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Mammary Cell News 2.14 April 22, 2010. Refer to the archive if you are unable to see images in this email.

In this issue: Science News | Current Publications | Industry News | Policy News | Events

TOP STORY

Scientists Find New Marker to Identify Severe Breast Cancer Cases
Women with breast cancer whose tumors express high levels of a particular genetic marker are significantly more likely to die from their disease than are those with more normal levels, according to researchers. [Press release from Stanford University discussing online prepublication in Nature]

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SCIENCE NEWS

An RNA Clue to Breast Cancer's Spread
Researchers found that a microRNA known as miR-31 is present at unusually low levels in breast cancer tumors that eventually metastasized compared with normal breast cells. [ScienceNow Press Release]

'Fingerprinting' Breast Cancer Cells
Researchers are building a library of synthetically produced antibodies that can detect and rapidly validate proteins secreted by breast cancer cells. [University of Arkansas Press Release]

Breast Cancer Prevention, Raloxifene as Effective as Tamoxifen with Fewer Side Effects
In an update of the 19,490-patient Study of Tamoxifen and Raloxifene (STAR) phase II trial in breast cancer prevention, both raloxifene and tamoxifen remain effective options to prevent breast cancer at 81 months of follow-up. [Press release from American Association for Cancer Research discussing online prepublication in Cancer Prevention Research]

CURRENT PUBLICATIONS

LABORATORY RESEARCH

Genome Remodeling in a Basal-Like Breast Cancer Metastasis and Xenograft
The differential mutation frequencies and structural variation patterns in metastasis and xenograft compared with the primary tumour indicate that secondary tumours may arise from a minority of cells within the primary tumour. [Nature]

Long Non-Coding RNA HOTAIR Reprograms Chromatin State to Promote Cancer Metastasis
Here researchers show that large intervening non-coding RNAs in the HOX loci become systematically dysregulated during breast cancer progression. [Nature]

MicroRNA17/20 Inhibits Cellular Invasion and Tumor Metastasis in Breast Cancer by Heterotypic Signaling
These findings not only reveal an antiinvasive function of microRNA17/20 in breast cancer, but also identify a heterotypic secreted signal that mediates the microRNA regulation of tumor metastasis. [Proc Natl Acad Sci U S A]

Blueberry Phytochemicals Inhibit Growth and Metastatic Potential of MDA-MB-231 Breast Cancer Cells through Modulation of the Phosphatidylinositol 3-Kinase Pathway
This study investigated the chemopreventive activity of blueberry extract in triple-negative breast cancer cell lines in vitro and in vivo. [Cancer Res]

Estrogen Regulation and Physiopathologic Significance of Alternative Promoters in Breast Cancer
To better understand the transcriptomic effect of estrogens, which play a major role in breast cancer, researchers analyzed gene and alternative promoter regulation by estradiol in MCF7 cells using pan-genomic exon arrays. [Cancer Res]

Pituitary Tumor Transforming Gene Binding Factor: a New Gene in Breast Cancer
Because of the presence of putative estrogen response elements in its promoter, researchers assessed pituitary tumor transforming gene binding factor (PBF) regulation by estrogen. [Cancer Res]

Radiofrequency Field-Induced Thermal Cytotoxicity in Cancer Cells Treated with Fluorescent Nanoparticles
Nonionizing radiation, such as radiofrequency field and near infrared laser, induces thermal cytotoxicity in cancer cells treated with gold nanoparticles. [ Cancer]

Malignant Precursor Cells Pre-Exist in Human Breast DCIS and Require Autophagy for Survival
Cytogenetically abnormal spheroid forming, tumorigenic, and invasive neoplastic epithelial cells pre-exist in human ductal carcinoma in situ and require cellular autophagy for survival. [PLoS ONE]

CLINICAL RESEARCH

Association Between Mammographic Density and Age-Related Lobular Involution of the Breast
Researchers examined the involution and density association in a large benign breast disease cohort. [J Clin Oncol]

Prognostic Factors of Survival in the Trastuzumab Era Among Women with Breast Cancer and Brain Metastases Who Receive Whole Brain Radiotherapy
The objective of this study was to review the outcome of women with breast cancer with known receptor status who were treated with whole brain radiotherapy for brain metastases and to determine factors that impact survival. [Cancer]

Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) Phase II Trial: Preventing Breast Cancer
These results have important public health implications and clarify that both raloxifene and tamoxifen are good preventive choices for postmenopausal women with elevated risk for breast cancer. [Cancer Prev Res]

INDUSTRY NEWS

New Preclinical Breast Cancer Study Shows Peregrine's PS-Targeting Antibodies Can Reverse Tumor-Induced Immune Suppression
Peregrine Pharmaceuticals, Inc. reported data from a new preclinical study demonstrating that the company's phosphatidylserine (PS)-targeting antibodies reversed immune suppression by tumors and conferred tumor-specific immunity in models of breast cancer. [Peregrine Pharmaceuticals, Inc. Press Release]

ABRAXANE(R) in Combination with Bevacizumab Shows Promise in New Model of Triple Negative Breast Cancer
Abraxis BioScience, Inc. announced study results that demonstrate a regimen of ABRAXANE(R) given in combination with bevacizumab [Avastin(R)] may have potential in the treatment of triple-negative breast cancers. [Abraxis BioScience, Inc. Press Release]

Einstein Receives $10 Million National Institutes of Health Grant to Expand Stem Cell Research Facilities
Albert Einstein College of Medicine of Yeshiva University has been awarded $10 million from the National Institutes of Health to expand its stem cell research capabilities. [Albert Einstein College of Medicine Press Release]

Apollo Hospitals Group Forays into Stem Cell Research
Apollo Hospitals Educational and Research Centre has set up Cell and Molecular Biology Research Center, which will be involved in stem cell research and clinical trials, in its Jubilee Hills campus. [Apollo Hospitals Group Press Release]

POLICY NEWS

Stem Cell Funding in Sight
Two of the most widely used embryonic stem cell lines could be just weeks away from being eligible for United States federal funding. [Obama Administration, United States]

Patents Block Competition, Slow Innovation in Gene Testing
Exclusive licenses to gene patents, most of which are held by academic institutions and based on taxpayer-funded research, do more to block competition in the gene testing market than to spur the development of new technologies for gauging disease risk. [Duke University Press Release]

Policy Reminder Concerning Appendix Materials for All National Institutes of Health/Agency for Healthcare Research and Quality/National Institute for Occupational Safety and Health Grant Applications (NOT-OD-10-077) [National Institutes of Health, United States]

Enhancing Peer Review: Clarification of Resubmission Policy and Determination of New Application Status (NOT-OD-10-080) [National Institutes of Health, United States]

Guidance on Confirming Appropriate Charges to NIH Awards During Periods of Noncompliance for Activities Involving Animals (NOT-OD-10-081) [National Institutes of Health, United States]

Update of Sample Animal Welfare Assurance for Foreign Institutions (NOT-OD-10-083) [National Institutes of Health, United States]

Agency for Healthcare Research and Quality Small Research Grant Program (R03) (PAR-10-168) [National Institutes of Health, United States]

EVENTS

BIT's 3rd Annual World Cancer Congress 2010 - Breast Cancer Conference
April 25-27, 2010
Shanghai, China

IMPAKT Breast Cancer Conference
May 6-8, 2010
Brussels, Belgium

Breast Cancer Research 2010 Conference
May 18, 2010
London, United Kingdom

American Society of Clinical Oncology (ASCO) Annual Meeting 2010
June 4-8, 2010
Chicago, United States

Gordon Research Conference: Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

12th Milan Breast Cancer Conference
June 16-18, 2010
Milan, Italy

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

The 21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

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