CURRENT PUBLICATIONS

How Punctual Ablation of Regulatory T Cells Unleashes an Autoimmune Lesion within the Pancreatic Islets
Treg cells regulate pancreatic autoimmunity in situ through control of a central innate immune system player, NK cells. [Immunity]

Indispensable Role of the Runx1-CbfBeta Transcription Complex for In Vivo-Suppressive Function of FoxP3+ Regulatory T Cells
Results indicate that the Runx1-CbfBeta heterodimer is indispensable for in vivo Treg cell function, in particular, suppressive activity and optimal expression of FoxP3. [Immunity]

Thymic Self-Reactivity Selects Natural Interleukin 17-Producing T Cells that can Regulate Peripheral Inflammation
Interleukin 17 (IL-17)-producing CD4+ helper T cells (TH-17 cells) share a developmental relationship with Foxp3+ regulatory T cells (Treg cells). Here we show that a TH-17 population differentiates in the thymus in a manner influenced by recognition of self antigen and by the cytokines IL-6 and transforming growth factor-beta (TGF-beta). [Nat Immunol]

Effector T Cell Interactions with Meningeal Vascular Structures in Nascent Autoimmune CNS Lesions
Using intravital two-photon imaging in a Lewis rat model of experimental autoimmune encephalomyelitis, here we present in real-time the interactive processes between effector T cells and cerebral structures from their first arrival to manifest autoimmune disease. [Nature]

Tumor-Specific CD8+ T Cells Infiltrating Prostatic Tumors Are Induced to Become Suppressor Cells
Researchers report that tumor-specific CD8+ (TcR-I) T cells suppress the proliferation of naive T cells. This suppression is mediated at least in part by secreted factors, and the suppressive activity can be blocked by antibodies directed against TGF-Beta. [J Immunol]

Helminth Antigens Modulate Immune Responses in Cells from Multiple Sclerosis Patients through TLR2-Dependent Mechanisms
To better understand the link between parasite infections and the course of multiple sclerosis (MS), researchers studied the role of TLRs in helminth product recognition by dendritic cells (DCs) and B cells. [J Immunol]

Expansion of Allospecific Regulatory T Cells after Anergized, Mismatched Bone Marrow Transplantation
Inactivation of alloreactive T cells by inducing tolerance to patient cells (anergization) before transplantation preserves beneficial donor T cell effects while reducing graft-versus-host disease. [Sci Transl Med]

Loss of SOCS3 Expression in T Cells Reveals a Regulatory Role for Interleukin-17 in Atherosclerosis
Results identify novel SOCS3-controlled IL-17 regulatory pathways in atherosclerosis and may have important implications for the understanding of the increased susceptibility to vascular inflammation in patients with dominant-negative STAT3 mutations and defective Th17 cell differentiation. [J Exp Med]

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