Connexon Creative - Mammary Cell News 1.16, September 3rd, 2009

In this issue: Science News | Current Publications | Industry News | Policy News | Events

TOP STORIES

Scientists Identify Gene that Predicts Post-surgical Survival from Brain Metastasis of Breast Cancer Patients
Researchers at the National Cancer Institute have identified a gene that may play a role in breast cancer metastasis to the brain. [Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda]

SPECIAL FEATURE

New! Mammary Epithelial Cell Colony Interactive Tutorial
Explore interactive bi-potent colonies and highlight luminal and basal structures in 3D morphogenesis structures.
Try tutorial now

SCIENCE NEWS

Preventing Breast Cancer: Largest-Ever Review Completed
The largest review of research into lifestyle and breast cancer ever conducted has confirmed that women can reduce their risk by maintaining a healthy weight, being physically active, drinking less alcohol and breastfeeding their children. [American Institute for Cancer Research and World Cancer Research Fund]

NIH Study Reveals New Genetic Culprit in Deadly Skin Cancer
Researchers detected mutations in the ERBB4 gene (also known as HER4) in 19 percent of patients' tumors, making it by far the most frequently mutated protein tyrosine kinase (PTK) gene in melanoma. This discovery is particularly encouraging because ERBB4 is already targeted by a drug approved for certain types of breast cancer. [National Institutes of Health]

Adjuvant Therapy Benefits Breast Cancer Patients with Small Areas of Cancer in Lymph Nodes
Breast cancer patients with very small areas of cancer in the axillary lymph nodes (micrometastases or isolated tumor cells) appear to benefit from post-surgery treatment with chemotherapy, hormonal therapy, or both. [Susan G. Komen for the Cure]

CURRENT PUBLICATIONS

LABORATORY RESEARCH

The Wnt Receptor, Lrp5, is Expressed by Mouse Mammary Stem Cells and is Required to Maintain the Basal Lineage
This is the first single biomarker that has been demonstrated to be functionally involved in stem cell maintenance. Together, these results demonstrate that Wnt signaling through Lrp5 is an important component of normal mammary stem cell function. [PLoS ONE]

Analyses of Resected Human Brain Metastases of Breast Cancer Reveal the Association between Up-Regulation of Hexokinase 2 and Poor Prognosis
Data suggest that HK2 overexpression is associated with metastasis to the brain in breast cancer and it may be a therapeutic target. [Mol Cancer Res]

ErbB4 Splice Variants Cyt1 and Cyt2 Differ by 16 Amino Acids and Exert Opposing Effects on the Mammary Epithelium In Vivo
Results demonstrate that Cyt1 and Cyt2 ErbB4 isoforms, differing by only 16 amino acids, exhibit markedly opposing effects on mammary epithelium growth and differentiation. [Mol Cell Biol]

Analysis of the Tyrosine Kinome in Melanoma Reveals Recurrent Mutations in ERBB4
These studies could lead to personalized therapeutics specifically targeting the kinases that are mutationally altered in individual melanomas. [Nat Genet]

MicroRNAs and Parallel Stem Cell Lives
Certain microRNAs are downregulated in purified populations of normal mammary epithelial stem cells and breast tumor-initiating cells. These findings have important implications for the regulation of self-renewal and differentiation by microRNAs and suggest new ways of targeting cancer stem cells. [Cell]

CLINICAL RESEARCH

Impact of Micrometastases in the Sentinel Node of Patients with Invasive Breast Cancer
Patients with micrometastatic tumor deposits do not seem to have a worse 8-year disease-free survival or overall survival compared with sentinel node-negative patients. [J Clin Oncol]

INDUSTRY NEWS

STEMCELL Technologies Inc. to Host Stem Cell Training Courses
STEMCELL's fall training program includes includes 2-day courses on mesenchymal stem cell biology, mammary stem cell biology, neural stem cell biology, hematopoietic stem cell biology, and human embryonic and induced pluripotent stem cell biology.

FDA Clears Hologic's MammoSite(R) ML Radiation Therapy System For The Treatment Of Early-Stage Breast Cancer
Hologic Inc., today announced the U.S. Food and Drug Administration (FDA) cleared the Company's 510K
application for the MammoSite® ML radiation therapy system.

MOLOGEN Obtains US Patent for Cancer Treatment with Cell-based Gene Therapy
The patent office in the USA has decided to grant MOLOGEN AG the patent for cell-based gene therapy to treat cancer.

POLICY NEWS

Susan G. Komen for the Cure announce the release of the Postdoctoral Fellowship Research grants and Post-Baccalaureate Training in Disparities Research for 2009-2010

NATIONAL INSTITUTES OF HEALTH

New Reporting and Assurance Requirements for Institutions Receiving Awards for Training of Graduate Students for Doctoral Degrees (NOT-OD-09-141)

Request for Applications: 2010 NIH Directors New Innovator Award Program (DP2) (RFA-RM-09-011)

FOOD AND DRUG ADMINISTRATION (United States)

Food and Drug Administration Transparency Task Force; Reopening of Comment Period until November 6, 2009

EVENTS

Next Generation Comprehensive Breast Centers of Excellence
September 29-October 2, 2009
Baltimore, MD, United States

2009 National Cancer Research Institute Conference
October 4-7, 2009
Birmingham, United Kingdom

Global Breast Cancer Conference
October 8-10, 2009
Seoul, South Korea

Gordon Research Conference - Stem Cells and Cancer
September 13-18, 2009
Les Diablerets, Switzerland

AACR - Advances in Breast Cancer Research
October 13-16, 2009
San Diego, CA, United States

32nd Annual CTRC - AACR San Antonio Breast Cancer Symposium
December 9-13, 2009
San Antonio, TX

Gordon Research Conference - Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

The 21st Meeting of the European Association for Cancer Research
June 26-29, 2010
Oslo, Norway

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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