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CURRENT PUBLICATIONS
LABORATORY RESEARCH
A Naturally Occurring HER2 Carboxy-Terminal Fragment Promotes Mammary Tumor Growth and Metastasis
Results demonstrate that 611-CTF is a potent oncogene capable of promoting mammary tumor progression and metastasis. [Mol Cell Biol]
Myosin-Interacting Guanine Exchange Factor (MyoGEF) Regulates the Invasion Activity of MDA-MB-231 Breast Cancer Cells through Activation of RhoA and RhoC
MyoGEF cooperates with NMIIA to regulate the polarity and invasion activity of breast cancer cells through activation of RhoA and RhoC. [Oncogene]
Rac1 Contributes to Trastuzumab Resistance of Breast Cancer Cells: Rac1 as a Potential Therapeutic Target for the Treatment of Trastuzumab-Resistant Breast Cancer
When parental SKBR3 cells become resistant to trastuzumab, Rac1 activity is increased, leading to altered cell morphology, which is accompanied by significant cytoskeleton disorganization. [Mol Cancer Ther]
Endocrine Dysfunction in p27Kip1 Deficient Mice and Susceptibility to Wnt-1 Driven Breast Cancer
Study shows that while not a significant inhibitor of Wnt-1-driven breast cancer, p27 inhibits gastric tumors, whose latency is modulated by sex steroids. [Carcinogenesis]
Functional Polymorphisms, Altered Gene Expression and Genetic Association Link NRH: Quinone Oxidoreductase 2 to Breast Cancer with Wild-Type p53
Data presented strongly suggest that NQO2 is a susceptibility gene for breast carcinogenesis. [Hum Mol Genet]
Mixed Tocopherols Prevent Mammary Tumorigenesis by Inhibiting Estrogen Action and Activating PPAR-gamma
Mixed tocopherols increased the expression of p21, p27, caspase-3, and peroxisome proliferator activated receptor-gamma, and inhibited AKT and estrogen signaling in mammary tumors. [Clin Cancer Res]
Hedgehog Signaling in Breast Cancer
Inhibition of Hh signaling in breast tumors may interfere with the maintenance of a putative cancer stem cell compartment and the abnormal stimulation of tumor stroma. [Carcinogenesis]
CLINICAL RESEARCH
Comparison of Models to Predict Nonsentinel Lymph Node Status in Breast Cancer Patients with Metastatic Sentinel Lymph Nodes: A Prospective Multicenter Study
Study suggests that all models do not perform equally, especially for the subgroup of patients with only micrometastasis or ITC in the SN. [J Clin Oncol]
Feasibility Trial of Partial Breast Irradiation with Concurrent Dose-Dense Doxorubicin and Cyclophosphamide in Early-Stage Breast Cancer
PBI with concurrent ddAC is feasible, and local/systemic toxicity is acceptable. Larger studies are warranted to assess long-term locoregional control and late toxicities. [J Clin Oncol]
Ki67 Expression and Docetaxel Efficacy in Patients with Estrogen Receptor-Positive Breast Cancer
Ki67 expression identifies a subset of patients with ER-positive breast cancer who could be sensitive to docetaxel treatment in the adjuvant setting. [J Clin Oncol]
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