DC-SCRIPT Found To Have Prognostic Value in Breast Cancer
DC-SCRIPT, or dendritic cell-specific transcript, is a key regulator of nuclear receptor activity that may have prognostic value in breast cancer. [Radboud University Nijmegen Medical Centre, Nijmegen]

Novel Detection Method Unmasks Circulating Breast Cancer Cells
Circulating metastatic breast cancer cells can lose their epithelial receptors, a process that enables them to travel through the bloodstream undetected. [The University of Texas M. D. Anderson Cancer Center, Houston]

San Antonio Breast Cancer Symposium: PARP Inhibitor Data Called 'Spectacular'
Treatment with a drug that inhibits DNA repair in cancer cells improved breast cancer patients' survival by almost 60% when added to conventional chemotherapy, according to results from an ongoing study. [Baylor Sammons Cancer Center, Dallas]

The SUMO Modification Pathway is Involved in the BRCA1 Response to Genotoxic Stress
BRCA1 is modified by small ubiquitin-like modifier (SUMO) in response to genotoxic stress, and co-localizes at sites of DNA damage with SUMO1, SUMO2/3 and the SUMO-conjugating enzyme Ubc9. [Nature]

Dual Inactivation of Hus1 and p53 in the Mouse Mammary Gland Results in Accumulation of Damaged Cells and Impaired Tissue Regeneration
Results establish a requirement for Hus1 in the survival and proliferation of mammary epithelium and identify a role for p53 in mammary gland tissue regeneration and homeostasis. [PNAS]

MBP-1 Inhibits Breast Cancer Growth and Metastasis in Immunocompetent Mice
MBP-1 acts as a double-edged sword by inhibiting primary and metastatic tumor growth and modulating matrix metalloproteinase expression with a therapeutic potential against breast cancer progression. [Cancer Res]

Gene Expression Analysis of Macrophages That Facilitate Tumor Invasion Supports a Role for Wnt-Signaling in Mediating Their Activity in Primary Mammary Tumors
Using an in vivo invasion assay, it was demonstrated that invasive carcinoma cells are a unique subpopulation of tumor cells whose invasion and chemotaxis is dependent on the comigration of tumor-associated macrophages. [J Immunol]

Specific Apoptosis Induction by the Dual PI3K/mTOR Inhibitor NVP-BEZ235 in HER2 Amplified and PIK3CA Mutant Breast Cancer Cells
NVP-BEZ235 is a dual PI3K/mTOR inhibitor currently in phase I clinical trials. Researchers profiled this compound against a panel of breast tumor cell lines to identify the patient populations that would benefit from such treatment. [PNAS]

CLINICAL RESEARCH

DC-SCRIPT: Nuclear Receptor Modulation and Prognostic Significance in Primary Breast Cancer
Researchers investigated the role of dendritic cell-specific transcript (DC-SCRIPT) as coregulator of known breast cancer-related nuclear receptors and as a prognostic factor in breast cancer. [J Natl Cancer Inst]

Estrogen Receptor-Alpha Phosphorylation at Serine-118 and Tamoxifen Response in Breast Cancer
Compared with systemically untreated patients, researchers found evidence of a benefit from adjuvant tamoxifen among patients whose tumors had high ERAlphaS118-P expression but not among patients whose tumors had low expression. [J Natl Cancer Inst]

EVENTS

BIT's 3rd Annual World Cancer Congress 2010 - Breast Cancer Conference
April 25-27, 2010
Shanghai, China

IMPAKT Breast Cancer Conference
May 6-8, 2010
Brussels, Belgium

Breast Cancer Research 2010 Conference
May 18, 2010
Middlesex, United Kingdom

Gordon Research Conference: Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

12th Milan Breast Cancer Conference
June 16-18, 2010
Milan, Italy

The 21st Meeting of the European Association for Cancer Research
June 26-29, 2010
Oslo, Norway

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

JOB OPPORTUNITIES

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