TOP STORY

Researchers Discover That One Type of Stem Cell Creates a Niche for Another Type Within Bone Marrow  
Researchers report that hematopoietic stem cells (HSCs) retain their unique features in response to signals from another stem cell population, mesenchymal stem cells, which create a supportive bone marrow niche for the HSCs. [Press release from Cold Spring Harbor Laboratory discussing online prepublication in Nature]

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Researchers Use Stem Cells to Treat Children with Life-Threatening, Blistering Skin Disease
University of Minnesota physician-researchers have demonstrated that a lethal skin disease can be successfully treated with stem cell therapy. [Press release from the University of Minnesota discussing online prepublication in the New England Journal of Medicine]

Jackson Researchers Find Single-Gene Culprit for Blood Diseases
Researchers discovered that the mouse mutant Nan, a model for severe inherited anemia, carries a single-gene mutation, but one that selectively interferes with a cascade of events critical to normal red blood cell formation. [Press release from The Jackson Laboratory discussing online prepublication in the Proceedings of the National Academy of Sciences]

Scientists Map Epigenetic Changes During Blood Cell Differentiation
Having charted the occurrence of a common chemical change that takes place while stem cells decide their fates and progress from precursor to progeny, a Johns Hopkins-led team of scientists has produced the first-ever epigenetic landscape map for tissue differentiation. [Press release from EurekAlert! discussing online prepublication in Nature]

Synthetic Blood Breakthrough After Scientists 'Produce Red Cells from IVF Embryos'
Red blood cells have been created from spare IVF embryos cells for the first time in Britain, as part of a multi-million pound project to manufacture synthetic blood on an industrial-scale, scientists said. [Telegraph Press Release]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Mesenchymal and Hematopoietic Stem Cells Form a Unique Bone Marrow Niche
Results uncover an unprecedented partnership between two distinct somatic stem-cell types and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs. [Nature]

Comprehensive Methylome Map of Lineage Commitment from Haematopoietic Progenitors
The results directly demonstrate that modulation of DNA methylation occurs during lineage-specific differentiation and defines a comprehensive map of the methylation and transcriptional changes that accompany myeloid versus lymphoid fate decisions. [Nature]

Vascular Remodeling of the Vitelline Artery Initiates Extra-Vascular Emergence of Hematopoietic Clusters
The vitelline artery is a temporary structure that undergoes extensive remodeling during mid-gestation to eventually become the superior mesenteric artery (also called the cranial mesenteric artery, in the mouse). Here researchers show that during this remodeling process, large clusters of hematopoietic progenitors emerge via extra-vascular budding, and form structures that resemble previously described mesenteric blood islands. [Blood]

The B-Cell Tumor Associated Antigen ROR1 can be Targeted with T-cells Modified to Express a ROR1-Specific Chimeric Antigen Receptor
The receptor tyrosine kinase-like orphan receptor 1 (ROR1) was identified as a highly expressed gene in B-cell chronic lymphocytic leukemia, but not normal B-cells, suggesting it may serve as a tumor-specific target for therapy. Researchers analyzed ROR1-expression in normal nonhematopoietic and hematopoietic cells including B-cell precursors, and in hematopoietic malignancies. [Blood]

Severe Anemia in the Nan Mutant Mouse Caused by Sequence-Selective Disruption of Erythroid Krüppel-Like Factor
Studies of mouse models of anemia have long provided fundamental insights into red blood cell formation and function. Here researchers show that the semidominant mouse mutation Nan ("neonatal anemia") carries a single amino acid change (E339D) within the second zinc finger of the erythroid Krüppel-like factor, a critical erythroid regulatory transcription factor. [Proc Natl Acad Sci]

Comprehensive MicroRNA Expression Profiling of the Hematopoietic Hierarchy
Here, researchers report the development and application of a high-throughput microfluidic real-time quantitative PCR approach for generating global miRNA profiles for 27 phenotypically distinct cell populations isolated from normal adult mouse hematopoietic tissues. [Proc Natl Acad Sci]

Trisomic Dose of Several Chromosome 21 Genes Perturbs Haematopoietic Stem and Progenitor Cell Differentiation in Down's Syndrome
Using the transchromosomic system (mouse embryonic stem cells) bearing an extra human chromosome 21 (HSA21), researchers analyzed the early stages of haematopoietic commitment (mesodermal colony formation) in vitro. [Oncogene]

ZFP36L1 Negatively Regulates Erythroid Differentiation of CD34+ Hematopoietic Stem Cells by Interfering with Stat5b Pathway
ZFP36L1 is a member of a family of CCCH tandem zinc finger proteins (TTP family) able to bind to AU-rich elements in the 3'-untranslated region of mRNAs, thereby triggering their degradation. The present study suggests that such mechanism is used during hematopoiesis to regulate differentiation by post-transcriptionally modulating the expression of specific target genes. [Mol Biol Cell]

CLINICAL RESEARCH

Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa
Recessive dystrophic epidermolysis bullosa is an incurable, often fatal mucocutaneous blistering disease caused by mutations in COL7A1,  the gene encoding type VII collagen (C7). On the basis of preclinical data showing biochemical correction and prolonged survival in col7 -/- mice, researchers hypothesized that allogeneic marrow contains stem cells capable of ameliorating the manifestations of recessive dystrophic epidermolysis bullosa in humans. [New England Journal of Medicine]

The Impact of HLA Matching on Long-Term Transplant Outcome after Allogeneic Hematopoietic Stem Cell Transplantation for CLL: A Retrospective Study from the EBMT Registry
Researchers analyzed 368 chronic lymphocytic leukemia patients who underwent allogeneic hematopoietic stem cell transplantation reported to the EBMT registry between 1995 and 2007. [Leukemia]

ASH Recommends Cross-Disciplinary Engagement to Advance Regenerative Medicine
The American Society of Hematology (ASH) has developed specific recommendations to the scientific community and federal agencies to help propel collaborative research in regenerative medicine in order to make real strides in improving patient care. These recommendations were released in Blood. [American Society of Hematology Press Release]

HemaCare Names Anna Stock Chief Operating Officer and Lisa Bacerra Chief Financial Officer
HemaCare Corporation announced that it has named Anna Stock as Chief Operating Officer and Lisa Bacerra as Chief Financial Officer effective immediately. [MarketWatch]

NeoStem Provides Second Quarter Update
NeoStem, Inc. an international biopharmaceutical company with product and service revenues, global research and development capabilities and operations in three distinct business units, U.S. adult stem cells, China adult stem cells, and China pharmaceuticals is providing results of its second quarter 2010. [NeoStem, Inc. Press Release]

Enhancing Research in Regenerative Medicine
The American Society of Hematology (ASH) convened a working group of experts from the fields of hematopoietic stem cell biology, embryonic stem cells, transplantation biology, and gene therapy at the urging of the Committee on Government Affairs with the goal of developing a "white paper" to inform recommendations to ASH and appropriate parties at the National Institutes of Health (NIH) about the need for additional research in the area of regenerative medicine. [Blood]

International Society for Cellular Therapy (ISCT) Joins Forces with Roche and Genzyme to Launch Cell Therapy Industry Partnership
Many companies in the cell therapy regenerative medicine market including Roche, Genzyme, Athersys, Miltenyi Biotec, Hospira, Lonza and Life Technologies will join ISCT to launch a series of new initiatives that will create greater strategic alignment within the industry and drive late stage clinical development. [International Society for Cellular Therapy Press Release]

7342.007 Addendum - Imported Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) [Center for Biologics Evaluation & Research, United States]

7342.007 - Imported CBER-Regulated Products [Center for Biologics Evaluation & Research, United States]

Currently Cleared CBER 510(k) Clearances [Center for Biologics Evaluation & Research, United States]

July 26-27, 2010: Blood Products Advisory Committee Meeting Presentations [Center for Biologics Evaluation & Research, United States]

Complete List of Licensed Products and Establishments [Center for Biologics Evaluation & Research, United States]

Proposed Collection; Comment Request; NIH NCI Central Institutional Review Board (CIRB) Initiative (NCI) (FR Doc. 2010-20167) [National Institutes of Health, United States]

Center for Scientific Review, Notice of Closed Meetings (FR Doc. 2010-19938) [National Institutes of Health, United States]

Center for Scientific Review, Notice of Closed Meetings (FR Doc. 2010- 20023) [National Institutes of Health, United States]

Center for Scientific Review, Notice of Closed Meetings (FR Doc. 2010- 20044) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20021) [National Institutes of Health, United States]

National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-19939) [National Institutes of Health, United States]

Basic Research on Self-Regulation (R21) (RFA-AG-11-010) [National Institutes of Health, United States]

National Center for Research Resources; Notice of Meeting (FR Doc. 2010-20014) [National Institutes of Health, United States]

EVENTS (Listed by Date)

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences 2nd Annual World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

The European Molecular Biology Organization (EMBO) Meeting 2010
September 4-7, 2010
Barcelona, Spain

International Society for Cellular Therapy (ISCT) - Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

Sickle Cell Disease Association of America (SCDAA) 38th Annual Convention
September 21-24, 2010
Washington D.C., United States

American Society of Hematology (ASH) State-of-the-Art Symposium 2010
September 24-25, 2010
Chicago, United States

Society for the Advancement of Blood Management® (SABM®) 2010 Annual Meeting
September 24-26, 2010
San Juan, Puerto Rico

Stem Cells and Regeneration
October 3-9, 2010
Woods Hole, United States

American Association of Blood Banks (AABB) Annual Meeting 2010
October 9-12, 2010
Baltimore, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Highlights of American Society of Hematology (ASH) Vancouver
January 21-22, 2011
Vancouver, Canada

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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