TOP STORIES

ex Vivo Expansion of Human Hematopoietic Stem Cells by a Small-molecule Agonist of c-MPL
In this study, the researchers evaluated the effects of NR-101, a novel small-molecule c-MPL agonist, on the ex vivo expansion of human cord blood hematopoietic stem cells. [Exp Hematol]

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SCIENCE NEWS

Stem Cell Therapy May Offer Hope for Acute Lung Injury
Researchers have shown that adult stem cells from bone marrow can prevent acute lung injury in a mouse model of the disease. [University of Illinois at Chicago College of Medicine, Chicago]

Roche Molecular Systems Research Team Uses 454 Sequencing System for High-Resolution HLA Genotyping
Researchers have used high-throughput sequencing technology from 454 Life Sciences, a Roche Company, to carry out high-resolution human leukocyte antigen genotyping in research samples, important in minimizing the risk of graft rejection and graft versus host disease. [454 Life Sciences, Branford]

CURRENT PUBLICATIONS

Loss of the Rho GTPase Activating Protein p190-B Enhances Hematopoietic Stem Cell Engraftment Potential
In this paper, the researchers show that loss of p190-B RhoGTPase activating protein, a negative regulator of Rho GTPases, results in enhanced long-term engraftment during serial transplantation. [Blood]

Pluripotency can be Rapidly and Efficiently Induced in Human Amniotic Fluid-derived Cells
This study reports for the first time rapid and efficient generation of iPS cells from human amniotic fluid-derived cells via ectopic expression of four human factors: OCT4/SOX2/KLF4/C-MYC. [Hum Mol Genet]

Bilateral Interaction Between Cord Blood-Derived Human Neural Stem Cells and Organotypic Rat Hippocampal Culture
As a simplified alternative to in vivo transplantation in this work the researchers have applied a long-term organotypic rat hippocampal slice culture as a recipient tissue to study bilateral graft/host cells interactions ex vivo. [Stem Cells Dev]

Umbilical Cord Mesenchymal Stem Cells: Role of Regulatory Genes in Their Differentiation to Osteoblasts
In this study, the researchers describe the gene regulation of umbilical cord mesenchymal stem cells' differentiation to osteogenic, adipogenic, and chondrogenic precursors and demonstrate their tendency to differentiate toward the osteoblast lineage. [Stem Cells Dev]

Short-Term Culture of Umbilical Cord Blood-Derived CD34 Cells Enhances Engraftment into NOD/SCID Mice through Increased CXCR4 Expression
Here, the researchers demonstrate the effect of short-term culture on CXCR4 expression on umbilical CB-derived CD34+ cells and subsequent engraftment capability in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. [Stem Cells Dev]

Cell Viability During Platelet Storage in Correlation to Cellular Metabolism After Different Pathogen Reduction Technologies
The objective of this study was to evaluate if pathogen reduction technologies affect platelet viability by alteration of PLT metabolism during storage. [Transfusion]

INDUSTRY NEWS

European Biotech Company Biocell Center Opens First U.S. Facility for Preservation of Amniotic Stem Cells in Medford, Massachusetts
European biotechnology company Biocell Center, announced recently that it is expanding its tissue bank and research operations to serve families, medical centers and scientists in the United States.

Officials Behind Plan to Shut Blood Services in Saint John Offer a Compromise
If a blood stock-holding unit stays in the city, Saint John will be in a better position than ever to access blood products, say officials from Canadian Blood Services.

Blood Stays Chilled with New Tracking Service
The device monitors the temperature and GPS-tracked location of human tissue every second during transport, ensuring it stays in the best possible condition.

POLICY NEWS

CIRM, the UK and Canada Award more than $250 Million to Accelerate the Pace of Bringing Stem Cell Therapies to the Clinic
The California Institute for Regenerative Medicine, the state stem cell agency, and two international partners awarded more than $250 million to 14 multidisciplinary teams of researchers in California, the UK and Canada to develop stem cell-based therapies for 11 diseases.

Guidance for Industry: An Acceptable Circular of Information for the Use of Human Blood and Blood Components, October 2009

Public Workshop: Emerging Arboviruses: Risk Assessment for Blood, Cell, Tissue and Organ Safety

EVENTS

National Marrow Donor Program 2009 Council Meeting
November 5-7, 2009
Minneapolis, Minnesota

51st ASH Annual Meeting and Exposition
December 9-12, 2009
New Orleans, Louisiana

2010 BMT Tandem Meetings
February 24-28, 2010
Orlando, Florida

The European Group for Blood & Marrow Transplantation Annual Meeting
March 21-24, 2010
Vienna, Austria

Canadian Blood and Marrow Transplant Consortium Annual Meeting
April 7-10, 2010
Vancouver, British Columbia

16th Annual International Society for Cellular Therapy Meeting
May 22-26, 2010
Philadelphia, Pennsylvania 

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