Connexon Creative - Mammary Cell News 1.26, November 12th, 2009

In this issue: Science News | Current Publications | Industry News | Policy News | Events

TOP STORIES

Survival of the Healthiest
An international research team found that potent phenanthridine derived polyADP-ribose polymerase (PARP) inhibitors, efficiently eradicate MCF-7 and MDA231 breast cancer cells without impairing normal proliferating cells. [Sackler School of Medicine, Tel-Aviv University, Tel-Aviv]

SPECIAL FEATURE

Video - MammoCult®: Optimized and defined medium for the culture of human mammospheres and tumorspheres

SCIENCE NEWS

One in Three Breast Cancers Change Form When They Spread
Scientists have discovered that over a third of breast cancer tumours change form when they spread, in results published today in Annals of Oncology online. [Breakthrough Breast Cancer Research Unit, University of Edinburgh, Edinburgh]

Landmark Study in The Lancet Oncology Shows Capecitabine (Xeloda(R)) Combination Therapy Reduces Early Breast Cancer Recurrence
FinXX, a large, Phase III randomised study in women with early breast cancer shows that adding Capecitabine to a treatment regimen containing standard agents allows more women to live cancer-free for longer. [Finnish Breast Cancer Group, Turku]

CURRENT PUBLICATIONS

LABORATORY RESEARCH

A Selective Eradication of Human Nonhereditary Breast Cancer Cells by Phenanthridine-Derived PolyADP-Ribose Polymerase Inhibitors
A recently disclosed alternative mechanism of PARP-1 activation by phosphorylated externally regulated kinase (ERK) implicates PARP-1 in a vast number of signal-transduction networks in the cell. PARP-1 activation was examined for its possible effects on cell proliferation in both normal and malignant cells. [Breast Cancer Res]

p21CIP1 Attenuates Ras- and c-Myc-Dependent Breast Tumor Epithelial Mesenchymal Transition and Cancer Stem Cell-Like Gene Expression In Vivo
Findings establish a link between the loss of p21CIP1 and the acquisition of breast cancer epithelial mesenchymal translation (EMT) and stem cell properties in vivo. [PNAS]

Dynamic Regulation of CD24 and the Invasive, CD44posCD24neg Phenotype in Breast Cancer Cell Lines
Observations suggest that targeted therapy against CD44posCD24neg tumor cells may have limited success in preventing primary tumor metastasis unless Activin/Nodal signaling is arrested. [Breast Cancer Res]

Protein Lysate Microarray Analysis to Identify MicroRNAs Regulating Estrogen Receptor Signaling in Breast Cancer Cell Lines
Researchers present systematic and direct functional evidence of miRNAs inhibiting ERAlpha signaling in breast cancer. [Oncogene]

Synthetic Cannabinoid Receptor Agonists Inhibit Tumor Growth and Metastasis of Breast Cancer
Results indicate that cannabiloid receptors CB1 and CB2 could be used to develop novel therapeutic strategies against breast cancer growth and metastasis. [Mol Cancer Ther]

CLINICAL RESEARCH

Adjuvant Capecitabine in Combination with Docetaxel and Cyclophosphamide plus Epirubicin for Breast Cancer: An Open-Label, Randomised Controlled Trial
The capecitabine-containing chemotherapy regimen reduced breast cancer recurrence compared with a control schedule of standard agents. Capecitabine administration was frequently discontinued because of adverse effects. [Lancet Oncol]

Beta1-Integrin Circumvents the Antiproliferative Effects of Trastuzumab in Human Epidermal Growth Factor Receptor-2-Positive Breast Cancer
Beta1-integrin provides a novel independent prognostic biomarker of trastuzumab response in HER-2-positive MBC patients and suggest a new target to augment the antiproliferative effects of trastuzumab. [Cancer Res]

INDUSTRY NEWS

Abraxis Opens Expanded Plant in Phoenix, Expected to Create 200 Jobs
Abraxis BioScience Inc., a Los Angeles maker of a chemotherapy drug that uses nanoparticles, is continuing its expansion in the Phoenix market.

POLICY NEWS

NIH Awards $27 Million in Recovery Act Funds to Enhance Scientist and Resource Networking
The National Institutes of Health (NIH) today announced awards that will harness the power of social networking to help scientists and students throughout the country accelerate biomedical research.

EVENTS

32nd Annual CTRC - AACR San Antonio Breast Cancer Symposium
December 9-13, 2009
San Antonio, TX

Gordon Research Conference - Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

12th Milan Breast Cancer Conference
June 16-18, 2010
Milan, Italy

The 21st Meeting of the European Association for Cancer Research
June 26-29, 2010
Oslo, Norway

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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