Connexon Creative - Mammary Cell News 1.24, October 29th, 2009

In this issue: Science News | Current Publications | Industry News | Policy News | Events

TOP STORIES

Alcohol Activates Cellular Changes That Make Tumor Cells Spread
Researchers found that alcohol stimulates what is called the epithelial-to-mesenchymal transition, in which run-of-the-mill cancer cells morph into a more aggressive form and begin to spread throughout the body. [Rush University Medical Center, Chicago]

SPECIAL FEATURE

Video - MammoCult®: Optimized and defined medium for the culture of human mammospheres and tumorspheres

SCIENCE NEWS

Gastroenterologists Explore Relationship between Bacteria in the Gut and Breast Cancer
Researchers are working on a new research study funded by the U.S. Department of Defense to chart the presence of microorganisms found within the gut and to explore how microbial imbalances may impact diseases like breast cancer. [Rush University Medical Center, Chicago]

Moving Images Reveal Secrets Behind Breast Cancer Spread
Scientists have used a cutting edge microscopy technique to identify genes whose activity could be blocked by drugs to stop the spread of the breast cancer. [Tumour Cell Biology Laboratory, London Research Institute]

M. D. Anderson Redefines Screening Guidelines for Breast, Cervical and Colorectal Cancers
The University of Texas M. D. Anderson Cancer Center released today the most comprehensive, risk-based screening guidelines publicly available to date for breast, cervical and colorectal cancers. [M. D. Anderson Cancer Center, Huston]

CURRENT PUBLICATIONS

LABORATORY RESEARCH

p21CIP1 Attenuates Ras- and c-Myc-Dependent Breast Tumor Epithelial Mesenchymal Transition and Cancer Stem Cell-Like Gene Expression In Vivo
Findings establish a link between the loss of p21CIP1 and the acquisition of breast cancer EMT and stem cell properties in vivo. [PNAS]

Capsaicin Causes Cell-Cycle Arrest and Apoptosis in ER-Positive and -Negative Breast Cancer Cells by Modulating the EGFR/HER-2 Pathway
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is an ingredient of chili peppers with inhibitory effects against cancer cells of different origin. Researchers examined the activity of capsaicin on breast cancer cells in vitro and in vivo. [Oncogene]

Upregulation of Lactate Dehydrogenase A by ErbB2 Through Heat Shock Factor 1 Promotes Breast Cancer Cell Glycolysis and Growth
In this study, scientists investigated the role and mechanism of ErbB2 in regulating glycolysis. [Oncogene]

Characterizing the HER2/neu Status and Metastatic Potential of Breast Cancer Stem/Progenitor Cells
Breast cancer stem/progenitor cell populations differ in tumor-initiating potential but are not solely responsible for metastasis. [Ann Surg Oncol]

Phenotypic Knockout of CXCR4 by a Novel Recombinant Protein TAT/54R/KDEL Inhibits Tumors Metastasis
Results suggest that the phenotypic knockout strategy of CXCR4 using a novel recombinant protein TAT/54R/KDEL might be a possible approach for inhibiting relative tumor metastasis mediated by CXCR4/CXCL12 interaction. [Mol Cancer Res]

CLINICAL RESEARCH

Prognostic and Predictive Value of HER2 Extracellular Domain in Metastatic Breast Cancer Treated With Lapatinib and Paclitaxel in a Randomized Phase III Study
Elevated baseline extracellular domain (ECD) level does not predict lapatinib benefit in patients with HER2-negative metastatic breast cancer. Changes in HER2 ECD status correlates with patient outcome regardless of treatment given. [J Clin Oncol]

Phase II Multicenter Trial of Anthracycline Rechallenge With Pegylated Liposomal Doxorubicin (PLD) Plus Cyclophosphamide for First-Line Therapy of Metastatic Breast Cancer Previously Treated With Adjuvant Anthracyclines
PLD plus cyclophosphamide is effective and well tolerated in patients with metastatic breast cancer who have received prior adjuvant anthracycline-containing chemotherapy. The majority of patients experienced a clinical benefit without any significant impact on cardiac function. [J Clin Oncol]

INDUSTRY NEWS

Celldex Therapeutics Presents Positive Clinical Data from Phase 1 Studies of Antibody-Based Cancer Vaccine Candidate, CDX-1307
Celldex Therapeutics, Inc. today announced positive results from Phase 1 studies of CDX-1307 in patients with advanced epithelial cancers, including breast, colon, bladder and pancreatic cancer.

Critical Outcome Technologies Inc. Provides Important Update on COTI-2's Novel Mechanism of Action
Critical Outcome Technologies Inc. provided an important update today regarding the specific cellular target and mechanism of action for the Company's lead oncology candidate, COTI-2.

POLICY NEWS

New EUREKA Awards Fund Highly Innovative Research, Promise Big Payoffs
The National Institutes of Health has awarded 56 grants of up to $67.4 million to support highly innovative research projects that promise big scientific payoffs.

EVENTS

32nd Annual CTRC - AACR San Antonio Breast Cancer Symposium
December 9-13, 2009
San Antonio, TX

NCCN Clinical Practice Guidelines in Oncology Symposium - Breast Cancer
October 19, 2009
Atlanta, GA, United States

Gordon Research Conference - Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

The 21st Meeting of the European Association for Cancer Research
June 26-29, 2010
Oslo, Norway

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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