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CURRENT PUBLICATIONS
CCR5 Ligands Modulate CXCL12-Induced Chemotaxis, Adhesion, and Akt Phosphorylation of Human Cord Blood CD34+ Cells
CXCL12 and its receptor CXCR4 play an important role in hematopoietic stem/progenitor cell (HSPC) migration from and retention within the bone marrow. In addition to CXCR4, HSPCs express receptors for various other chemokines; which were examined in this study. [J Immunol]
Toxic Effects of Low Doses of Bisphenol-A on Human Placental Cells
Bisphenol-A (BPA) is extensively used in a broad range of products including baby bottles, food-storage containers, medical equipment, and consumer electronics. Thus the toxic effects of BPA concentrations, close to levels found in serum of pregnant women on human cytotrophoblasts, were investigated. [Toxicol Appl Pharmacol]
Infectious Complications after Unrelated Umbilical Cord Blood Transplantation in Adult Patients with Hematologic Malignancies
This retrospective study assessed infectious complications occurring in adult patients after umbilical cord blood transplantation. [Biol Blood Marrow Transplant]
Unrelated Cord Blood Transplantation in Pediatric Patients: A Report from Saudi Arabia
Until recently, Saudi Arabia did not have a national unrelated cord blood (UCB) bank. In this study, researchers report their experience in UCB transplantation in children using units procured from western cord blood banks. [Bone Marrow Transplant]
Mercury and Heavy Metal Profiles of Maternal and Umbilical Cord Red Blood Cells in a Japanese Population
Mercury and other heavy metal profiles, namely, lead, arsenic, cadmium, and selenium were investigated in maternal and umbilical cord red blood cells at parturition in a Japanese population. [Ecotoxicol Environ Saf]
Cord Blood Mesenchymal Stem Cells Propel Human Dendritic Cells to an Intermediate Maturation State and Boost Interleukin-12 Production by Mature Dendritic Cells
Researchers have identified an immature mesenchymal stem cell population in umbilical cord blood that remarkably, modulated dendritic cells in a different way. [Immunology]
Post-Transplant EBV-Related Lymphoproliferative Disorder Complicating Umbilical Cord Blood Transplantation in Patients of Adrenoleukodystrophy
Two cases in the unrelated umbilical cord blood transplantation (UCBT) setting were reported and the following new information was added to the literature: (i) EBV-related post-transplant lymphoproliferative disorder (PTLD) can be presented late in recipients of unrelated UCBT; (ii) in contrast to reported literatures that PTLD is a serious complication with unfavorable outcome, especially in monomorphic form, their cases showed that the clinical course may be relatively benign if treatment is initiated promptly. [Pediatr Blood Cancer]
bFGF Enhances the IGFs-Mediated Pluripotent and Differentiation Potentials in Multipotent Stem Cells
It has widely been reported that basic fibroblast growth factor (bFGF) promotes proliferation of human stem cells and contributes to the maintenance of their self-renewal capability through repeated replications. In contrast to embryonic stem cells, the effects of growth factors on adult stem cells are poorly understood, however, and were investigated in this paper. [Growth Factors]
Polymorphonuclear Leukocytes Isolated from Umbilical Cord Blood as a Useful Research Tool to Study Adherence to Cell Monolayers
To evaluate whether polymorphonuclear leukocytes (PMN) isolated from umbilical cord blood could be used for in vitro experiments to monitor neutrophil adherence, researchers compared the adherence to confluent endothelial and epithelial cell monolayers using PMN isolated from umbilical cord and adult peripheral blood. [J Immunol Methods]
Optimization of Isolation and Further Characterization of Umbilical Cord Blood-Derived Very Small Embryonic/Epiblast-Like Stem Cells
To preserve umbilical cord blood (UCB)-derived very small embryonic/epiblast-like stem cells (VSELs) in final umbilical cord blood preparations, the(remove 'the') researchers propose a relatively short and economical three-step isolation protocol that allows recovery of approximately 60% of the initial number of Lin-/CD45-/CD133+ UCB-VSELs present in freshly harvested UBC(use this abbreviation here) units. [Eur J Haematol]
Percutaneous Transplantation of Human Umbilical Cord Blood-Derived Multipotent Stem Cells in a Canine Model of Spinal Cord Injury
A method for percutaneous transplantation of human umbilical cord blood-derived multipotent stem cells under fluoroscopic guidance is described. [J Neurosurg Spine]
Middle-Term Expansion of Hematopoietic Cord Blood Cells with New Human Stromal Cell Line Feeder-Layers and Different Cytokine Cocktails
Stromal components and soluble factors, such as cytokines, can be useful to induce in vitro cell expansion. Hense, feeder-layers from new stromal cell lines and different exogenous cytokine cocktails induce HSC expansion in middle-term cultures were investigated. [Int J Mol Med]
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