UAB Researchers Discover Antibody Receptor Identity, Propose Renaming Immune-System Gene
Researchers have uncovered the genetic identity of a cellular receptor for the immune system's first-response antibody, a discovery that sheds new light on infection control and immune disorders. [University of Alabama at Birmingham, Birmingham]

A Clue in the Multiple Sclerosis Mystery
Nature Immunology research showed that if a mouse has Th17 cells, but these cells cannot get into the choroid plexus, MS is blocked. [The Dana Foundation, New York]

CURRENT PUBLICATIONS

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection
During highly T helper 1 (Th1) cell-polarized mucosal immune responses, Treg cell numbers collapsed via multiple pathways, including blockade of Treg cell induction and disruption of endogenous Treg cell homeostasis. [Immunity]

Autologous Mesenchymal Stem Cell Treatment Increased T Regulatory Cells with No Effect on Disease Activity in Two Systemic Lupus Erythematosus Patients
Scientists evaluate the safety and efficacy of bone marrow-derived Mesenchymal stem cells in two human systemic lupus erythematosus patients; the suppressor effect of these cells in-vitro and the change in CD4+CD25+FoxP3+ T regulatory cells in response to treatment. [Lupus]

Structural Basis of Receptor Sharing by Interleukin 17 Cytokines
Interleukin 17 (IL-17)-producing helper T cells (TH-17 cells), together with their effector cytokines, including members of the IL-17 family, are emerging as key mediators of chronic inflammatory and autoimmune disorders. Researchers idenfity the crystal structure of a complex of IL-17 receptor A (IL-17RA) bound to IL-17F in a 1:2 stoichiometry. [Nat Immunol]

Dock8 Mutations Cripple B Cell Immunological Synapses, Germinal Centers and Long-Lived Antibody Production
To identify genes and mechanisms involved in humoral immunity, researchers performed a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. [Nat Immunol]

P-Selectin Glycoprotein Ligand-1 Negatively Regulates T Cell Immune Responses
Results reveal a novel regulatory role for P-selectin glycoprotein ligand-1 (PSGL-1) in T cell adhesion and proliferation and suggest that PSGL-1 negatively regulates T cell immune responses in vivo. [J Immunol]

Coactivation of Syk Kinase and MyD88 Adaptor Protein Pathways by Bacteria Promotes Regulatory Properties of Neutrophils
During a chronic infection, neutrophil depletion promoted inflammation and decreased the mycobacterial burden. Therefore, neutrophils can have a previously unsuspected regulatory role during acute and chronic microbial infections. [Immunity]

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