Connexon Creative - Immune Regulation News 1.10, December 18th, 2009

Immune Regulation News 1.10, December 18, 2009. Click here if you are unable to see images in this e-mail.

In this issue: Science News | Current Publications | Industry News | Policy News | Events

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TOP STORY

Biological Catch-22 Prevents Induction of Antibodies that Block HIV
Scientists seeking to understand how to make an AIDS vaccine have found the cause of a major roadblock. It turns out that the immune system can indeed produce cells with the potential to manufacture powerful HIV-blocking antibodies, but at the same time, the immune system works equally hard to make sure these cells are eliminated before they have a chance to mature. [Center for HIV/AIDS Vaccine Immunology at Duke University Medical Center, Durham]

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SCIENCE NEWS

Immune Cell Activity Linked To Worsening COPD
A new study links chronic obstructive pulmonary disease, or COPD, with increased activity of cells that act as sentinels to activate the body's immune system. [The University of Michigan, Ann Arbor]

Research Breakthrough on Body's Immune System
A critical imbalance of the regulatory cells required to control the immune system has been revealed among people suffering inflammatory bowel disease. [University of Adelaide, Adelaide]

First Immunological Clue To Why Some H1N1 Patients Get Very Ill or Die
An international team of Canadian and Spanish scientists have found the first potential immunological clue of why some people develop severe pneumonia when infected by the pandemic H1N1 virus. [Hospital Clinico Universitario de Valladolid, Valladolid]

CURRENT PUBLICATIONS

Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome
Although Foxp3 expression marks the commitment of progenitors to regulatory T (Treg) cell lineage, how Treg cells are generated during lymphocyte development remains enigmatic. This study reports that the c-Rel transcription factor controls the development of Treg cells by promoting the formation of a Foxp3-specific enhanceosome. [Immunity]

Autoreactivity in an HIV-1 Broadly Reactive Neutralizing Antibody Variable Region Heavy Chain Induces Immunologic Tolerance
To test directly whether rare neutralizing HIV-1 antibodies can activate immunologic tolerance mechanisms, researchers generated a knock-in mouse in which the Ig heavy chain variable region rearrangement (VHDJH) from the polyreactive and broadly neutralizing human monoclonal antibody 2F5 was targeted into the mouse Igh locus. [PNAS]

Foxp3+ Regulatory T Cells Essentially Contribute to Peripheral CD8+ T Cell Tolerance Induced by Steady-State Dendritic Cells
Antigen presentation by steady-state dendritic cells failed to induce peripheral tolerance in the absence of Foxp3+ regulatory T cells but induced protective CD8+ T cell-mediated immunity instead. [PNAS]

Homeostatic Imbalance of Regulatory and Effector T Cells Due to IL-2 Deprivation Amplifies Murine Lupus
In the F1 mouse model of lupus, CD4+Foxp3+ regulatory T (Treg) cell failed to maintain a competitive pool size in the peripheral lymphoid organs resulting in a progressive homeostatic imbalance of CD4+Foxp3+ Treg and CD4+Foxp3- conventional T cells. [PNAS]

In vivo Delivery of a MicroRNA-Regulated Transgene Induces Antigen-Specific Regulatory T Cells and Promotes Immunologic Tolerance
In the context of lentiviral vector-mediated gene transfer, detargeting antigen expression from professional antigen-presenting cells (APCs), coupled with expression in hepatocytes, can induce antigen-specific immunologic tolerance. [Blood]

Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease
Inflammatory bowel disease is associated with a reduced ratio of regulatory T (Treg) cells to Th17 cells in peripheral blood and is characterized by a proinflammatory cytokine microenvironment, which supports the continued generation of Th17 cells. [J Clin Immunol]

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INDUSTRY NEWS

Roche, Ipsen Diabetes Drug Meets Goals in Studies
A weekly diabetes drug from Roche met its goals in two late-stage clinical trials, part of a series of studies required for approval, the Swiss drugmaker said on Thursday.

Biogen Should Raise Facet Bid to $22, Analyst Says
Biogen Idec Inc. needs to raise its unsolicited takeover bid for partner Facet Biotech Corp. to at least $22 a share to succeed, a Merriman Curhan Ford & Co. analyst said.

POLICY NEWS

La Jolla Institute for Allergy & Immunology Awarded $18.8Million NIH Grant for Infectious Diseases Study
The Institute received four project awards totaling $18.8 million from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, to fund the study. [La Jolla Institute for Allergy and Immunology, La Jolla]

EVENTS

9th International Conference on New Trends in Immunosuppression and Immunotherapy
February 4-6, 2010
Geneva, Switzerland

13th International Conference on Lymphocyte Activation and Immune Regulation: Inflammasome and Inflammation
February 5-7, 2010
Newport Beach, United States

Keystone Symposia: Tolerance and Autoimmunity
February 21-26, 2010
Taos, United States

World Immune Regulation Meeting - IV
March 29-April 1, 2010
Davos, Switzerland

IMMUNOLOGY 2010
May 7-11, 2010
Baltimore, United States

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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