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SCIENCE NEWS
New! Mammary Epithelial Cell Colony Interactive Tutorial
Explore interactive bi-potent colonies and highlight luminal and basal structures in 3D morphogenesis structures.
Try tutorial now
Targeting MMPs to Halt Advanced Metastatic Breast Cancer
A study reveals how two specific matrix metalloproteinase (MMP) proteins contribute to bone metastasis in advanced breast cancer - lending important new insight into the design of clinically useful small molecule inhibitors.[Princeton University, Princeton]
Stem Cell Transplants Effective for Breast Cancer Survivors with Secondary Leukemia
Stem cell transplantation is an effective treatment option for breast cancer survivors who develop acute leukemia or myelodysplasia following adjuvant chemotherapy. [Susan G. Komen Breast Cancer Foundation, Dallas]
Breast Cancer Drug Shows Promise Against Serious Infections
An FDA-approved drug, Tamoxifen used for preventing recurrence of breast cancer shows promise in fighting life-threatening fungal infections common in immune-compromised patients [University of Rochester, Rochester]
Rhode Island Hospital First in Country to Enroll Patient in New National Study for Treating Recurrent Chest Wall Breast Cancer
Rhode Island hospital will participate in a new clinical trial called the DIGNITY study that investigates the effectiveness of a chemotherapeutic agent, ThermoDox, used in conjunction with mild hyperthermia for treating recurrent chest wall breast cancer.
[Rhode Island Hospital, Providence]
US Oncology Research Network Participates in Phase III Follow-up Study To BiPar's Investigational Cancer Drug BSI-201
US Oncology Research will participate in the BiPar Sciences' Phase III, Multi-center, Open-Label, Randomized Trial of Gemcitabine/Carboplatin, with or without BSI-201, in patients with Estrogen Receptor , Progesterone Receptor, and HER2-negative metastatic breast cancer. [US Oncology Research Network, Woodlands]
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CURRENT PUBLICATIONS
LABORATORY RESEARCH
ADAMTS1 and MMP1 Proteolytically Engage EGF-like Ligands in an Osteolytic Signaling Cascade For Bone Metastasis
Study established MMP1 and ADAMTS1 in tumor cells, as well as EGFR signaling in osteoblasts, as promising therapeutic targets for inhibiting bone metastasis of breast cancer. [Genes Dev]
In Vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models
Single-agent MEK inhibition is a promising therapeutic modality for basal-like breast cancers with intact PTEN, and also provide a basis for rational combination of MEK and PI3K inhibitors in basal-like cancers with both intact and deleted PTEN. [Clin Cancer Res]
Beta-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid-Mediated Migration and Invasion of Human Breast Tumor Cells
Research demonstrated a novel role for Beta-arrestin/Ral signaling in mediating LPA-induced breast cancer cell migration and invasion, two important processes in metastasis. [Mol Cancer Res]
Regulation of Transgenes in Three-Dimensional Cultures of Primary Mouse Mammary Cells Demonstrates Oncogene Dependence and Identifies Cells That Survive Deinduction
When MYC and KrasG12D are induced, the 3D acini structure enlarge and form solid, depolarized spheres. Upon deinduction of MYC and KrasG12D the 3D structures regress, leaving a repolarized monolayer of viable cells.[Genes Dev]
Insulin-Like Growth Factor Type 1 Receptor and Insulin Receptor Isoform Expression and Signaling in Mammary Epithelial Cells
IGF type 1 receptor is more active in signaling than insulin receptor and is the predominant mediator of IGF actions in virgin mammary epithelial cells. [Endocrinology]
Presence of HER4 Associates With Increased Sensitivity To Herceptin in Patients With Metastatic Breast Cancer
Although HER4 is known to potentially exert a tumor cell killing activity and in turn have a favorable impact in breast cancer patients, this study demonstrated for the first time that HER4 expression prolongs overall survival in Herceptin treated patients. [Breast Cancer Res]
Met Induces Mammary Tumors With Diverse Histologies and is Associated With Poor Outcome and Human Basal Breast Cancer
This study identified basal breast cancers and, additionally, poor-outcome breast cancers, as those that may benefit from anti-MET receptor therapies. [PNAS]
CLINICAL RESEARCH
Phase I Study of Apoptosis Gene Modulation With Oblimersen Within Preoperative Chemotherapy in Patients With Primary Breast Cancer
Scientists demonstrated the feasibility of processing clinical samples and obtaining good quality RNA from tumor biopsies and indicated the potential of oblimersen to lower Bcl-2 mRNA in breast cancer. [Ann Oncol]
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Events
Next Generation Comprehensive Breast Centers of Excellence
September 29-October 2, 2009
Baltimore, MD, United States
2009 National Cancer Research Institute Conference
October 4-7, 2009
Birmingham, United Kingdom
Global Breast Cancer Conference
October 8-10, 2009
Seoul, South Korea
Jointly Sponsored 2009 Breast Cancer Symposium
October 8-10, 2009
San Francisco, CA, United States
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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