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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH
Tissue Transglutaminase Contributes to the All-Trans Retinoic Acid Induced Differentiation Syndrome Phenotype in the NB4 Model of Acute Promyelocytic Leukemia
Researchers propose that reduced expression of transglutaminase 2 in differentiating acute promyelocytic leukemia cells may suppress effector functions of neutrophil granulocytes and attenuate the all-trans -retinoic acid-induced inflammatory phenotype of differentiation syndrome. [Blood]
Hedgehog Signaling Maintains Chemoresistance in Myeloid Leukemic Cells
In this study, researchers show that the chemotherapy-resistant phenotype of myeloid leukemia cells correlates with activation of the Hedgehog pathway, whereas in chemosensitive cells, such activation is less pronounced. [Oncogene]
A Functional SUMO-Interacting Motif in the Transactivation Domain of c-Myb Regulates its Myeloid Transforming Ability
Using both a myeloid cell line-based assay and a primary hematopoietic cell assay, researchers addressed the transforming abilities of SUMO binding and conjugation mutants. [Oncogene]
Arsenic Trioxide Induces Apoptosis through JNK and ERK in Human Mesothelioma Cells
These results indicated that As2O3 induces apoptosis of NCI-H2052 cells mainly through JNK1/2 activation, and that ERK1/2 is involved in As2O3-induced apoptosis when JNK1/2 are inactivated. [J Cell Physiol]
Regulation of the PML Tumor Suppressor in Drug-Induced Senescence of Human Normal and Cancer Cells by JAK/STAT-Mediated Signaling
Here, researchers show that genotoxic drugs that induce senescence, such as 5-bromo-2'deoxyuridine, thymidine, distamycin A, aphidicolin, etoposide and camptothecin all evoke expansion of Promyelocytic leukemia protein nuclear compartment and its association with persistent DNA lesions in several human cancer cell lines and normal diploid fibroblasts. [Cell Cycle]
Dasatinib Alters the Metastatic Phenotype of B16-OVA Melanoma In Vivo
Although the mechanisms by which dasatinib alters the metastatic behavior of B16-OVA cells in vivo remain to be determined, researchers hypothesize that dasatinib acts via multiple tumor-extrinsic processes that include immune function and neoangiogenesis. [Cancer Biol Ther]
CLINICAL RESEARCH
Prospective Evaluation of Allogeneic Hematopoietic Stem-Cell Transplantation From Matched Related and Matched Unrelated Donors in Younger Adults With High-Risk Acute Myeloid Leukemia: German-Austrian Trial AMLHD98A
This study assesses the impact of allogeneic hematopoietic stem-cell transplantation from matched related donors and matched unrelated donors on outcome in high-risk patients with acute myeloid leukemia within a prospective multicenter treatment trial. [J Clin Oncol]
In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study
In situ tumor vaccination with a TLR9 agonist induces systemic antilymphoma clinical responses. [J Clin Oncol]
Prognosis of Binet Stage A Chronic Lymphocytic Leukemia Patients: The Strength of Routine Parameters
Researchers propose an easy, fast, cost-effective strategy for a trustworthy prognostication in stage A patients, who currently represent over 80% of the chronic lymphocytic leukemia population, allowing physicians to adapt follow-up individually. [Blood]
Th17 Immune Responses Contribute to the Pathophysiology of Aplastic Anemia
Th17 immune responses contribute to aplastic anemia pathohysiology, especially at the early stage during disease progression. [Blood]
Treatment of Patients with Relapsed/Refractory Multiple Myeloma with Lenalidomide and Dexamethasone With or Without Bortezomib: Prospective Evaluation of the Impact of Cytogenetic Abnormalities and of Previous Therapies
Researchers prospectively studied the impact of several cytogenetic abnormalities in patients with relapsed/refractory myeloma who received lenalidomide and dexamethasone with or without the addition of bortezomib. [Leukemia]
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POLICY NEWS
Court Sides With State in Baby Blood Storage Case
Minnesota did not violate families' privacy rights by collecting and storing children's blood samples, the state Court of Appeals ruled. [Counthouse News Service]
NIH Director Collins Says Cell Ruling Won't Halt Most Ongoing Grants
National Institutes of Health (NIH) Director Francis Collins said that the court injunction blocking federally funded research on human embryonic stem cells will not affect grant payments that have already gone out the door this year. [National Institutes of Health, United States]
NIH Director's Response to Stem Cell Injunction [National Institutes of Health, United States]
Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20861) [National Institutes of Health, United States]
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-21357) [National Institutes of Health, United States]
National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-21282) [National Institutes of Health, United States]
National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-21317) [National Institutes of Health, United States]
National Human Genome Research Institute; Notice of Meetings (FR Doc. 2010-20858) [National Institutes of Health, United States]
National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-21280) [National Institutes of Health, United States]
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EVENTS (Listed by Date)
The European Molecular Biology Organization (EMBO) Meeting 2010
September 4-7, 2010
Barcelona, Spain
International Society for Cellular Therapy (ISCT) - Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy
Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States
Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia
Sickle Cell Disease Association of America (SCDAA) 38th Annual Convention
September 21-24, 2010
Washington D.C., United States
American Society of Hematology (ASH) State-of-the-Art Symposium 2010
September 24-25, 2010
Chicago, United States
Society for the Advancement of Blood Management® (SABM®) 2010 Annual Meeting
September 24-26, 2010
San Juan, Puerto Rico
Stem Cells and Regeneration
October 3-9, 2010
Woods Hole, United States
American Association of Blood Banks (AABB) Annual Meeting 2010
October 9-12, 2010
Baltimore, United States
Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany
52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States
Highlights of American Society of Hematology (ASH) Vancouver
January 21-22, 2011
Vancouver, Canada
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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