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CURRENT PUBLICATIONS
LABORATORY RESEARCH
A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo
Researchers combined computer-aided drug design with functional assays to identify low-molecular-weight compounds that bind to the corepressor binding groove of the BCL6 BTB domain. [Cancer Cell]
Sp1/NF(Kappa)B/HDAC/miR-29b Regulatory Network in KIT-Driven Myeloid Leukemia
Here, researchers show that KIT mutations lead to MYC -dependent miR-29b repression and increased levels of the miR-29b target Sp1 in KIT-driven leukemia. [Cancer Cell]
Tel1/ETV6 Specifies Blood Stem Cells through the Agency of VEGF Signaling
Researchers show that the leukemia-associated Ets transcription factor, Tel1/ETV6, specifies the first hematopoietic stem cells in the dorsal aorta. [Dev Cell]
Adenosine A2A Receptor Agonists and PDE Inhibitors: A Synergistic Multi-Target Mechanism Discovered Through Systematic Combination Screening in B-Cell Malignancies
Researchers discovered an unexpected synergistic interaction between adenosine receptor agonists and phosphodiesterase inhibitiors that displays substantial activity in a panel of multiple myeloma (MM) and diffuse large B cell lymphoma cell lines and tumor cells from MM patients. [Blood]
Elevated IL-17 Produced by TH17 Cells Promotes Myeloma Cell Growth and Inhibits Immune Function in Multiple Myeloma
As IL-6 and TGF-beta are important for the generation of TH17 cells, researchers observed a significantly elevated baseline and induced frequency of TH17 cells in peripheral blood and bone marrow mononuclear cells from multiple myeloma patients compared to healthy donors. [Blood]
Positioning of Bone Marrow Hematopoietic and Stromal Cells Relative to Blood Flow In Vivo : Serially Reconstituting Hematopoietic Stem Cells Reside in Distinct Non-Perfused Niches
Researchers report that the position of phenotypic hematopoietic stem cells, multipotent and myeloid progenitors relative to blood flow, follows a hierarchy reflecting differentiation stage whereas mesenchymal stem cells are perivascular. [Blood]
Array-Based Genomic Resequencing of Human Leukemia
To identify oncogenes in leukemias, researchers performed large-scale resequencing of the leukemia genome using DNA sequence arrays that determine approximately 9 Mbp of sequence corresponding to the exons or exon-intron boundaries of 5648 protein-coding genes. [Oncogene]
CLINICAL RESEARCH
Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group
The Microarray Innovations in Leukemia study assessed the clinical utility of gene expression profiling as a single test to subtype leukemias into conventional categories of myeloid and lymphoid malignancies. [J Clin Oncol]
Anemia in Hodgkin's Lymphoma: The Role of Interleukin-6 and Hepcidin
Cytokines play a pivotal role in Hodgkin's lymphoma (HL). Because interleukin-6 induces expression of hepcidin, one of the principal regulators of iron metabolism, researchers studied the contribution of hepcidin in anemia in HL at diagnosis. [J Clin Oncol]
Vaccination With Synthetic Analog Peptides Derived from WT1 Oncoprotein Induces T Cell Responses in Patients with Complete Remission from Acute Myeloid Leukemia
A pilot study was undertaken to assess the safety, activity and immunogenicity of a polyvalent WT1 peptide vaccine in patients with acute myeloid leukemia in complete remission but with molecular evidence of WT1 transcript. [Blood]
Long-Term Outcomes After Hematopoietic SCT for Adult T Cell Leukemia/Lymphoma: Results of Prospective Trials
This is the first report to clarify the long-term outcomes after a reduced-intensity conditioning regimen for adult T cell leukemia/lymphoma patients. [Bone Marrow Transplant]
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EVENTS
16th International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States
International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States
XXXIst International Congress of the International Society of Blood Transfusion (ISBT) in joint cooperation with the 43rd Congress of the German Society for Transfusion Medicine and Immunohematology (DGTI)
June 26-July 1, 2010
Berlin, Germany
Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia
American Association of Blood Banks (AABB) Annual Meeting 2010
October 9-12, 2010
Baltimore, United States
52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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