SCIENCE NEWS

Protein from Pregnancy Hormone May Prevent Breast Cancer
Hormones produced during pregnancy induce a protein that directly inhibits the growth of breast cancer.  [Albany Medical College, New York]

New Gene Discovered That Increases the Effectiveness of Drugs Used to Fight Cancer and Allows a Reduction in Dosage
Researchers at the University of Granada have found a suicide gene, called 'gene E', which leads to the death of tumour cells derived from breast, lung and colon cancer, and prevents their growth.  [University of Granada, Granada]

Researchers Identify Role of Gene in Tumor Development, Growth and Progression
Researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis. [Massey Cancer Center, Richmond]

Breast Cancer Research Funding to Establish Effectiveness of Radiotherapy
£160,000 has been granted to study how genes are involved in the effectiveness of radiotherapy treatment for breast cancer.  [Queen's University, Belfast]

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Study shows how collagen crosslinking can modulate tissue fibrosis and stiffness to force focal adhesions, growth factor signaling and breast malignancy. [Cell]

C-Jun Activation is Required for 4-Hydroxytamoxifen-Induced Cell Death in Breast Cancer Cells
Study results indicate that the c-Jun/c-Fos AP-1 complex has a pro-apoptotic role in OHT-treated cancer cells and suggest that pharmacological boosts of c-Jun activation may be useful in a combination therapy setting to sensitize cancer cells to tamoxifen-mediated cell death. [Oncogene]

MBP-1 Inhibits Breast Cancer Growth and Metastasis in Immunocompetent Mice
Study shows that MBP-1 acts as a double-edged sword by inhibiting primary and metastatic tumor growth and modulating matrix metalloproteinase expression with a therapeutic potential against breast cancer progression. [Cancer Res]

Confounding Effects in "A Six-Gene Signature Predicting Breast Cancer Lung Metastasis"
Research shows that the six-gene signature predicts lung metastases of breast tumors independent of the molecular subtypes. [Cancer Res]

Invasion of Human Breast Cancer Cells In vivo Requires Both Paracrine and Autocrine Loops Involving the Colony-Stimulating Factor-1 Receptor
This investigation demonstrates for the first time in vivo that invasion in a human mammary tumor model is dependent on both paracrine signaling with host macrophages as well as autocrine signaling involving the tumor cells themselves. [Cancer Res]

CLINICAL RESEARCH

Circulating Carotenoids, Mammographic Density, and Subsequent Risk of Breast Cancer
Research results suggest that plasma levels of carotenoids may play a role in reducing breast cancer risk, particularly among women with high mammographic density. [Cancer Res]

Prognosis of Women with Metastatic Breast Cancer by HER2 Status and Trastuzumab Treatment: An Institutional-Based Review
Research model suggests that women with HER2/neu-positive disease who received trastuzumab had a 44% reduction in the risk of death compared with women with HER2/neu-negative disease.  [J Clin Oncol]

INDUSTRY NEWS

Cytori Completes Enrollment in International Breast Cancer Reconstruction Study; Interim Data to be Presented Dec. 12 at San Antonio Breast Cancer Symposium
The study is evaluating the use of cell-enriched fat grafting to restore functional and cosmetic deformities in women who have undergone partial mastectomy for early breast cancer.

EVENTS

32nd Annual CTRC - AACR San Antonio Breast Cancer Symposium
December 9-13, 2009
San Antonio, TX

Gordon Research Conference - Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

12th Milan Breast Cancer Conference
June 16-18, 2010
Milan, Italy

The 21st Meeting of the European Association for Cancer Research
June 26-29, 2010
Oslo, Norway

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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