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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
N-Linked Glycosylation Selectively Regulates Autonomous Precursor BCR Function
The results suggest an unexpected mode of pre-B cell antigen receptors (BCR) function, in which binding of the surrogate light chain to N46 mediates autonomous crosslinking and, concomitantly, receptor formation. [Nat Immunol]
Granulysin Activates Antigen-Presenting Cells Through TLR4 and Acts as an Immune Alarmin
Researchers report that both 9- and 15-kDa forms of recombinant GNLY induced in vitro chemotaxis and activation of both human and mouse dendritic cells, recruited inflammatory leucocytes including antigen-presenting cells in mice, and promoted antigen-specific immune responses upon co-administration with an antigen. [Blood]
Pannexin-1 Hemichannel-Mediated ATP Release Together with P2X1 and P2X4 Receptors Regulate T Cell Activation at the Immune Synapse
Here, researchers tested the roles of pannexin-1 hemichannels, which have been implicated in ATP release, and of various P2X receptors, which serve as ATP-gated Ca2+ channels, in events that control T cell activation. [Blood]
Immune Activation Induces Immortalization of HTLV-1 LTR-Tax Transgenic CD4+ T Cells
Researchers suggest that immune activation of infected CD4+ T cells plays an important role in the induction of Tax expression, T cell proliferation, and pathogenesis of ATL in HTLV-1-infected individuals. [Blood]
Arabinogalactan Isolated from Cowshed Dust Extract Protects Mice from Allergic Airway Inflammation and Sensitization
The objective of this study was to identify immunomodulatory molecules in extracts of dust from an allergy protective farming environment. [J Allergy Clin Immunol]
An Allelic Variant of Crry in the Murine Sle1c Lupus Susceptibility Interval Is Not Impaired in Its Ability to Regulate Complement Activation
These data fail to provide evidence for a functional effect of the structural alterations in Sle1c Crry and suggest that the role of Cr2 in the Sle1c autoimmune phenotypes can be isolated in recombinant congenic mice containing both genes. [J Immunol]
Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12(low)IL-10(high) Regulatory Phenotype in Macrophages
In this study, researchers investigated whether neutrophil efferocytosis induces a stable macrophage phenotype that could be recalled by late restimulation with LPS. [J Immunol]
An Atopic Dermatitis-Like Skin Disease with Hyper-IgE-Emia Develops in Mice Carrying a Spontaneous Recessive Point Mutation in the Traf3ip2 (Act1/CIKS) Gene
This study demonstrates that the TRAF3IP2 protein plays an important role in atopic dermatitis (AD) and suggests the protein as a therapeutic target to treat AD. [J Immunol]
Endogenous MMP2 and MMP9 Regulate Activation of CD4+ and CD8+ T Cells
Matrix metalloproteinases (MMP), particularly MMP9, may function intracellularly to regulate T cell activation. T cell targeted MMP inhibition may provide a novel approach of immune regulation in the treatment of T cell-mediated diseases. [Am J Respir Cell Mol Biol]
Stromal Cells' B7-1 is a Key Stimulatory Molecule for Interleukin-10 Production by HOZOT, a Multifunctional Regulatory T Cell Line
Distinct from ICOSL or PD-L1 expressed on dendritic cells, this study showed that B7-1 on stromal cells is a key molecule regulating IL-10 production by multifunctional regulatory T cells, HOZOT. [Immunol Cell Biol]
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INDUSTRY NEWS
Abbott Reports Strong Second Quarter Results; Confirms Double-Digit Ongoing Earnings Growth Outlook for 2010
Abbott announced financial results for the second quarter ended June 30, 2010. [Abbott Laboratories Inc. Press Release]
FDA Accepts AFREZZA Complete Response Resubmission and Sets Target Action Date
MannKind Corporation announced that it has submitted, and the U.S. Food and Drug Administration has accepted, MannKind's resubmission of its New Drug Application for AFREZZA(TM) and classified it as a Class II resubmission. [MannKind Corporation Press Release]
$1.85 Million Grant Explores New Treatment for Rheumatoid Arthritis
Dr. Laura Mandik-Nayak, Assistant Professor at the Lankenau Institute for Medical Research, received a five-year, $1,856,250 National Institutes of Health (NIH) grant for a research project entitled: IDO in inflammatory pathogenesis and treatment of rheumatoid arthritis. [Lankenau Institute for Medical Research Press Release]
MorphoSys to Host Q2 2010 Conference Call on July 28, 2010
MorphoSys AG will publish its first six months' 2010 results on July 28, 2010 at 7:00 a.m. CET. [The Wall Street Journal]
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POLICY NEWS
Ireland Keeps Light Shining on Science with New Spending
In a surprise move, the Irish government (which is tottering on the brink of bankruptcy) announced that it would inject 359 million Euros into research. [Programme for Reseach in Third-Level Institutions, Ireland]
Russian Researchers Call for Better Coordination of Science
More than 2200 researchers sent an open letter to Russian President Dmitry Medvedev last week asking the government to set Russian science in order and to consult with the scientific community when making major science-policy decisions. [Russia]
"Game Over" for British Science?
The Royal Society and the British Academy strongly warned the British government that looming cuts to science funding could be "irreversibly catastrophic for the future of U.K. science and economic growth" if they go too far. [The Royal Society and the British Academy, United Kingdom]
House Panel Approves 3.2% Raise for NIH in 2011
A House of Representatives spending panel yesterday approved a $1 billion increase, to $32 billion, in the 2011 budget for the National Institutes of Health (NIH). [National Institutes of Health, United States]
NIH Expands National Network for Transforming Clinical and Translational Research
Nine health research centers have received funds to develop ways to reduce the time it takes for clinical research to become treatments for patients. The funds were awarded as part of the Clinical and Translational Science Awards program which is led by the National Center for Research Resources. [National Institutes of Health, United States]
Pre-Application Meeting for Request for Applications (RFA-CA-10-016) for the Clinical Proteomic Technologies for Cancer Initiative (CPTC): Proteome Characterization Centers (NOT-CA-10-031) [National Institutes of Health, United States]
Notice of Intent to Publish a Request for Applications for Tumor Microenvironment Network (TMEN) (NOT-CA-10-032) [National Institutes of Health, United States]
Notice of Expiration of Biomedical Technology Research Resource (PAR-08-259) and Reissuance of Biomedical Technology Research Center (P41)(PAR-10-225) (NOT-RR-10-011) [National Institutes of Health, United States]
2011 NIH Directors New Innovator Award Program (DP2) (RFA-RM-10-009) [National Institutes of Health, United States]
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EVENTS (Listed by Date)
CHI's 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS)
August 17-19, 2010
Cambridge, United States
14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan
Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland
Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland
Select Biosciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland
Immunology & Microbiology, Genetics & Genomics, Development, Other
September 18-22, 2010
Barcelona, Spain
Cell Symposia: Inflammation and Disease
September 26-28, 2010
Lisbon, Portugal
11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology - DC2010: Forum on Vaccine Science
September 26-30, 2010
Lugano, Switzerland
5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece
Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States
Cell Symposia: Influenza - Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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