TOP STORIES

Breakthrough Breast Cancer Scientists Develop New Method to Predict Patient Response to Herceptin
Scientists based in Edinburgh are the first to use computer modeling to answer clinical questions and potentially refine the treatment of women with breast cancer. [Breakthrough Breast Cancer, Edinburgh]

CURRENT PUBLICATIONS

LABORATORY RESEARCH

Laminin-1 Induces E-Cadherin Expression in 3-Dimensional Cultured Breast Cancer Cells by Inhibiting DNA Methyltransferase 1 and Reversing Promoter Methylation Status
Using a 3-dimensional model, this study presented evidence that laminin-1 is capable of inducing epigenetic change by inhibiting expression of DNMT1 and preventing methylation of the E-cadherin promoter, resulting in E-cadherin expression and the formation of cell-cell bonds in malignant carcinoma.  [FASEB]

The Role of miR-206 in The Epidermal Growth Factor (EGF) Induced Repression of Estrogen Receptor-alpha (ER-alpha) Signaling and a Luminal Phenotype in MCF-7 Breast Cancer Cells
MiR-206 contributes to EGFR-mediated abrogation of estrogenic responses in MCF-7 cells, contributes to a Luminal-A- to Basal-like phenotypic switch, and may be a measure of EGFR response within Basal-like breast tumors. [Molecular Endcrinology]

Targeting Janus Kinase 2 in Her2/neu-Expressing Mammary Cancer: Implications for Cancer Prevention and Therapy
Constitutive activation of ErbB2 signaling was able to override the functional role of Jak2 in regulating the expression of Akt1 and cyclin D1. [Cancer Res]

Androgen Receptor Inhibits Estrogen Receptor-alpha Activity and is Prognostic in Breast Cancer
Study concludes that by binding a subset of estrogen-responsive elements to an androgen receptor can prevent activation of target genes that mediate the stimulatory effects of 17-beta-estradiol on breast cancer cells. [Cancer Res]

Astrocyte Elevated Gene-1 is a Proliferation Promoter in Breast Cancer Via Suppressing Transcriptional Factor FOXO1
This paper is the first to demonstrate a novel mechanism by which AEG-1 induces proliferation of breast cancer cell, and suggests that AEG-1 might play an important role in tumorigenesis of breast cancer. [Oncogene]

GnRH-II Antagonists Induce Apoptosis in Human Endometrial, Ovarian, and Breast Cancer Cells Via Activation of Stress-Induced MAPKs p38 and JNK and Proapoptotic Protein Bax
This present study ascertained receptor binding and effects of GnRH-II antagonists on mitogenic signal transduction and on activation of proapoptotic protein Bax. [Cancer Res]

Transforming Growth Factor-Beta and Mutant p53 Conspire To Induce Metastasis by Antagonizing p63: A (Ternary) Complex Affair
Two of the key downstream targets of p63 are sufficient as a prognostic tool for breast cancer metastasis. [Breast Cancer Res]

CLINICAL RESEARCH

Uracil-Tegafur and Tamoxifen Vs Cyclophosphamide, Methotrexate, Fluorouracil, and Tamoxifen in Post-Operative Adjuvant Therapy For Stage I, II, or IIIA Lymph Node-Positive Breast Cancer: A Comparative Study
UFT administered in combination with tamoxifen holds promise in the treatment of lymph node-positive early breast cancer. [Br J Cancer]

Breast Center at Moores UCSD Cancer Center Receives National Accreditation
The Breast Center at the Moores UCSD Cancer Center has received accreditation from the National Accreditation Program of Breast Centers, a program administered by the American College of Surgeons.

OVIT Announces Collaboration with MDACC on AdnaGen CTC Assay Development 
OncoVista Innovative Therapies, Inc and AdnaGen AG announced that The University of Texas M. D. Anderson Cancer Center will collaborate on clinical studies of AdnaGen's molecular based CTC technology in Women with High-Risk Locally Advanced Breast Cancer that have completed neoadjuvant and local therapy.

POLICY NEWS

Maryland Slashes Stem Cell Budget by Another $3M in Plan to Trim $700M Budget Deficit
Maryland will cut its stem-cell budget for the fourth time in the past 15 months, as well as eliminate nine positions at its economic development agency, in the first phase of a cost-cutting plan approved Wednesday by Gov. Martin O'Malley.

Canadian Government Reviewing Loan-Program Request For Biotechs
The Canadian government is reviewing a proposal from an organization representing the country's biotech companies to help keep the industry afloat until the economy turns around.

Events

Next Generation Comprehensive Breast Centers of Excellence
September 29-October 2, 2009
Baltimore, MD, United States

2009 National Cancer Research Institute Conference
October 4-7, 2009
Birmingham, United Kingdom

Global Breast Cancer Conference
October 8-10, 2009
Seoul, South Korea

Advances in Breast Cancer Research
October 13-16, 2009
San Diego, CA

32nd Annual CTRC-AACR San Antonio Breast Cancer Symposium
December 9-13, 2009
San Antonio, TX

The 21st Meeting of the European Association for Cancer Research
June 26-29, 2010
Oslo, Norway

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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