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Immune Regulation News 2.17, May 14, 2010. Refer to the archive if you are unable to see images in this email.

In this issue: Science News | Current Publications | Industry News | Policy News | Events

TOP STORY

Foxo Proteins Cooperatively Control the Differentiation of Foxp3+ Regulatory T Cells
Here researchers show that mice with T cell-specific deletion of both the Foxo1 and Foxo3 transcription factors developed a fatal multifocal inflammatory disorder due in part to regulatory T cell defects. [Nat Immunol]

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SCIENCE NEWS

Cancer: Trapping the Escape Artist
Researchers outline how the six anti-apoptotic proteins in the Bcl-2 family are expressed differently in different cancers. [Press release from the Sanford-Burnham Medical Research Institute discussing online prepublication in Cell Death and Disease]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Transforming Growth Factor-Beta Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development
Here researchers showed that transforming growth factor-beta signaling protected naturally occurring regulatory T cells and antigen-stimulated conventional T cells from apoptosis. [Immunity]

Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage
Researchers identified epigenetic modifications across the clustered Il17a and Il17f and the Ifng loci before and after differential IL-12 or TGF-beta cytokine signaling, which induce divergent fates of Th17 cell precursors. [Immunity]

Antibodies Specific for a Segment of Human Membrane IgE Deplete IgE-Producing B Cells in Humanized Mice
Here, researchers have developed a strategy to disrupt IgE production by generating monoclonal antibodies that target a segment of membrane IgE on human IgE-switched B cells that is not present in serum IgE. [J Clin Invest]

The Route of Priming Influences the Ability of Respiratory Virus-Specific Memory CD8+ T Cells to be Activated by Residual Antigen
Researchers used mouse models of influenza and parainfluenza virus infection to show that intranasally (i.n.) primed memory CD8+ T cells possess a unique ability to be reactivated by residual antigen in the mediastinal lymph nodes compared with intraperitoneally primed CD8+ T cells, resulting in the preferential recruitment of i.n.-primed memory CD8+ T cells to the lung airways. [J Exp Med]

Complement Drives Th17 Cell Differentiation and Triggers Autoimmune Arthritis
Collectively, the data suggest that complement activation by exogenous or endogenous stimulation can initiate Th17 cell differentiation and expansion in certain autoimmune diseases and presumably in microbial infections. [J Exp Med]

Systemic Autoimmunity and Defective Fas Ligand Secretion in the Absence of the Wiskott-Aldrich Syndrome Protein
Researchers find that WAS protein-deficient mice produce autoantibodies and develop proliferative glomerulonephritis with immune complex deposition as they age. [Blood]

Differentiation of Type 1 T Regulatory Cells by Tolerogenic DC-10 Requires the IL-10-Dependent ILT4/HLA-G Pathway
Researchers identified and characterized a subset of IL-10-producing human DC, termed DC-10, which are present in vivo and can be induced in vitro in the presence of IL-10. [Blood]

Induction of Regulatory T Cells Decreases Adipose Inflammation and Alleviates Insulin Resistance in Ob/Ob Mice
Researchers induced TGF-beta-dependent CD4+ latency-associated peptide-positive regulatory T cells by oral administration of anti-CD3 antibody plus beta-glucosylceramide. [Proc Natl Acad Sci U S A]

The Death Effector Domain Protein PEA-15 Negatively Regulates T Cell Receptor Signaling
To determine the function of PEA-15 in vivo, researchers used C57BL/6 mice in which the PEA-15 coding region was deleted. [FASEB J]

Human Tumor Antigen-Specific Helper and Regulatory T Cells Share Common Epitope Specificity but Exhibit Distinct T Cell Repertoire
In this study, researchers show that two immunodominant epitopes derived from the tumor antigens NY-ESO-1 and TRAG-3 stimulate both CD4+ T helper cells and regulatory T cells. [J Immunol]

INDUSTRY NEWS

Abstract Published on Initial Results From XOMA 052 Clinical Trial in Behcet's Disease
XOMA Ltd. announced the publication of an abstract titled, "Safe, Rapid-onset and Sustained Biological Activity of IL-1 beta Regulating Antibody XOMA 052 in Resistant Uveitis of Behcet's Disease: Preliminary Results of a Pilot Trial." [Xoma Ltd. Press Release]

Idera Pharmaceuticals Reports First Quarter 2010 Financial Results and Provides Pipeline Update
Idera Pharmaceuticals, Inc., a biotechnology company engaged in the discovery and development of DNA- and RNA-based drug candidates targeted to Toll-like Receptors, reported financial results for the first quarter ended March 31, 2010. [Idera Pharmaceuticals, Inc., Press Release]

SQI Diagnostics Presents Key Clinical and Product Development Specificity and Sensitivity Data at European Autoimmune Conference
SQI Diagnostics Inc. announced data from oral and poster presentations that highlights the Company's leadership position in the autoimmune diagnostics space. [SQI Diagnostics Inc. Press Release]

POLICY NEWS

NIH Starts to Flesh out Drug Development Program
Lawmakers began discussing the details of a newly created drug development program at the National Institutes of Health (NIH). NIH Director Francis Collins told a Senate panel that he's eager to get started-once the program has a budget. [National Institutes of Health, United States]

NSF to Ask Every Grant Applicant for Data Management Plan
Scientists seeking funding from the National Science Foundation (NSF) will soon need to spell out how they plan to manage the data they hope to collect. It's part of a broader move by NSF and other federal agencies to emphasize the importance of community access to data. [National Science Foundation, United States]

Notice of Funding Opportunity for a Cell Characterization Core for the National Heart, Lung and Blood Institute Progenitor Cell Biology Consortium (NOT-HL-10-109) [National Institutes of Health, United States]

Notice of Intent to Publish Request for Applications for the Blood and Marrow Transplant Clinical Trials Network Data Coordinating Center (U10) (NOT-HL-10-108) [National Institutes of Health, United States]

Enhancing Peer Review: Expectation for Service on NIH Peer Review and Advisory Groups (NOT-OD-10-089) [National Institutes of Health, United States]

Request for Information: Scientific and Regulatory Issues to be Explored at an Upcoming Pluripotent Stem Cell Workshop Involving NIH and FDA (NOT-NS-10-016) [National Institutes of Health, United States]

Drug Safety and Risk Management Advisory Committee; Notice of Meeting (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]

Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental Study of Patient Information Prototypes (Docket No. FDA-2010-N-0184) [Food and Drug Administration, United States]

EVENTS

29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI)
June 5-9, 2010
London, United Kingdom

Keystone Symposia: Innate Immunity - Mechanisms Linking with Adaptive Immunity (D3)
June 7-12, 2010
Dublin, Ireland

Federation of Clinical Immunology Societies (FOCIS) 2010
June 24-27, 2010
Boston, United States

The 2nd International Conference on Regulatory T Cells and TH17 Cells and Clinical Application in Human Diseases
July 17-20, 2010
Shanghai, China

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

Select BioSciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza - Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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