasma samples with the aim of advancing discovery of blood-based protein biomarkers.



POLICY NEWS

New York Commits $20.4M to Stem Cell Research

Governor David Paterson said $5.4 million would earmarked to recruit research fellows and transition them into research institutions in New York.

NATIONAL INSTITUTES OF HEALTH (United States)

New Reporting and Assurance Requirements for Institutions Receiving Awards for Training of Graduate Students for Doctoral Degrees (NOT-OD-09-141)


Two Critical Issues for Recent Submissions of Applications for Ruth L. Kirschstein National Research Service Awards (NRSA) Individual Fellowships References and Designation of Sponsor (NOT-OD-09-144)

xTrain Expands to Include Use for NIH Institutional Career Development Awards and NLM Training Grants (NOT-OD-09-146)

Request for Applications: 2010 NIH Directors New Innovator Award Program (DP2) (RFA-RM-09-011)

Request for Applications: Institutional Clinical and Translational Science Award (U54) (RFA-RM-09-019)


FOOD AND DRUG ADMINISTRATION (United States)

Announcement of Office of Management and Budget Approval; Guidance for Industry on Formal Dispute Resolution; Appeals Above the Division Level

Food and Drug Administration Transparency Task Force; Reopening of Comment Period until November 6, 2009

Office of the Commissioner Reorganization; Statement of Organizations, Functions, and Delegations of Authority




Events

XXXVI Annual Meeting of the European Society for Artificial Organs 2009   
September 2-5, 2009
Compiègne, France

16th International Society of Developmental Biologists Congress
September 6-10, 2009
Edinburgh, United Kingdom

International Society for Hematology and Stem Cells 38th Annual Scientific Meeting
September 9-12, 2009
Athens, Greece

51st ASH Annual Meeting and Exposition
December 9-12, 2009
New Orleans, LA

2010 BMT Tandem Meetings
February 24-28, 2010
Orlando, Florida

The European Group for Blood & Marrow Transplantation Annual Meeting
March 21-24, 2010
Vienna, Austria

Canadian Blood and Marrow Transplant Consortium Annual Meeting
April 7-10, 2010
Vancouver, BC

16th Annual International Society for Cellular Therapy Meeting
May 22-26, 2010
Philadelphia, Pennsylvania

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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