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TOP STORY
Babraham Scientists Discover a New Mechanism Behind Leukemia 
New research revealed that mice missing two key genes develop an aggressive form of leukemia similar to acute lymphoblastic leukemia, the most common form of leukemia in children. [Press release from the Babraham Institute discussing online prepublication in Nature Immunology]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH
Deletion of the RNA-Binding Proteins ZFP36L1 and ZFP36L2 Leads to Perturbed Thymic Development and T Lymphoblastic Leukemia
Here, researchers show that mice that lacked ZFP36L1 and ZFP36L2 during thymopoiesis developed a T cell acute lymphoblastic leukemia-dependent on the oncogenic transcription factor Notch1. [Nat Immunol]
Wnt/Ca2+/NFAT Signaling Maintains Survival of Ph+ Leukemia Cells Upon Inhibition of Bcr-Abl
To identify genes whose inhibition sensitizes Bcr-Abl+ leukemias to killing by Bcr-Abl inhibitors, researchers performed an RNAi-based synthetic lethal screen with imatinib mesylate in chronic myeloid leukemia cells. [Cancer Cell]
PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3 p88
Researchers demonstrate that upon As2O3 exposure, PML undergoes reactive oxygen species-initiated intermolecular disulfide formation and binds arsenic directly. [Cancer Cell]
Gene Amplification as Double Minutes or Homogeneously Staining Regions in Solid Tumors: Origin and Structure
In the present paper researchers investigated 10 cell lines from solid tumors showing MYCN amplification as double minutes or homogeneously staining regions. [Genome Res]
Immune Activation Induces Immortalization of HTLV-1 LTR-Tax Transgenic CD4+ T Cells
Researchers suggest that immune activation of infected CD4+ T cells plays an important role in the induction of Tax expression, T cell proliferation, and pathogenesis of adult T cell leukemia/lymphoma in HTLV-1-infected individuals. [Blood]
CD34+ Cells from AML with Mutated NPM1 Harbor Cytoplasmic Mutated Nucleophosmin and Generate Leukemia in Immunocompromised Mice
This study provides further evidence that NPM1 mutation is a founder genetic lesion and has potential implications for the cell-of-origin and targeted therapy of NPM1-mutated acute myeloid leukemia (AML). [Blood]
Drosophila Abelson Kinase Mediates Cell Invasion and Proliferation Through Two Distinct MAPK Pathways
Using the Drosophila wing epithelium as an in vivo model system, researchers show that overexpression (activation) of Drosophila Abl (dAbl) causes loss of epithelial apical/basal cell polarity and secretion of matrix metalloproteinases, resulting in a cellular invasion and apoptosis. [Oncogene]
CLINICAL RESEARCH
Therapy-Related Myeloid Neoplasms in Patients With Acute Promyelocytic Leukemia Treated With All-Trans-Retinoic Acid and Anthracycline-Based Chemotherapy
Researchers analyzed the incidence, risk factors, and outcome of therapy-related myeloid neoplasms in patients with acute promyelocytic leukemia in first complete remission. [J Clin Oncol]
Hematopoietic Stem Cell Transplantation for Acute Leukemia in Relapse or Primary Induction Failure
Hematopoietic stem cell transplantation when a patient is not in complete remission is of uncertain benefit. Researchers hypothesized that pretransplantation variables may define subgroups that have a better prognosis. [J Clin Oncol]
Prognostic Impact of Minimal Residual Disease in CBFB-MYH11-Positive Acute Myeloid Leukemia
The purpose of this study is to evaluate the prognostic impact of minimal residual disease in patients with acute myeloid leukemia expressing the CBFB-MYH11 fusion transcript. [J Clin Oncol]
Induction of Complete and Molecular Remissions in Acute Myeloid Leukemia by Wilms' Tumor 1 Antigen-Targeted Dendritic Cell Vaccination
Here, in a phase I/II trial, researchers investigated the effect of autologous dendritic cell vaccination in 10 patients with acute myeloid leukemia. [Proc Natl Acad Sci U S A]
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POLICY NEWS
Ireland Keeps Light Shining on Science with New Spending
In a surprise move, the Irish government (which is tottering on the brink of bankruptcy) announced that it would inject 359 million Euros into research. [Programme for Reseach in Third-Level Institutions, Ireland]
Russian Researchers Call for Better Coordination of Science
More than 2200 researchers sent an open letter to Russian President Dmitry Medvedev last week asking the government to set Russian science in order and to consult with the scientific community when making major science-policy decisions. [Russia]
"Game Over" for British Science?
The Royal Society and the British Academy strongly warned the British government that looming cuts to science funding could be "irreversibly catastrophic for the future of U.K. science and economic growth" if they go too far. [The Royal Society and the British Academy, United Kingdom]
House Panel Approves 3.2% Raise for NIH in 2011
A House of Representatives spending panel yesterday approved a $1 billion increase, to $32 billion, in the 2011 budget for the National Institutes of Health (NIH). [National Institutes of Health, United States]
NIH Expands National Network for Transforming Clinical and Translational Research
Nine health research centers have received funds to develop ways to reduce the time it takes for clinical research to become treatments for patients. The funds were awarded as part of the Clinical and Translational Science Awards program which is led by the National Center for Research Resources. [National Institutes of Health, United States]
Prospective Grant of Exclusive License: The Development of Human Therapeutics for the Treatment of Cancer [National Institutes of Health, United States]
Pre-Application Meeting for Request for Applications (RFA-CA-10-016) for the Clinical Proteomic Technologies for Cancer Initiative (CPTC): Proteome Characterization Centers (NOT-CA-10-031) [National Institutes of Health, United States]
Notice of Intent to Publish a Request for Applications for Tumor Microenvironment Network (TMEN) (NOT-CA-10-032) [National Institutes of Health, United States]
Clarification of Additional Research Objectives for NICHD PAR-08-138, Genetic Screens to Enhance Zebrafish Research (R01) (NOT-HD-10-015) [National Institutes of Health, United States]
Notice of Expiration of Biomedical Technology Research Resource (PAR-08-259) and Reissuance of Biomedical Technology Research Center (P41)(PAR-10-225) (NOT-RR-10-011) [National Institutes of Health, United States]
2011 NIH Directors New Innovator Award Program (DP2) (RFA-RM-10-009) [National Institutes of Health, United States]
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EVENTS (Listed by Date)
Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland
Select Biosciences 2nd Annual World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland
Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland
The European Molecular Biology Organization (EMBO) Meeting 2010
September 4-7, 2010
Barcelona, Spain
International Society for Cellular Therapy (ISCT) - Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy
Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States
Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia
Sickle Cell Disease Association of America (SCDAA) 38th Annual Convention
September 21-24, 2010
Washington D.C., United States
American Society of Hematology (ASH) State-of-the-Art Symposium 2010
September 24-25, 2010
Chicago, United States
Society for the Advancement of Blood Management® (SABM®) 2010 Annual Meeting
September 24-26, 2010
San Juan, Puerto Rico
Stem Cells and Regeneration
October 3-9, 2010
Woods Hole, United States
American Association of Blood Banks (AABB) Annual Meeting 2010
October 9-12, 2010
Baltimore, United States
Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany
52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States
NEW Highlights of American Society of Hematology (ASH) Vancouver
January 21-22, 2011
Vancouver, Canada
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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