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CURRENT PUBLICATIONS
LABORATORY RESEARCH
Mutational Evolution in a Lobular Breast Tumour Profiled at Single Nucleotide Resolution
Recent advances in next generation sequencing have made it possible to precisely characterize all somatic coding mutations that occur during the development and progression of individual breast cancers. [Nature]
Six1 Expands the Mouse Mammary Epithelial Stem/Progenitor Cell Pool and Induces Mammary Tumors that Undergo Epithelial-Mesenchymal Transition
Data provide genetic evidence for a potent oncogenic role for Six1 in mammary epithelial neoplasia, including promotion of EMT and stem cell-like features. [J Clin Invest]
OSU-A9, A Potent Indole-3-Carbinol Derivative, Suppresses Breast Tumor Growth by Targeting the Akt-NF-KappaB Pathway and Stress Response Signaling
OSU-A9 is a potent, orally bioavailable inhibitor of the Akt-NF-B signaling network, targeting multiple aspects of breast tumor pathogenesis and progression. Thus, its translational potential for the treatment or prevention of breast cancer warrants further investigation. [Carcinogenesis]
Isolation of Canine Mammary Cells With Stem Cell Properties and Tumour-Initiating Potential
With the goal of identifying markers for isolating human breast CSCs, researchers have generated a canine model system to isolate and characterize normal and CSCs from dog mammary gland. [Reprod Domest Anim]
CLINICAL RESEARCH
Association Between CYP2D6 Polymorphisms and Outcomes Among Women With Early Stage Breast Cancer Treated With Tamoxifen
Among women with breast cancer treated with tamoxifen, there was an association between CYP2D6 variation and clinical outcomes, such that the presence of 2 functional CYP2D6 alleles was associated with better clinical outcomes and the presence of nonfunctional or reduced-function alleles with worse outcomes. [JAMA]
Phase I Dose Escalation Pharmacokinetic Assessment of Intravenous Humanized Anti-MUC1 Antibody AS1402 in Patients with Advanced Breast Cancer
Repeated iv administration of AS1402 was well tolerated, with a maximum tolerated dose (MTD) exceeding 16 mg/kg, the highest dose administered in this study. [Breast Cancer Res]
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EVENTS
Global Breast Cancer Conference
October 8-10, 2009
Seoul, South Korea
AACR - Advances in Breast Cancer Research
October 13-16, 2009
San Diego, CA, United States
32nd Annual CTRC - AACR San Antonio Breast Cancer Symposium
December 9-13, 2009
San Antonio, TX
Gordon Research Conference - Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy
The 21st Meeting of the European Association for Cancer Research
June 26-29, 2010
Oslo, Norway
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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