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SCIENCE NEWS
Drinking While Pregnant Tied to Rare Leukemia in Offspring
Pregnant woman may have another reason to avoid drinking, with a new study finding that alcohol use during pregnancy ups the risk for a rare blood cancer in children. [Press release from Yahoo! discussing online prepublication in Cancer Epidemiology, Biomarkers & Prevention]
Leukaemia Busters Scientists Make Research Breakthrough
Scientists working in The Simon Flavell Leukaemia Research Laboratory at Southampton General Hospital have made a breakthrough discovery on how to increase the potency of immunotoxin treatment by over one million-fold for certain types of leukemia and lymphoma. [Leukaemia Busters Press Release]
Anemia Drugs Hold Dangers for Kidney Patients
The powerful drugs used to fight anemia caused by kidney failure increase the risk for cardiovascular problems such as heart attack, a major study has found. [Press release from Bloomberg Businessweek discussing online prepublication in Annals of Internal Medicine]
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CURRENT PUBLICATIONS (Ranked by Impact Factor)
LABORATORY RESEARCH
Live Imaging of Runx1 Expression in the Dorsal Aorta Tracks the Emergence of Blood Progenitors from Endothelial Cells
By time-lapse microscopy of Runx1-enhanced green fluorescent protein transgenic zebrafish embryos, researchers were able to capture a subset of cells within the ventral endothelium of the dorsal aorta, as they acquire hemogenic properties, and directly emerge as presumptive hematopoietic stem cells. [Blood]
Opposing Roles of Polycomb Repressive Complexes in Hematopoietic Stem and Progenitor Cells
Researchers have investigated the role of polycomb repressive complexes in hematopoietic stem cells and progenitor populations. [Blood]
Methylation and Silencing of miRNA-124 by EVI1 and Self-Renewal Exhaustion of Hematopoietic Stem Cells in Murine Myelodysplastic Syndrome
Here, researchers show that a double point mutant EVI1-(1+6Mut), unable to bind Gata1, abrogates the onset of myelodysplastic syndrome in the mouse and re-establishes normal megakaryopoiesis, erythropoiesis, bone marrow function, and peripheral blood profiles. [Proc Natl Acad Sci U S A]
Modeling Reveals Bistability and Low-Pass Filtering in the Network Module Determining Blood Stem Cell Fate
The analysis not only reveals new insights into hematopoietic stem cell regulatory network functionality but also provides a novel and widely applicable strategy to incorporate experimental measurements into dynamical network models. [PLoS Comput Biol]
Expression of a Src-Family Kinase in CML Cells Induces Resistance to Imatinib in a Kinase-Dependent Manner
Here researchers tested whether Hck overexpression is sufficient to induce imatinib resistance using both wild-type Hck and a mutant (Hck-T338A) that is uniquely sensitive to the pyrazolo-pyrimidine inhibitor, NaPP1. [J Biol Chem]
Protein Arginine Methyltransferase 1 Suppresses Megakaryocytic Differentiation Via Modulation of the p38 Mitogen-Activated Protein Kinase Pathway in K562 Cells
Researchers propose modulation of the p38 MAP kinase pathway by protein arginine methyltransferase 1 as a novel mechanism regulating megakaryocytic differentiation. This study thus provides a new perspective on the promotion of megakaryopoiesis. [J Biol Chem]
CLINICAL RESEARCH
Prognostic Significance of CEBPA Mutations in a Large Cohort of Younger Adult Patients With Acute Myeloid Leukemia: Impact of Double CEBPA Mutations and the Interaction With FLT3 and NPM1 Mutations
The purpose of this study was to determine the clinical relevance of mutations in the CCAAT/enhancer binding protein alpha (CEBPA) gene in acute myeloid leukemia and to examine factors that might modify prognostic impact. [J Clin Oncol]
Cytogenetics of Childhood Acute Myeloid Leukemia: United Kingdom Medical Research Council Treatment Trials AML 10 and 12
This cytogenetic study of 729 childhood patients classified them into 22 subgroups and evaluated their incidence and risk of childhood acute myeloid leukemia. [J Clin Oncol]
Deletions of the Derivative Chromosome 9 Do Not Influence the Response and the Outcome of Chronic Myeloid Leukemia in Early Chronic Phase Treated With Imatinib Mesylate: GIMEMA CML Working Party Analysis
To investigate the prognostic value of der(9) deletions in early chronic-phase chronic myeloid leukemia (CML), researchers performed an analysis of three prospective imatinib trials of the Italian Group for Hematological Malignancies of the Adult (GIMEMA) CML Working Party. [J Clin Oncol]
A Novel Prognostic Model in Elderly Patients with Acute Myeloid Leukemia - Results of 909 Patients Entered into the Prospective AML96 Trial
Researchers present an analysis of potential prognostic factors derived from a large multicenter trial performed in patients with acute myeloid leukemia older than 60 years. [Blood]
Extent of Alcohol Consumption among Adult Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study
This study aimed to identify subgroups of childhood cancer survivors at highest risk of consuming alcohol, consuming above recommended weekly levels, and consuming potentially harmful amounts and compare survivor risks with those expected from the general population. [Cancer Epidemiol Biomarkers Prev]
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EVENTS
Stem Cells, Tissue Homeostasis and Cancer Conference
May 12-15, 2010
Heidelberg, Germany
16th International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States
Systems Biology of Stem Cells
May 24-25, 2010
Irvine, United States
International Symposium, Stem Cells in Biology and Disease
May 26-28, 2010
Lisbon, Portugal
International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States
XXXIst International Congress of the International Society of Blood Transfusion (ISBT) in joint cooperation with the 43rd Congress of the German Society for Transfusion Medicine and Immunohematology (DGTI)
June 26-July 1, 2010
Berlin, Germany
The European Molecular Biology Organization (EMBO) Meeting 2010
September 4-7, 2010
Barcelona, Spain
Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States
Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia
Stem Cells and Regeneration
October 3-9, 2010
Woods Hole, United States
American Association of Blood Banks (AABB) Annual Meeting 2010
October 9-12, 2010
Baltimore, United States
Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany
52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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