CURRENT PUBLICATIONS
LABORATORY RESEARCH
Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/Beta-Catenin Signaling
Knockdown of PTEN in normal human mammary epithelial cells enriches for the stem/progenitor cell compartment, generating atypical hyperplastic lesions in humanized NOD/SCID mice. [PLoS Biol]
Development of Mammary Tumors by Conditional Expression of GLI1
Transgenic expression of the Hh effector protein GLI1 under the regulation of the mouse mammary tumor virus promoter, expressed in the mouse mammary gland, is associated with the appearance of hyperplastic lesions, defective terminal end buds, and tumor development. [Cancer Res]
Ptch1 is Required Locally for Mammary Gland Morphogenesis and Systemically for Ductal Elongation
Ptch1 functions in the mammary epithelium and stroma to regulate ductal morphogenesis, and in the pituitary to regulate ductal elongation and ovarian hormone responsiveness. [Development]
AGTR1 Overexpression Defines a Subset of Breast Cancer and Confers Sensitivity to Losartan, an AGTR1 antagonist
Results indicate that marked AGTR1 overexpression defines a subpopulation of ER-positive, ERBB2-negative breast cancer that may benefit from targeted therapy with AGTR1 antagonists, such as losartan [PNAS]
Expression of the K303R Estrogen Receptor- Breast Cancer Mutation Induces Resistance to an Aromatase Inhibitor via Addiction to the PI3K/Akt Kinase Pathway
Findings suggest that the K303R ER mutation might be a new predictive marker of response to AIs in mutation-positive breast tumors, and that targeting the PI3K/Akt pathway may be a useful strategy for treating patients with tumors resistant to hormone therapy. [Cancer Res]
Activation of Src by Protein Tyrosine Phosphatase 1B is Required for ErbB2 Transformation of Human Breast Epithelial Cells
Activation of ErbB2, but not ErbB1, increases PTP1B expression, and increased expression of PTP1B activates Src and induces a Src-dependent transformed phenotype. [Cancer Res]
Src Stimulates Fibroblast Growth Factor Receptor-2 Shedding by an ADAM15 Splice Variant Linked to Breast Cancer
ADAM15B has enhanced catalytic activity in cell-based assays compared with ADAM15A, which lacks a Src-binding site, using shedding of fibroblast growth factor receptor 2iiib variant as an assay for catalytic activity. [Cancer Res]
Toward a Stem Cell Gene Therapy for Breast Cancer
Inducible, intratumoral expression of relaxin (Rlx) either by transplanting tumor cells that contained the Rlx gene or by transplantation of mouse HSCs transduced with an Rlx-expressing lentivirus vector delays tumor growth in a mouse model of breast cancer. [Blood]
CLINICAL RESEARCH
Phase II Randomized Study of Neoadjuvant Everolimus Plus Letrozole Compared with Placebo Plus Letrozole in Patients with Estrogen Receptor-Positive Breast Cancer
Everolimus significantly increased letrozole efficacy in neoadjuvant therapy of patients with ER-positive breast cancer. [J Clin Oncol]
Lapatinib Monotherapy in Patients with HER2-Overexpressing Relapsed or Refractory Inflammatory Breast Cancer: Final Results and Survival of the Expanded HER2+ Cohort in EGF103009, a Phase II Study
Lapatinib monotherapy is a potentially effective treatment for relapsed or refractory HER2+ inflammatory breast cancer. [Lancet Oncol]
Radiotherapy and Adjuvant Trastuzumab in Operable Breast Cancer: Tolerability and Adverse Event Data From the NCCTG Phase III Trial N9831
Concurrent adjuvant RT and H for early-stage BC was not associated with increased acute AEs. Further follow-up is required to assess late AEs. [J Clin Oncol]
|
