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TOP STORIES

Overexpressed Protein Converts Noninvasive Breast Cancer into Invasive Disease
Active, but non-invasive breast cancer is set free to roam as invasive breast cancer when an overexpressed protein converts it to a different cell type. [M. D. Anderson Cancer Center, University of Texas, Huston]

MammoCult



SPECIAL FEATURE

New! Mammary Epithelial Cell Colony Interactive Tutorial
Explore interactive bi-potent colonies and highlight luminal and basal structures in 3D morphogenesis structures.
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SCIENCE NEWS

Discovery Leads to Rapid Mouse "Personalized Trials" in Breast Cancer
Using a finding that the genetic complexity of tumors in mice parallels that in humans, researchers are starting trial studies in mice, just like human clinical trials, to evaluate whether understanding tumor diversity can improve cancer treatment. [Duke University Institute for Genome Sciences, Durham]

Malignant Signature May Help Identify Patients Likely to Respond to Therapy
A molecular "signature" that helps account for the aggressive behavior of a variety of cancers such as pancreatic, breast and melanoma may also predict the likelihood of successful treatment with a particular anti-cancer drug. [Moores Cancer Center, University of California, San Diego]

HPV Vaccine May Prevent Breast Cancer
Using genetic probes, researchers tested cancerous breast cells and found several strains of HPVs known to have a high risk of initiating cancer of the cervix. HPV has a causal role in 90-95 per cent of cervical cancers. [University of New South Wales, Sydney]

Dissociation Enzymes



CURRENT PUBLICATIONS

LABORATORY RESEARCH

ErbB2 Resembles an Autoinhibited Invertebrate Epidermal Growth Factor Receptor

The orphan receptor tyrosine kinase ErbB2 is the closest structural relative of the single EGF receptor family member in Drosophila melanogaster (dEGFR). [Nature]

14-3-3zeta Cooperates with ErbB2 to Promote Ductal Carcinoma In Situ Progression to Invasive Breast Cancer by Inducing Epithelial-Mesenchymal Transition
Patients whose breast tumors overexpressed both ErbB2 and 14-3-3 had higher rates of metastatic recurrence and death than those whose tumors overexpressed only one. [Cancer Cell]

Identification of a Stat3-Dependent Transcription Regulatory Network Involved in Metastatic Progression
Researchers employed an activated ErbB2 mouse model of breast cancer to investigate the in vivo role of Stat3 in mammary tumor progression and found that Stat3 does not alter mammary tumor initiation but dramatically affects metastatic progression. [Cancer Res]

Therapeutic Targeting of the Focal Adhesion Complex Prevents Oncogenic TGF-Beta Signaling and Metastasis
This study identifies an essential function for FAK in mediating the interaction between beta3 integrin and TBR-II, and thus in facilitating the oncogenic conversion of TGF-beta required for mammary tumor metastasis. [Breast Cancer Res]

Human Papilloma Virus is Associated with Breast Cancer
Observations indicate a likely causal role for high-risk HPV in human breast cancer and offer the possibility of primary prevention of some breast cancers by vaccination against HPV. [Br J Cancer]

CLINICAL RESEARCH

Evaluation of Microtubule-Associated Protein-Tau Expression As a Prognostic and Predictive Marker in the NSABP-B 28 Randomized Clinical Trial
High Tau protein expression is associated with better prognosis in patients treated with adjuvant anthracycline and paclitaxel chemotherapy and endocrine therapy, but there was no significant interaction between Tau expression and paclitaxel benefit. [J Clin Oncol]

Mammary Cytokines




INDUSTRY NEWS

STEMCELL Technologies Inc. to Host Stem Cell Training Courses
STEMCELL's fall training program includes includes 2-day courses on mesenchymal stem cell biology, mammary stem cell biology, neural stem cell biology, hematopoietic stem cell biology, and human embryonic and induced pluripotent stem cell biology.

Axel Ullrich Named Winner of 2009 Dr. Paul Janssen Award for Biomedical Research
Johnson & Johnson today announced that Axel Ullrich, Ph.D., whose discoveries have led to novel cancer therapies including Herceptin® (trastuzumab) , is the winner of the 2009 Dr. Paul Janssen Award for Biomedical Research.

Receptor Logic, Inc. Awarded National Cancer Institute Grant
The grant, entitled "Therapeutic Effectiveness of T Cell Receptor mimic (TCRm™) Antibodies in Breast Cancer Treatment" will accelerate Investigational New Drug Application enabling studies surrounding lead candidate TCRm antibodies.

University of Rochester Researcher Eyes Collagen to Follow Tumor Metastasis
A Medical Center scientist has been awarded a $2 million Era of Hope Scholar Research Award to study how breast cancer cells use collagen fibers to spread, and to investigate whether the process can be predicted and disrupted.



POLICY NEWS

NATIONAL INSTITUTES OF HEALTH (United States)

Clarification of NOT-OD-08-014 Regarding Obtaining Assistance from NIH for Registration and Reporting of Results in ClinicalTrials.gov (NOT-OD-09-147)

Enhancing Peer Review: The NIMH Announces Consolidation of Review Criteria for NIMH Career Opportunities in Research (COR) Honors Undergraduate Research Training Grant (T34) Submitted for FY 2010 Funding (NOT-MH-09-018)




EVENTS

Next Generation Comprehensive Breast Centers of Excellence
September 29-October 2, 2009
Baltimore, MD, United States

2009 National Cancer Research Institute Conference
October 4-7, 2009
Birmingham, United Kingdom

Global Breast Cancer Conference
October 8-10, 2009
Seoul, South Korea

Gordon Research Conference - Stem Cells and Cancer
September 13-18, 2009
Les Diablerets, Switzerland

AACR - Advances in Breast Cancer Research
October 13-16, 2009
San Diego, CA, United States

32nd Annual CTRC - AACR San Antonio Breast Cancer Symposium
December 9-13, 2009
San Antonio, TX

Gordon Research Conference - Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

The 21st Meeting of the European Association for Cancer Research
June 26-29, 2010
Oslo, Norway

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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