CURRENT PUBLICATIONS

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity
Th17 cells elicited a protective inflammation that promotes the activation of tumor-specific CD8+ T cells. [Immunity]

Epigenetic Mechanisms of Regulation of Foxp3 Expression
Different cis-regulatory elements at the Foxp3 locus are subjected to epigenetic modification in different subsets of CD4+ T cells and regulate Foxp3 expression, and how these mechanisms can be exploited to generate efficiently large numbers of suppressive Tregs for therapeutic purposes. [Blood]

Dendritic Cell Function in Allostimulation Is Modulated by C5aR Signaling
Results demonstrate that C5a acts directly on C5aR expressed on DCs resulting in the cell activation and subsequently enhances its capacity for allospecific T cell stimulation. [J Immunol]

Therapy of Experimental Type 1 Diabetes by Isolated Sertoli Cell Xenografts Alone
Curative effects by SC were strictly dependent on efficient tryptophan metabolism in the xenografts, leading to TGF-beta-dependent emergence of autoantigen-specific regulatory T cells and recovery of beta cell function in the diabetic recipients. [J Exp Med]

Human Follicular Lymphoma CD39+-Infiltrating T Cells Contribute to Adenosine-Mediated T Cell Hyporesponsiveness
In this study, researchers identify pericellular adenosine, interacting with T cell-associated G protein-coupled A2A/B adenosine receptors (AR), as contributing to human follicular lymphoma T cell hyporesponsiveness. [J Immunol]

Chronic CD70-Driven Costimulation Impairs IgG Responses by Instructing T Cells to Inhibit Germinal Center B Cell Formation through FasL-Fas Interactions
CD70-driven costimulation enables T cells to terminate B cell responses, thereby compromising durable Ab production. Findings imply that the CD70- and CD27-driven costimulatory axis may be involved in shutdown of B cell responses before clearance of Ag. [J Immunol]

Depletion of Endogenous Tumor-Associated Regulatory T cells Improves the Efficacy of Adoptive Cytotoxic T-cell Immunotherapy in Murine Acute Myeloid Leukemia
To elucidate host factors contributing to the poor response of adoptively transferred tumor-reactive cytotoxic T lymphocytes (CTLs), scientists used a systemic model of murine acute myeloid leukemia (AML). AML progression resulted in a progressive regulatory T-cell (Treg) accumulation in disease sites. [Blood]

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