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CURRENT PUBLICATIONS
Generation of Medaka Fish Haploid Embryonic Stem Cells
Here, the researchers generated gynogenetic medaka embryos and obtained three haploid ES cell lines, elusive for culture that retained pluripotency and competitive growth. [Science]
Human Embryonic Stem Cell Lines Derived from Single Blastomeres of Two 4-cell Stage Embryos
To investigate potency at the 4-cell stage, this study aimed to derive pluripotent human embryonic stem cells from single blastomeres. [Hum Reprod]
Inhibition of Caspase-mediated Anoikis is Critical for bFGF-sustained Culture of Human Pluripotent Stem Cells
By using the defined mTeSR1 medium and collecting freshly detached cells, the researchers found here that human pluripotent stem cells including embryonic stem cells and induced pluripotent stem cells are subject to constant anoikis in culture. [JBC]
Identification of Targets of Prox1 During in Vitro Vascular Differentiation from Embryonic Stem Cells: Functional Roles of HoxD8 in Lymphangiogenesis
This study identified FoxC2 and angiopoietin-2 (Ang2), which play important roles in the maturation of lymphatic vessels, as novel targets of Prox1 in mouse embryonic-stem-cell-derived endothelial cells. [J Cell Sci]
HOXB4-Transduced Embryonic Stem Cell-Derived Lin-c-kit+ and Lin-Sca-1+ Hematopoietic Progenitors Express H60 and Are Targeted by NK Cells1
In this study, the researchers demonstrate that hematopoietic progenitor cells derived from mouse ES cells ectopically expressing HOXB4 fail to engraft long-term in the presence of NK cells. [J Immunol]
Gene Silencing in Human Embryonic Stem Cells by RNA Interference
The prospects of combining RNAi and HESC manipulation for both basic research and future therapies are reviewed. [Biochem Biophys Res Commun]
Cripto-1 Is Required for Hypoxia to Induce Cardiac Differentiation of Mouse Embryonic Stem Cells
In the present study, the effect of low levels of oxygen, which occurs naturally in rapidly growing tissues, on Cripto-1 expression in mouse embryonic stem cells and in human embryonal carcinoma cells was investigated. [Am J Pathol]
p75 Neurotrophin Receptor is Involved in Proliferation of Undifferentiated Mouse Embryonic Stem Cells
In the present work the researchers investigated the expression of p75NTR and Trks in totipotent and pluripotent cells, the mouse pre-implantation embryo and embryonic stem and germ cells. [Exp Cell Res]
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