CURRENT PUBLICATIONS

A Dominant, Coordinated T Regulatory Cell-IgA Response to the Intestinal Microbiota
Intestinal IgA, but not serum IgA, was found to block mucosal flagellin uptake and systemic T cell activation in mice. [PNAS]

Th22 Cells Represent a Distinct Human T Cell Subset Involved in Epidermal Immunity and Remodeling
The human Th22 subset may represent a separate T cell subset with a distinct identity with respect to gene expression and function, present within the epidermal layer in inflammatory skin diseases. [J Clin Invest]

Apoptotic Dendritic Cells Induce Tolerance in Mice through Suppression of Dendritic Cell Maturation and Induction of Antigen-Specific Regulatory T Cells
In vitro culture of apoptotic Dendritic cells (DCs) with immature DCs, results in their uptake by immature DCs, which subsequently turn into tolerogenic DCs, which then secrete TGF-Beta1 and induce Foxp3+ regulatory T cells (Tregs). [J Immunol]

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis
CD4+CD25+Foxp3+CD39+ Treg cells play an important role in constraining pathogenic Th17 cells and their reduction in multiple sclerosis patients might lead to an inability to control IL-17 mediated autoimmune inflammation. [J Immunol]

Ectopic T-bet Expression Licenses Dendritic Cells for IL-12-Independent Priming of Type 1 T Cells In Vitro
T-bet (TBX21) is a transcription factor required for the optimal development of type 1 immune responses. Researchers investigated whether human dendritic cells genetically engineered to express high levels of T-bet promote superior type 1 T cell responses in vitro. [J Immunol]

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes
Different effector T cell subsets with specificity for myelin Ags can induce CNS autoimmunity and that the pathological heterogeneity in multiple sclerosis lesions might in part be due to multiple distinct myelin-reactive effector T cells. [J Immunol]

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