Connexon Creative - Mammary Cell News 1.25, November 5th, 2009

In this issue: Science News | Current Publications | Industry News | Policy News | Events

TOP STORIES

Experimental Agent Reduces Breast Cancer Metastasis to Bone
Researchers have reduced breast cancer metastasis to bone using an experimental agent to inhibit ROCK, a protein that was found to be over-expressed in metastatic breast cancer. [Tufts University School of Medicine, Medford]

SPECIAL FEATURE

Video - MammoCult®: Optimized and defined medium for the culture of human mammospheres and tumorspheres

SCIENCE NEWS

Early Stage, HER2 Positive Breast Cancer Patients at Increased Risk of Recurrence
Early-stage breast cancer patients with HER2 positive tumors one centimeter or smaller are at significant risk of recurrence of their disease, compared to those with early-stage disease who do not express the aggressive protein. [M. D. Anderson Cancer Center, Houston]

Global Phase III Study Results Show Eribulin Meets Primary Endpoint of Overall Survival
Eisai Inc. today announced preliminary results from a recently completed Phase III study with eribulin mesylate (E7389), discovered and developed by the company, in patients with locally advanced or metastatic breast cancer. [Eisai Inc., Woodcliff Lake]

CURRENT PUBLICATIONS

LABORATORY RESEARCH

Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone
Researchers show that ROCK expression is increased in metastatic human mammary tumors and breast cancer cell lines compared with nonmetastatic tumors and cell lines. [Cancer Res]

Dithiolethione Compounds Inhibit Akt Signaling in Human Breast and Lung Cancer Cells by Increasing PP2A Activity
In this study, researchers show antiproliferative effects of the dithiolethione compound ACS-1 in human cancer cell lines by increasing the activity of the tumor suppressor protein phoshatase 2A (PP2A). [Oncogene]

Repression of SHP-1 Expression by p53 Leads to trkA Tyrosine Phosphorylation and Suppression of Breast Cancer Cell Proliferation
This study investigates the functional relationship between trkA, p53 and SHP-1 in breast-cancer. [Oncogene]

Deletion of PTEN Promotes Tumorigenic Signaling, Resistance to Anoikis, and Altered Response to Chemotherapeutic Agents in Human Mammary Epithelial Cells
To evaluate the biological and clinical relevance of reduced or deleted PTEN expression, a novel in vitro model system was generated using human somatic cell knockout technologies. [Cancer Res]

CLINICAL RESEARCH

High Risk of Recurrence for Patients with Breast Cancer Who have Human Epidermal Growth Factor Receptor 2-Positive, Node-Negative Tumors 1 cm or Smaller
Patients with HER2-positive T1abN0M0 tumors have a significant risk of relapse and should be considered for systemic, anti-HER2, adjuvant therapy. [J Clin Oncol]

Prospective Case-Control Study of Serum Müllerian Inhibiting Substance and Breast Cancer Risk
The objective of this study was to determine whether serum Müllerian Inhibiting Substance (MIS) levels are associated with breast cancer risk. [J Natl Cancer Inst]

INDUSTRY NEWS

Mentor Capital, Inc. Rated a $5/share Speculative Buy on Immune System Breast Cancer Treatment in FDA Phase I/II Trials
Mentor Capital, Inc. is well poised to be a significant participant in the expanding medical sector of Cancer Immunotherapy with a $5 price objective according to Senior Securities Analyst Howard N. Stillman.

POLICY NEWS

Court Refuses to Dismiss Gene Patent Challenge
A federal district court today denied a motion to dismiss a lawsuit challenging patents on the BRCA1 and BRCA2 genes. BRCA1 and BRCA2 are dominant genes that greatly increase the chance of developing breast and ovarian cancer.

National Library of Medicine Podcast: Breast & Prostate Cancer Screening Efficacy
A recent article in the Journal of the American Medical Association suggests screenings for prostate and breast cancer ultimately have not reduced the rates of more serious, invasive cancers and mortality rates.

EVENTS

32nd Annual CTRC - AACR San Antonio Breast Cancer Symposium
December 9-13, 2009
San Antonio, TX

Gordon Research Conference - Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

12th Milan Breast Cancer Conference
June 16-18, 2010
Milan, Italy

The 21st Meeting of the European Association for Cancer Research
June 26-29, 2010
Oslo, Norway

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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