LABORATORY RESEARCH

Systemic Signals Regulate Ageing and Rejuvenation of Blood Stem Cell Niches
Scientists show that age-associated changes in stem cell supportive niche cells deregulate normal hematopoiesis by causing hematopoietic stem cell dysfunction. [Nature]

Gli1 Regulates the Proliferation and Differentiation of Hematopoietic Stem Cells and Myeloid Progenitors
Researchers have analyzed hematopoietic stem cell (HSC) and progenitor function in mice with a homozygous deletion of Gli1 (Gli1null). Gli1null mice have more long-term HSC that are more quiescent and show increased engraftment after transplantation. [Blood]

Notch Signaling Distinguishes Two Waves of Definitive Hematopoiesis in the Zebrafish Embryo
Scientists examine whether embryonic specification of erythromyeloid progenitors requires Notch signaling as has been shown for hematopoietic stem cells. [Blood]

Expression Map of the Human Exome in CD34+ Cells and Blood Cells: Increased Alternative Splicing in Cell Motility and Immune Response Genes
Using Human Exon ST 1.0 microarrays, the entire exome expression profile of immature CD34+ hematopoietic stem and progenitor cells and mature whole blood cells was mapped, compared to a collection of solid tissues and made freely available as an online exome expression atlas. [PLoS ONE]

RAD 001 (Everolimus) Prevents mTOR and Akt Late Re-Activation in Response to Imatinib in Chronic Myeloid Leukemia
The rapamycin derivative RAD 001 (everolimus, Novartis Institutes for Biomedical Research) inhibits mammalian target of rapamycin (mTOR) and, more importantly, revokes mTOR late re-activation in response to imatinib mesylate. [J Cell Biochem]

Chemotherapy-Induced Mesenchymal Stem Cell Damage in Patients with Hematological Malignancy
The phenotype and functional properties of marrow mesenchymal stem cells derived from untreated and chemotherapeutically treated patients with hematological malignancy were compared. [Ann Hematol]

CLINICAL RESEARCH

Gemtuzumab Ozogamicin as Postremission Treatment in Acute Myeloid Leukemia at 60 Years of Age or More: Results of a Multicenter Phase III Study
Postremission treatment with gemtuzumab ozogamicin in acute myeloid leukemia at older age does not provide benefits regarding any of the clinical endpoints. [Blood]

Investigation of Murine Spleen as a Niche for Hematopoiesis
The presence of endogenous hematopoietic progenitors in spleen was investigated by transplanting intact spleen into allotype-distinct recipients and monitoring development of progeny cells in grafted tissues. [Transplantation]

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2010 Bone Marrow Transplant (BMT) Tandem Meetings
February 24-28, 2010
Orlando, United States

36th Annual Meeting of the European Group for Blood & Marrow Transplantation (EBMT)
March 21-24, 2010
Vienna, Austria

12th Biennial Canadian Blood and Marrow Transplant Group (CBMTG) Conference
April 7-10, 2010
Vancouver, Canada

American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

XXXIst International Congress of the International Society of Blood Transfusion (ISBT) in joint cooperation with the 43rd Congress of the German Society for Transfusion Medicine and Immunohematology (DGTI)
June 26-July 1, 2010
Berlin, Germany

Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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Research & Development Scientist - Pancreatic Cell Biology (STEMCELL Technologies)

Research & Development Scientist - Endothelial Cell Biology (STEMCELL Technologies)

Research & Development Scientist - Epithelial Cell Biology (STEMCELL Technologies)

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