CURRENT PUBLICATIONS
LABORATORY RESEARCH
Genes that Mediate Breast Cancer Metastasis to the Brain
Here researchers show that breast cancer metastasis to the brain involves mediators of extravasation through non-fenestrated capillaries, complemented by specific enhancers of blood-brain barrier crossing and brain colonization. [Nature]
TrkA Overexpression Enhances Growth and Metastasis of Breast Cancer Cells
French scientists provide the first direct evidence that TrkA overexpression enhances the tumorigenic properties of breast cancer cells and point to TrkA as a potential target in breast cancer therapy. [Oncogene]
ER{alpha} as Ligand-Independent Activator of CDH-1 Regulates Determination and Maintenance of Epithelial Morphology in Breast Cancer Cells
ER{alpha} is bound to the E-cadherin promoter in both the presence and the complete absence of estrogen, suggesting an unexpected role for unliganded ER{alpha} in E-cadherin transcription. [PNAS]
Hsp90 Inhibitor PU-H71, a Multimodal Inhibitor of Malignancy, Induces Complete Responses in Triple-Negative Breast Cancer Models
Triple-negative breast cancer (TNBC) xenograft tumors are demonstrated to be sensitive to the heat shock protein 90 (Hsp90) inhibitor PU-H71. [PNAS]
Gene Expression in Murine Mammary Epithelial Stem Cell-Like Cells Shows Similarities to Human Breast Cancer Gene Expression
The transcriptional characterization of these mammary stem-like cells and their differentiation-induced gene expression patterns is here made widely accessible and provides a basis for research on mammary stem-like cells. [Breast Cancer Res]
MicroRNA Signatures Predict Estrogen Receptor, Progesterone Receptor and HER2/neu Receptor Status in Breast Cancer
This study demonstrates that artificial neural networks (ANN) analysis reliably identifies biologically relevant miRNAs associated with specific breast cancer phenotypes. The association of specific miRNAs with ER, PR and HER2/neu status indicates a role for these miRNAs in disease classification of breast cancer.
[Breast Cancer Res]
CLINICAL RESEARCH
Topoisomerase II Alpha and Responsiveness of Breast Cancer to Adjuvant Chemotherapy
TOP2A gene alterations are associated with an increase in responsiveness to anthracycline-containing chemotherapy regimens relative to non-anthracycline regimens that is similar to that seen in patients with HER2 amplification. [J Natl Cancer Inst]
Use of Chemotherapy Plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2
Trastuzumab increases the clinical benefit of first-line chemotherapy in metastatic breast cancer that overexpresses HER2. [N Engl J Med]
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