CURRENT PUBLICATIONS

CD4+FOXP3+ Regulatory T Cells Confer Long-Term Regulation of Factor VIII-Specific Immune Responses in Plasmid-Mediated Gene Therapy-Treated Hemophilia Mice
Antigen-specific Tregs can provide long-lasting protection against immune responses in vivo and limit recall responses induced by a second challenge via infectious tolerance. [Blood]

Lung Interstitial Macrophages Alter Dendritic Cell Functions to Prevent Airway Allergy in Mice
Lung interstitial macrophages (IMs), a cell population with no previously described in vivo function, prevented the induction of a Th2 response in mice challenged with LPS and an experimental harmless airborne antigen. [J Clin Invest]

Superagonistic CD28 Stimulation of Allogeneic T Cells Protects from Acute Graft-Versus-Host Disease
Researchers investigated the effect of immunomodulatory superagonistic anti-CD28 monoclonal antibodies (CD28-SA) on the capacity of allogeneic T cells to mediate both aGVHD and the protective graft-versus-tumor (GVT) response. [Blood]

FoxP3+ Regulatory T Cells Restrain Splenic Extramedullary Myelopoiesis via Suppression of Hemopoietic Cytokine-Producing T Cells
Researchers investigated the mechanism by which FoxP3+ regulatory T cells regulate the extramedullary myelopoiesis. [J Immunol]

Homeostasis of Dendritic Cells in Lymphoid Organs is Controlled by Regulation of their Precursors Via a Feedback Loop
Using a mouse model allowing continuous DC depletion, scientists show that maintenance of DC numbers in spleen is an active process mediated by Flt3-L-dependent regulation of precursor differentiation into DCs, rather than by changes in proliferation of the differentiated DCs. [Blood]

Islet Allograft Rejection Is Independent of Toll-Like Receptor Signaling in Mice
Findings indicate that islet allograft rejection in mice is independent of toll-like receptors 4 (TLR4) and the TLR adaptor molecules MyD88 and Ticam-1, speaking against an essential role for TLR signaling in islet allograft rejection. [Transplantation]

Protein Kinase B/Akt Signals Impair Th17 Differentiation and Support Natural Regulatory T Cell Function and Induced Regulatory T Cell Formation
Data indicate an important role of PKB signals on control of TGF-Beta1-mediated T cell responses and, thereby, on tolerizing and inflammatory immune processes. [J Immunol]

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