CURRENT PUBLICATIONS
LABORATORY RESEARCH
Regulation of Mammary Gland Branching Morphogenesis by EphA2 Receptor Tyrosine Kinase
Using EphA2-deficient animals, researchers demonstrate for the first time that EphA2 receptor function is required for mammary epithelial growth and branching morphogenesis. [Mol Cell Biol]
WNT Signaling Enhances Breast Cancer Cell Motility and Blockade of the WNT Pathway by sFRP1 Suppresses MDA-MB-231 Xenograft Growth
Results show that the WNT pathway influences multiple biological properties of MDA-MB-231 breast cancer cells. WNT stimulates tumor cell motility; conversely sFRP1 mediated WNT pathway blockade reduces motility. [Breast Cancer Res]
Role of the Protein Tyrosine Kinase Syk in Regulating Cell-Cell Adhesion and Motility in Breast Cancer Cells
The ability of Syk to participate in integrin-mediated protein tyrosine phosphorylation correlates well with its ability to inhibit cell motility. [Mol Cancer Res]
Extracellular Signal-Regulated Kinases 1 and 2 and TRPC1 Channels are Required for Calcium-Sensing Receptor-Stimulated MCF-7 Breast Cancer Cell Proliferation
Research investigated CaR intracellular signaling pathways and examined the role of TRPC1 in CaR-induced cell proliferation, through the extracellular signal-regulated Kinases 1 & 2 (ERK1/2) pathways. [Cell Physiol Biochem]
CtIP-BRCA1 Modulates the Choice of DNA Double-Strand-Break Repair Pathway throughout the Cell Cycle (Letter)
Data support a model in which phosphorylation of serine 327 of CtIP as cells enter S phase and the recruitment of BRCA1 functions as a molecular switch to shift the balance of DSB repair from error-prone DNA end-joining to error-free homologous recombination. [Nature]
The Estrogen Receptor-alpha Pathway Induces Oncogenic Wip1 Phosphatase Gene Expression
Results indicate that Wip1 up-regulation is important in the pathogenesis of p53+ and ER+ breast cancer through the inactivation of p53 by dephosphorylation and the amplification of subsequent estrogenic effects through the E2-ER-alpha-Wip1 pathway. [Mol Cancer Res]
CLINICAL RESEARCH
Elevated Biomarkers of Inflammation are Associated with Reduced Survival among Breast Cancer Patients
Circulating SAA and CRP may be important prognostic markers for long-term survival in breast cancer patients, independent of race, tumor stage, and body mass index. [J Clin Oncol]
Epidemiology of Breast Cancer Subtypes in Two Prospective Cohort Studies of Breast Cancer Survivors
Important modifiable lifestyle factors that may be related to the development of a specific tumor subtype, but not all subtypes, include obesity, breastfeeding and alcohol consumption. [Breast Cancer Res]
A Constant Risk of Familial Breast Cancer? A Population-Based Family Study
Incidence of familial breast cancer in first degree relatives might increase to a high constant level by a predetermined age that is specific to each family. [Breast Cancer Res]
|
