Connexon Creative - Mammary Cell News 1.22, October 15th, 2009

In this issue: Science News | Current Publications | Industry News | Policy News | Events

TOP STORIES

New Cancer Gene Discovered
A new cancer gene has been discovered by a research group at the Sahlgrenska Academy. The gene causes an insidious form of glandular cancer in the head, neck and breast in women. [Sahlgrenska Academy, University of Gothenburg, Gothenburg]

SCIENCE NEWS

Hereditary Cancer Diagnosed Earlier
The age at which breast cancer is diagnosed in families that carry harmful BRCA mutations appears to be getting younger in succeeding generations, researchers found. [M.D. Anderson Cancer Center, Houston]

Increased Levels of Müellerian-Inhibiting Substance could Mean Greater Breast Cancer Risk
Women with increased levels of Müllerian inhibiting substance (MIS), best known for regulating in utero sexual differentiation in boys, may be at a greater risk for breast cancer. [Fox Chase Cancer Center, Philadelphia]

CURRENT PUBLICATIONS

LABORATORY RESEARCH

Kinetics of Hyperpolarized 13C1-Pyruvate Transport and Metabolism in Living Human Breast Cancer Cells
Results suggest that hyperpolarized 13C1-pyruvate may be a useful magnetic resonance biomarker of MCT regulation and malignant transformations in breast cancer. [PNAS]

Matrix Density-Induced Mechanoregulation of Breast Cell Phenotype, Signaling and Gene Expression through a FAK-ERK Linkage
Researchers set out to determine whether increased collagen-matrix density, in the absence of stromal cells, was sufficient to promote proliferation and invasion characteristic of a malignant phenotype in non-transformed mammary epithelial cells. [Oncogene]

Complete Focal Adhesion Kinase Deficiency in the Mammary Gland Causes Ductal Dilation and Aberrant Branching Morphogenesis through Defects in Rho Kinase-Dependent Cell Contractility
Data suggest a model in which FAK coordinates contractile forces in mammary epithelial cells to maintain the bilayered cellular organization of myoepithelial and luminal epithelial cells in ducts, thus allowing proper mammary gland development and function. [FASEB J]

Laminin-1 Induces E-Cadherin Expression in 3-Dimensional Cultured Breast Cancer Cells by Inhibiting DNA Methyltransferase 1 and Reversing Promoter Methylation Status
This study determines the role of laminin-1 in promoting metastatic colonization during breast cancer. [FASEB J]

Anticancer Mechanisms of Doxorubicin and Zoledronic Acid in Breast Cancer Tumor Growth in Bone
The researcher's data are the first to show the specific molecular pathways by which sequential treatment with doxorubicin and zoledronic acid induce tumor cell apoptosis and inhibit proliferation in an in vivo model of breast tumor growth in bone. [Mol Cancer Ther]

Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks
Researchers report the pharmacokinetic, efficacy, and mechanism of action studies for the histone deactylase inhibitor vorinostat in a preclinical model of brain metastasis of triple-negative breast cancer. [Clin Cancer Res]

CLINICAL RESEARCH

Prospective Case, Control Study of Serum Müllerian Inhibiting Substance and Breast Cancer Risk
The objective of this study was to determine whether serum MIS levels are associated with breast cancer risk. [J Natl Cancer Inst]

High Intakes of Choline and Betaine Reduce Breast Cancer Mortality in a Population-Based Study
This study suggests that high intake of choline and betaine may be a promising strategy to prevent the development of breast cancer and to reduce its mortality. [FASEB J]

INDUSTRY NEWS

MediGene AG Successfully Completes Patient Recruitment Into Endotag(TM)-1 Phase II Breast Cancer Trial
MediGene AG has successfully completed patient recruitment into its randomized Phase II trial of EndoTAG(TM)-1 for the treatment of triple receptor-negative breast cancer.

European Patent Office to Issue Patent to Phyton Biotech Covering Methods of Making Taxanes - Compounds Useful in Cancer Treatment
Phyton Biotech GmbH reports that the European Patent Office has announced its intention to grant a European patent to Phyton covering methods of producing taxanes such as paclitaxel.

POLICY NEWS

House Energy And Commerce Subcommittee Holds Hearing On Breast Cancer Bills
The House Energy and Commerce Committee Health Subcommittee on Wednesday heard testimony on four bills related to breast cancer detection, prevention and treatment.

Health Care Reform Clears a Senate Hurdle
Historic legislation to expand U.S. health care and control costs won its first Republican supporter Tuesday and cleared a key Senate hurdle, a double-barreled triumph that propelled President Barack Obama's signature issue toward votes this fall in both houses of Congress.

EVENTS

32nd Annual CTRC - AACR San Antonio Breast Cancer Symposium
December 9-13, 2009
San Antonio, TX

NCCN Clinical Practice Guidelines in Oncology Symposium - Breast Cancer
October 19, 2009
Atlanta, GA, United States

Gordon Research Conference - Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

The 21st Meeting of the European Association for Cancer Research
June 26-29, 2010
Oslo, Norway

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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