CURRENT PUBLICATIONS

Extracellular Redox Modulation by Regulatory T cells
Researchers demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. [Nat Chem Biol]

Activating Receptors Promote NK Cell Expansion for Maintenance, IL-10 Production, and CD8 T Cell Regulation During Viral Infection
Studies demonstrate a previously unappreciated critical role for activating receptors in keeping NK cells present during viral infection to regulate adaptive immune responses. [J Exp Med]

Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions
The intestinal immune system discriminates between tolerance toward the commensal microflora and robust responses to pathogens. Maintenance of this critical balance is attributed to mucosal dendritic cells (DCs) residing in organized lymphoid tissue and dispersed in the subepithelial lamina propria. [Immunity]

A Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-15 Fusokine Induces a Regulatory B Cell Population with Immune Suppressive Properties
Researchers show that ex vivo GIFT15 treatment of mouse splenocytes generates suppressive regulatory cells of B cell ontogeny (hereafter called GIFT15 Breg cells). [Nat Med]

Mast Cells Counteract Regulatory T-cell Suppression Through Interleukin-6 and OX40/OX40L Axis Toward Th17-Cell Differentiation
In vivo analysis of lymph nodes hosting T-cell priming in experimental autoimmune encephalomyelitis revealed activated MCs, Tregs, and Th17 cells displaying tight spatial interactions, further supporting the occurrence of an MC-mediated inhibition of Treg suppression in the establishment of Th17-mediated inflammatory responses. [Blood]

The Same Systemic Autoimmune Disease Provokes Arthritis and Endocarditis via Distinct Mechanisms
Scientists report the discovery of spontaneous endocarditis, in addition to their well-studied autoimmune arthritis, in K/BxN T cell receptor (TCR) transgenic mice. [PNAS]

Insulin Teaches a New Lesson in Tolerance
Study describes how a failure of central tolerance to insulin causes type 1 diabetes in a mouse strain resistant to spontaneous autoimmune diabetes. [EMBO J]

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