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CURRENT PUBLICATIONS
LABORATORY RESEARCH
Astrocyte Elevated Gene-1 is a Proliferation Promoter in Breast Cancer via Suppressing Transcriptional Factor FOXO1
Results provide the first demonstration of a novel mechanism by which AEG-1 induces proliferation of breast cancer cell, and our findings suggest that AEG-1 might play an important role in tumorigenesis of breast cancer. [Oncogene]
The Snf1-Related Kinase, Hunk, is Essential for Mammary Tumor Metastasis
Using targeted deletion in mice, scientists demonstrate that Hunk is required for the metastasis of c-myc-induced mammary tumors, but is dispensable for normal development. [PNAS]
Accelerated Mammary Maturation and Differentiation, and Delayed MMTVneu-Induced Tumorigenesis of K303R Mutant ERAlpha Transgenic Mice
Aberrant estrogenic signaling through the K303R ERAlpha mutation may lead to precocious alveolar budding in virgin mice, and to an expedited maturation and differentiation phenotype in the mammary glands of hormonally stimulated animals. [Oncogene]
An Intra-Ductal Human-In-Mouse Transplantation Model Mimics the Subtypes of Ductal Carcinoma
In Situ
The intra-ductal HIM transplantation model provides an invaluable tool that mimics human breast heterogeneity at the non-invasive stages and allows the study of the distinct molecular and cellular mechanisms of breast cancer progression. [Breast Cancer Res]
Decreased Poly(ADP-Ribosyl)ation of CTCF, a Transcription Factor, is Associated with Breast Cancer Phenotype and Cell Proliferation
Data suggest that the loss of CTCF poly(ADP-ribosyl)ation is associated with cell proliferation and breast tumor development. [Clin Cancer Res]
CLINICAL RESEARCH
Relationship Between Potentially Modifiable Lifestyle Factors and Risk of Second Primary Contralateral Breast Cancer Among Women Diagnosed With Estrogen Receptor-Positive Invasive Breast Cancer
This population-based study adds to the limited available literature and suggests that obesity, smoking, and alcohol consumption influence contralateral breast cancer risk, affording breast cancer survivors three means of potentially reducing this risk. [J Clin Oncol]
Circulating Tumor Cells: A Useful Predictor of Treatment Efficacy in Metastatic Breast Cancer
Scientists provide the first evidence of a strong correlation between circulating tumor cells results and radiographic disease progression in patients receiving chemotherapy or endocrine therapy for metastatic breast cancer. [J Clin Oncol]
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EVENTS
Next Generation Comprehensive Breast Centers of Excellence
September 29-October 2, 2009
Baltimore, MD, United States
2009 National Cancer Research Institute Conference
October 4-7, 2009
Birmingham, United Kingdom
Global Breast Cancer Conference
October 8-10, 2009
Seoul, South Korea
Gordon Research Conference - Stem Cells and Cancer
September 13-18, 2009
Les Diablerets, Switzerland
AACR - Advances in Breast Cancer Research
October 13-16, 2009
San Diego, CA, United States
32nd Annual CTRC - AACR San Antonio Breast Cancer Symposium
December 9-13, 2009
San Antonio, TX
Gordon Research Conference - Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy
The 21st Meeting of the European Association for Cancer Research
June 26-29, 2010
Oslo, Norway
Visit
our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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