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TOP STORIES

Placental Precursor Stem Cells Require Testosterone-free Environment to Survive
Trophoblast stem cells, cells found in the layer of peripheral embryonic stem cells from which the placenta is formed, are thought to exhibit "immune privilege" that aids cell survivability and is potentially beneficial for cell and gene therapies. [University of South Florida, Tampa]

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SCIENCE NEWS

NOXXON Announces Initiation of First-in-Human Clinical Trial with Hematopoietic Stem Cell Mobilizing Spiegelmer® NOX-A12
NOXXON Pharma AG, announced today the successful initial dosing of healthy volunteers in a first-in-human clinical trial with Spiegelmer® NOX-A12. [NOXXON Pharma AG, Berlin]

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CURRENT PUBLICATIONS

Infectious Complications after Unrelated Umbilical Cord Blood Transplantation in Adult Patients with Hematologic Malignancies
This retrospective study assessed infectious complications occurring in adult patients after umbilical cord blood transplantation. [Biol Blood Marrow Transplant]

A "No-wash" Albumin-Dextran Dilution Strategy for Cord Blood Unit Thaw: High Rate of Engraftment and a Low Incidence of Serious Infusion Reactions
Cord blood thaw with albumin-dextran dilution reduces unit manipulation, and minimizes cell loss, speeds time to infusion, is associated with a tolerable infusion reaction profile, and a high rate of sustained engraftment in cord blood transplant recipients less than 20 kg. [Biol Blood Marrow Transplant]

Human Late Memory CD8+ T Cells Have a Distinct Cytokine Signature Characterized by CC Chemokine Production without IL-2 Production
Late memory T cell skewing is observed in the setting of immune recovery after cord blood transplantation, and may be associated with inferior control of viral reactivation and cancers. [J Immunol]

Autologous Umbilical Cord Blood Transfusion in Very Young Children With Type 1 Diabetes
Researchers conducted an open-label phase I study using autologous umbilical cord blood infusion to ameliorate type 1 diabetes. [Diabetes Care]

Individual and Combined Effects of Mesenchymal Stromal Cells and Recombinant Stimulatory Cytokines on the In Vitro Growth of Primitive Hematopoietic Cells from Human Umbilical Cord Blood
Mesencymal stem cells seem to play a key role, particularly on more primitive (CD34+ CD38- Lin-) cells, only in the absence of cytokines or the presence of early-acting cytokines. When both early- and late-acting cytokines are present in culture, MSC seem to be unnecessary for optimal development of CFC and CD34+ cells. [Cytotherapy]

New Approaches for Improving Engraftment After Cord Blood Transplantation
This article discusses factors that are of crucial importance in circumventing the problem of delayed engraftment after umbilical cord blood transplantation. [Biol Blood Marrow Transplant]


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INDUSTRY NEWS

Stem Cell Therapy International, Inc. and Histostem Korea Announce Providing Hematopoietic Stem Cell to Queen Mary Hospital, Hong Kong
Stem Cell Therapy International Inc. and its soon to be subsidiary, Histostem Ltd. of South Korea, announced that they recently supplied hematopoietic stem cells to The Queen Mary Hospital of the University of Hong Kong, China, for treatment of Leukemia patients.

StemEx(R) Noted as a Reliable Investigational Product of an Expanded Population of Stem Cells at Umbilical Cord Blood Symposium in Israel
At a recent symposium entitled Umbilical Cord Blood: An Alternative for Bone Marrow Transplantation in Adults, bone marrow transplantation experts addressed participants on the current challenges presented by bone marrow transplantation and the importance of investigating cord blood as an alternative source for treating patients with leukemia and lymphoma.

Stem Cell Therapy Maker Aldagen Files for IPO
Stem cell drug developer Aldagen Inc. on Wednesday filed a registration for a planned initial public offering, and valued the potential IPO at $80.5 million.




POLICY NEWS

Springs Man Joins Fight to Allow Compensation for Bone-marrow Donors
Whether bone marrow is classified as an organ, as it's medically classified, or a bodily fluid, is at the heart of a lawsuit by a group hoping to bring more bone marrow donors to the table by being able to compensate them.




EVENTS

National Marrow Donor Program 2009 Council Meeting
November 5-7, 2009
Minneapolis, Minnesota

51st ASH Annual Meeting and Exposition
December 9-12, 2009
New Orleans, Louisiana

2010 BMT Tandem Meetings
February 24-28, 2010
Orlando, Florida

The European Group for Blood & Marrow Transplantation Annual Meeting
March 21-24, 2010
Vienna, Austria

Canadian Blood and Marrow Transplant Consortium Annual Meeting
April 7-10, 2010
Vancouver, British Columbia

16th Annual International Society for Cellular Therapy Meeting
May 22-26, 2010
Philadelphia, Pennsylvania 



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