Effects of Extracellular Matrix Protein Functionalized Fluid Membrane on Cell Adhesion and Matrix Remodeling 
In order to study cellular responses and extracellular matrix protein remodeling mediated by biomaterials coating, researchers proposed a biomimetic construct containing protein-conjugated supported lipid bilayers as a cell culture platform. [Biomaterials]

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Novel Molecular Pathway Regulates Invasive Growth and Metastasis in Estrogen Receptor-Positive Breast Cancer
The investigators demonstrated that over-expression of Rab27B in non-invasive breast cancer cell lines promoted cell cycle progression, proliferation and invasiveness of breast cancer cells in vitro . Mass spectrometry identified HSP90-alpha, a chaperone molecule, as a key pro-invasive growth regulator that was secreted in a Rab27B-dependent fashion into the micro-environment and was required for the activation of matrix metallo proteinase-2. [Press release from ScienceDaily discussing online prepublication in the Journal of the National Cancer Institute]

Growing Cells Without Scaffolds
Cell sheet technology is an alternative, scaffold-free tissue-engineering strategy, which aims at sheet-like cell aggregation with cell-to-cell connections and with an extracellular matrix while eliminating the disadvantages of scaffold materials. [Press release from Materials Views discussing online prepublication in Macromolecular Bioscience]

Living, Breathing Human Lung-on-a-Chip: A Potential Drug-Testing Alternative
Researchers have created a device that mimics a living, breathing human lung on a microchip. [Press release from the Wyss Institute for Biologically Inspired Engineering at Harvard University discussing online prepublication in Science]

CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Reconstituting Organ-Level Lung Functions on a Chip
Researchers describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. [Science]

Effect of the Secretory Small GTPase Rab27B on Breast Cancer Growth, Invasion, and Metastasis
Secretory GTPases like Rab27B control vesicle exocytosis and deliver critical proinvasive growth regulators into the tumor microenvironment. The expression and role of Rab27B in breast cancer were unknown. [J Natl Cancer Inst]

Alpha2Beta1 Integrin Controls Association of Rac with the Membrane and Triggers Quiescence of Endothelial Cells
Here, researchers show that alpha2beta1 integrin, when ligated to the basement membrane component laminin-1, triggers a proliferation arrest in primary endothelial cells. [J Cell Sci]

Matrix Metalloproteinase 2 (MMP-2) Degrades Soluble Vasculotropic Amyloid-Beta E22Q and L34V Mutants Delaying Their Toxicity for Human Brain Microvascular Endothelial Cells
The results indicate that endogenous MMP-2 release and activation resulting from amyloid challenge differentially degrades amyloid-beta species, delaying their toxicity for endothelial cells. [J Biol Chem]

Interaction Between Electrical Stimulation, Protein Coating and Matrix Elasticity: a Complex Effect on Muscle Fibre Maturation
Previously, researchers showed the effects of matrix stiffness and protein coating on proliferation and differentiation of muscle progenitor cells in a two-dimensional (2D) situation. In the present study, researchers have investigated the additional effect of electrical stimulation. [J Tissue Eng Regen Med]

Carrier-Free Epithelial Cell Sheets Prepared by Enzymatic Degradation of Collagen Gel
In this study, researchers developed a novel method for preparing carrier-free epithelial cell sheets, which have potential for use in repairing defects of the ocular surface. [J Tissue Eng Regen Med]

A Simple Method for Cell Sheet Fabrication Using Mica Surfaces Grafted with Peptide Detergent A6K
Cell sheet technology is a very important strategy for scaffold-free tissue engineering. In order to fabricate cell sheets by a simple method, peptide detergent A6K was grafted on mica surfaces by dropping its aqueous solution at different concentrations on the surface. [Macromol Biosci]

Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem Cell Differentiation and Tissue Formation
Findings support the utility of acellular lung as a matrix for engineering lung tissue and highlight the critical role played by matrix or scaffold-associated cues in guiding embryonic stem cell differentiation toward lung-specific lineages. [Tissue Eng Part A]

BIND Biosciences Secures $12.4 Million Financing
BIND Biosciences, Inc. announced that it has secured a $12.4 Million Series C-1 financing. [BIND Biosciences, Inc. Press Release]

BioMimetic Therapeutics Receives Filing Letter from FDA for Augment™ Bone Graft PMA
BioMimetic Therapeutics, Inc. announced the Food & Drug Administration (FDA) has accepted for review its Premarket Approval (PMA) application for Augment™ Bone Graft for use in foot and ankle fusions in the U.S. The FDA has now filed the application and begun the comprehensive review of the clinical module. [BioMimetic Therapeutics, Inc. Press Release]

Coinjection of Halozyme's rHuPH20 Enzyme Accelerates the Absorption and Action of Mealtime Insulin Analogs
Halozyme Therapeutics, Inc. announced clinical trial results showing that the addition of its proprietary rHuPH20 (recombinant human hyaluronidase, PH20) enzyme to three different mealtime insulin analogs accelerated their absorption. [Halozyme Therapeutics, Inc. Press Release]
 

Research Budgets Face Austerity in 2012
The National Institutes of Health and other life sciences and biomedical research funding agencies will need to trim their budgets for 2012, which are to be planned over the summer, to satisfy a White House that is now stressing deficit reduction and belt-tightening after two years of stimulus funding-boosted research budgets. [The Office of Management and Budget, United States]

The Reality of Human Stem Cell Research in Europe
A new report from the European Science Foundation examines the key scientific questions for human stem cell research in the context of the rapidly emerging field of regenerative medicine. [European Science Foundation, European Union]

Strong Medicine for French Research
The medical-research adviser to France's president aims to shift power and money to universities. [National Research Agency, France]

Cutting Drug Prices Hampers New Development
A report by the European School of Management and Technology Competition Analysis, and commissioned by the drugmaker Novartis, said there was a direct link between strict regulation and low innovation in the sector. [Reuters]

Meeting of the National Advisory Council for Healthcare Research and Quality [Agency for Healthcare Research and Quality, United States]

Maryland Stem Cell Research Commission - Public Meeting Notice [Maryland Stem Cell Research Commission, United States]

American Society for Matrix Biology (ASMB) 2010 Biennial Meeting
October 24-27, 2010
Charleston, United States

Select Biosciences 2nd Annual Lab-on-a-Chip World Congress
October 28-29, 2010
San Diego, United States

Fraunhofer Life Science Symposium 2010
October 29-30, 2010
Leipzig, Germany

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

Medica 2010
November 17-20, 2010
Dusseldorf, Germany

Translational Excellence in Regenerative Medicine - Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

Tissue Engineering & Regenerative Medicine International Society (TERMIS) - North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

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