CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Viral Fibroblast Growth Factor, Matrix Metalloproteases, and Caspases are Associated with Enhancing Systemic Infection by Baculoviruses
Researchers describe an elegant mechanism mediated by a baculovirus-encoded fibroblast growth factor that signals a previously undescribed stepwise cascade of protease activation wherein matrix metalloproteases activate effector caspases, leading to remodeling of basal lamina lining tracheal cells associated with the intestine and culminating in the establishment of efficient systemic infections. [Proc Natl Acad Sci U S A]

Tetraspanin CD151 Regulates Growth of Mammary Epithelial Cells in Three-Dimensional Extracellular Matrix: Implication for Mammary Ductal Carcinoma In Situ
Depletion of CD151 suppressed growth of HB2 cells, a nontumorigenic breast epithelial cell line, in 3D extracellular matrices and in Matrigel-based xenografts. [Cancer Res]

Dynamic Shape Changes of Extracellular Matrix-Producing Cells Drive Morphogenesis of Ball-And-Socket Joints in the Fly Leg
The results highlight the importance of dynamic cell behaviors in precise shaping of skeletal extracellular matrix architecture. [Development]

Bone Regeneration Mediated by Biomimetic Mineralization of a Nanofiber Matrix
Researchers report here on the use of self-assembling peptide nanostructured gels to promote bone regeneration that have the capacity to mineralize in biomimetic fashion. [Biomaterials]

Bioprinting Vessel-Like Constructs Using Hyaluronan Hydrogels Crosslinked with Tetrahedral Polyethylene Glycol Tetracrylates
Biofabrication of cell suspensions in tetra-acrylate derivative synthetic extracellular matrices demonstrates the feasibility of building bioartificial blood vessel-like constructs for research and potentially clinical uses. [Biomaterials]

Interconnected Macroporous Poly(Ethylene Glycol) (PEG) Cryogels as a Cell Scaffold for Cartilage Tissue Engineering
Results indicated that interconnected macroporous PEG cryogels successfully supported attachment, viability, proliferation, and biosynthetic activity of seeded chondrocytes. [Tissue Eng Part A]

Tissue Engineering by Molecular Disassembly and Reassembly: Biomimetic Retention of Mechanically Functional Aggrecan in Hydrogel
By altering the assembly of proteoglycan (PG) aggregates with hyaluronan with or without link proteins, which affects aggrecan retention, it may be possible to achieve the targeted levels of PG components in order to modulate the mechanical properties of the engineered construct for cartilage as well as other tissues containing PG and PG aggregates. [Tissue Eng Part C Methods]

An Effective Targeted Nanoglobular Manganese(II) Chelate Conjugate for Magnetic Resonance Molecular Imaging of Tumor Extracellular Matrix
In this study, a CLT1 peptide targeted G3 nanoglobular Mn(II)-DOTA monoamide conjugate was designed and synthesized as a targeted MRI contrast agent for molecular imaging of the fibrin-fibronectin complexes or oncofetal fibronectin in tumor stroma. [Mol Pharm]

Hyperglycemic Conditions Modulate Connective Tissue Reorganization by Human Vascular Smooth Muscle Cells through Stimulation of Hyaluronan Synthesis
High glucose concentration stimulated hyaluronan synthesis by vascular smooth muscle cells and modulated their ability to reorganize collagen-rich matrix. [Glycobiology]

Altered Fibroblast Proteoglycan Production in COPD
This study explores the hypothesis that altered depositions of proteoglycans in COPD lungs, and in particular versican and perlecan, is a result of dysregulated fibroblast proteoglycan production. [Respir Res]

INDUSTRY NEWS

National Institute of Standards and Technology Will Use 3D Biotek's 3D Scaffold Product as the Basis for a Reference Material
The National Institute of Standards and Technology will use 3D Biotek, LLC's polycaprolactone (PCL) scaffolds, 3D Insert™ -- PCL, as Reference 3D Tissue Scaffolds. [3D Biotek, LLC Press Release]

Kensey Nash Receives FDA 510(k) Clearance for ECM Product, Meso BioMatrix Surgical Mesh
Kensey Nash Corporation announced that it has received 510(k) clearance from the U.S. Food and Drug Administration for its second extracellular matrix (ECM) product, the Meso BioMatrix™ product. [Kensey Nash Corporation Press Release]

McGowan Institute for Regenerative Medicine Awarded $12 Million Contract to Support Human Studies of Novel Treatments for Battlefield Injuries and Scars
A two-year, $12 million contract with the U.S. Department of Defense Office of Technology Transition (OTT) will jumpstart human trials of three innovative research programs that aim to replace scars and defects with healthy, functional tissues. [University of Pittsburgh Medical Center Press Release]

Rensselaer Polytechnic Institute Wins $2.45 Million Grant to Support Stem Cell Research
Rensselaer Polytechnic Institute and principal investigator Glenn Monastersky have been awarded a four-year $2.45 million grant from the New York Stem Cell Science Program of the Empire State Stem Cell Board. [Rensselaer Polytechnic Institute Press Release]

Maryland Stem Cell Research Commission Announces 42 Projects for Funding
The Maryland Stem Cell Research Commission has completed its evaluation of the 141 applications in response to its three official Requests for Applications during the FY 2010 funding cycle. [Maryland Stem Cell Research Commission Press Release]

HHMI Awards $79 Million for Science Education to Research Universities, Top Scientists
Howard Hughes Medical Institute (HHMI) announced new grants totaling $79 million that will help universities strengthen undergraduate and precollege science education nationwide. [Howard Hughes Medical Institute Press Release]

Pfizer to Cut 6,000 Jobs, Close Eight Plants
Pfizer Inc. plans to eliminate 6,000 manufacturing jobs over the next 18 months to five years as it closes eight plants and reduces operations at six others. [St. Louis Business Journal] 

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