In this issue: Science News | Current Publications | Industry News | Policy News  | Events Subscribe | Unsubscribe


TOP STORIES

Drug Attacks Cancer Stem Cells
A compound that appears to target the master cells which help breast cancers grow and spread has been discovered by US scientists. [Whitehead Institute for Biomedical Research, MIT, Massachusetts]

ALDEFLUORBreastCancer_645x110_v02


 
SPECIAL FEATURE

Mammary Stem Cells:  Learn Cutting-Edge, Robust Functional Assays to Evaluate MaSCs 
STEMCELL Technologies is offering a 2-day Mammary Stem Cell Training Course that provides hands-on instruction in the dissection, culture, identification and enumeration of mammary stem and progenitor cells.
October 17-18, 2009, Vancouver, Canada
View Curriculum  /  Register




SCIENCE NEWS

Scientists Find Common Trigger in Cancer and Normal Stem Cell Production
Researchers have discovered a common molecular pathway that is used by both normal stem cells and cancer stem cells when they reproduce themselves. Video [School of Medicine, Stanford University, Palo Alto]

LSUHSC Research Discovers New Targets for Treatment of Invasive Breast Cancer
miR-27b, a novel microRNA, not only inactivates the ST14 gene which they found suppresses the growth of breast tumor cells, but also that miR-27b stimulates the breast cancer to invade other cells. [LSU Health Sciences Center, New Orleans]

Estrogen-Dependent Switch Tempers Killing Activity of Immune Cells
Modulated by estrogen, EBAG9 tempers the activity of Cytotoxic T-cells (CTL). In the absence of EBAG9, the activity of CTLs is enhanced. [Max Delbrück Center for Molecular Medicine, Berlin]

Avastin Plus Commonly Used Chemotherapies Improved Progression-Free Survival (PFS) in Women with Previously Treated Advanced Breast Cancer
Genentech, Inc. today announced that a Phase III study (RIBBON 2) of Avastin® (bevacizumab) in combination with chemotherapy increased the time women with metastatic HER2-negative breast cancer whose initial chemotherapy had stopped working lived without the disease worsening (progression-free survival or PFS), compared to chemotherapy alone. [Genentech Inc., San Francisco]

Study Supports DNA Repair-Blocker Research in Cancer Therapy
Scientists have uncovered the mechanism behind a promising new approach to cancer treatment: damaging cancer cells' DNA with potent drugs while simultaneously preventing the cells from repairing themselves. [Dana-Farber Cancer Institute, Boston]

MammaryCytokines_645x110_v01



CURRENT PUBLICATIONS

LABORATORY RESEARCH

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture. Study demonstrates the ability to identify agents with specific toxicity for epithelial CSCs. [Cell]

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells
The coordinated downregulation of three microRNA clusters and the similar functional regulation of clonal expansion by miR-200c provide a molecular link that connects BCSCs with normal stem cells. [Cell]

A Role for the TGFbeta-Par6 Polarity Pathway in Breast Cancer Progression
Studies reveal a key role for polarity signaling and the control of morphologic transformation in breast cancer metastasis. [PNAS]

Deubiquitinating Enzyme USP33/VDU1 is Required for Slit Signaling in Inhibiting Breast Cancer Cell Migration
Data uncover a previously unknown function of USP33 and reveal a new player in Slit-Robo signaling in cancer cell migration. [PNAS]

CLINICAL RESEARCH

Lower-Dose vs High-Dose Oral Estradiol Therapy of Hormone Receptor-Positive, Aromatase Inhibitor-Resistant Advanced Breast Cancer
In women with advanced breast cancer and acquired resistance to aromatase inhibitors, a daily dose of 6 mg of estradiol provided a similar clinical benefit rate as 30 mg, with fewer serious adverse events. [JAMA]

Conjugated Linoleic Acid Intake and Breast Cancer Risk in a Prospective Cohort of Swedish Women
Results provide no evidence of a protective effect of CLA against breast cancer development in women. [Am J Clin Nutr]

CTR_SS1




INDUSTRY NEWS

Lilly Halts Development of Arzoxifene for Bone Loss
Eli Lilly & Co. halted development of its experimental bone drug arzoxifene after a study found it didn't prevent nonspinal fractures and increased blood clots and hot flashes.



POLICY NEWS

NIH: Francis S. Collins, M.D., Ph.D., Sworn in as NIH Director
He was nominated to lead the NIH, the nation's premiere biomedical research agency, by President Barack Obama on July 8, and was unanimously confirmed by the U.S. Senate on August 7.

FDA: Access to Investigational Drugs




Events

Next Generation Comprehensive Breast Centers of Excellence
September 29-October 2, 2009
Baltimore, MD, United States

2009 National Cancer Research Institute Conference
October 4-7, 2009
Birmingham, United Kingdom

Global Breast Cancer Conference
October 8-10, 2009
Seoul, South Korea

Gordon Research Conference - Stem Cells and Cancer
September 13-18, 2009
Les Diablerets, Switzerland

AACR - Advances in Breast Cancer Research
October 13-16, 2009
San Diego, CA, United States

32nd Annual CTRC - AACR San Antonio Breast Cancer Symposium
December 9-13, 2009
San Antonio, TX

Gordon Research Conference - Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

The 21st Meeting of the European Association for Cancer Research
June 26-29, 2010
Oslo, Norway

Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.


Have we missed an important article or publication in Mammary Cell News? Click here to submit!

 
forwardafriendicon

Learn more about Mammary Cell News: Archives | Events | Update Profile | Contact Us
This email was sent by: Connexon Creative
400-570 W. 7th Avenue Vancouver, British Columbia V5Z 1B3 Canada