Mesenchymal Cell News 1.03, September 22, 2009. Click here if you are unable to see images in this e-mail.

TOP STORIES

Cytori Reports Preclinical Results that Suggest Adipose-Derived Regenerative Cells may Reverse Peridontal Disease
Cytori Therapeutics reported results from their preclinical study on the use of uncultured adipose-derived regenerative cells (ADRCs) in the treatment of critical periodontal defects in a rat model. The results suggest that the use of ADRCs may reverse the effects of periodontal disease. [Cytori Therapeutics, San Diego]

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SPECIAL FEATURE

Learn to Culture Mesenchymal Stem Cells With The Cell Experts™
STEMCELL Technologies is offering a 2-day Mesenchymal Stem Cell Training Course to provide hands-on instruction in the in the isolation and culture of human and mouse mesenchymal stem cells.
October 2-3, Vancouver, Canada


SCIENCE NEWS

Complimentary Webinar: Defined, Serum-Free Culture of MSCs using MesenCult®-ACF Medium


Researchers at Hohenstein Successfully Colonise a Textile Implant with Human Stem Cells
Researchers have developed a method to embed multipotent mesenchymal stem cells onto the surface fibers of common surgical fabric implants. [Hohenstein Institute, Stuttgart]

Rare Genetic Disease Successfully Reversed Using Stem Cell Transplantation
In research that holds out hope for one day developing a potential therapy to treat the fatal disorder cystinosis, the study shows that the genetic defect in mice can be corrected with stem cell transplantation. [Scripps Research Institute, La Jolla]

Enrolment Complete for Second Group of Heart Failure Patients Treated with "Off-The-Shelf" Adult Stem Cells
Mesoblast Limited, today announced successful completion of enrolment of the second group of 20 patients randomised to receive an increased dose of Revascor™, the proprietary allogeneic, or "off-the-shelf", universal adult stem cell product for congestive heart failure. [Mesoblast Ltd., Melbourne]

Bioheart Inc. Announces Positive Results in the MARVEL Phase II/III Clinical Trial
Bioheart, Inc. recently presented positive efficacy data from part 1 of its Phase II/III clinical trial involving the injection of adult muscle stem cell therapy into patients' damaged heart muscle. [Bioheart Inc., Sunrise]

ALDELUOR



CURRENT PUBLICATIONS

Hepatocyte Growth Factor or Vascular Endothelial Growth Factor Gene Transfer Maximizes Mesenchymal Stem Cell-Based Myocardial Salvage After Acute Myocardial Infarction

Hepatocyte growth factor (HGF) and VEGF are cardioprotective by increasing the tolerance of cardiomyocytes to ischemia, reducing cardiomyocyte apoptosis and increasing prosurvival Akt activation, and MSC-HGF and MSC-VEGF are a valuable source for increased cytokine production and maximize the beneficial effect of MSC-based repair strategies. [Circulation]

Mesenchymal Cell Transplantation and Myocardial Remodeling After Myocardial Infarction
This paper attempted to determine whether and to what degree left ventricular remodeling may be affected by mesenchymal precursor cells injection post-myocardial infarction, and whether these effects are concentration-dependent. [Circulation]

Successful Treatment of the Murine Model of Cystinosis Using Bone Marrow Cell Transplantation
Using the murine model for cystinosis, Ctns-/- mice, researchers performed syngeneic bone marrow cell, hematopoietic stem cell, and mesenchymal stem cell transplantation. [Blood]

Comparison of ex Vivo Expansion Culture Conditions of Mesenchymal Stem Cells for Human Cell Therapy
The aim of this study is to compare the culture of bone marrow-derived MSCs in the presence of different serum supplements to determine the effect on cell growth, differentiation potential, and immunologic function. [Transfusion]

Therapeutic Benefit of Human Umbilical Cord Derived Mesenchymal Stromal Cells in Intracerebral Hemorrhage Rat: Implications of Anti-inflammation and Angiogenesis
Intracerebral administration of UC-MSC could accelerate neurological function recovery of ICH rat, the underlying mechanism may ascribe to their ability to inhibit inflammation and promote angiogenesis.  [Cell Physiol Biochem]

Spontaneous Differentiation of Murine Bone Marrow-Derived Mesenchymal Stem Cells into Adipocytes without Malignant Transformation after Long-Term Culture
Murine bone marrow-derived Mesenchymal Stem Cells (bMSCs) can be propagated in vitro for up to 50 passages with no malignant transformation sign under suitable conditions, but how to sustain their pluripotent potential requires further investigation. [Cell Physiol Biochem]

Cotransplantation with Mesenchymal Stromal Cells Improves Engraftment of Hematopoietic Stem Cells After Autologous Intra-bone marrow Transplantation in Nonhuman Primates
Here, using nonhuman primates, the researchers investigated the effects of cotransplantation with mesenchymal stromal cells on the engraftment of hematopoietic stem cells after autologous intra-bone marrow transplantation. [Exp Hematol]

STEMSOFT




INDUSTRY NEWS

Tulane Enters into Agreement to Produce Adult Stem Cells
Tulane University has announced a cooperative agreement with Repair Technologies, Inc. to develop and manufacture adult stem cells from bone marrow.

Brainstorm Enters into a Strategic Agreement with Harlan Biotech as it Approaches Clinical Trials for ALS
BrainStorm Cell Therapeutics Inc. announced recently that it has entered into a strategic agreement with Harlan Biotech Israel Ltd in order to complete pre-clinical safety experiments for the company's innovative therapy for Amyotrophic Lateral Sclerosis.

Cellular Dynamics International and VivoMedica Launch the CARDIOTOX Consortium to Validate a Human Cardiac Model for Preclinical Cardiotoxicity Testing
Cellular Dynamics International and VivoMedica plc announce the launch of CARDIOTOX - a pharmaceutical industry consortium to validate a human cell model and analysis system for preclinical cardiotoxicity testing of pharmaceutical candidate compounds.

Fluidigm's Upcoming Stem Cell Culture Chip to Speed Development, Reduce Complexity and Lower Costs
This specialized integrated fluidic circuit will enable a variety of cell culture applications, including allowing stem cell researchers to simplify and automate protocols for turning differentiated cells into stem cells, and later fine tuning the reprogramming of those stem cells into targeted differentiated cells.



POLICY NEWS

Elaine Fuchs to Receive National Medal of Science
President Barack Obama announced today that Elaine Fuchs, will receive the National Medal of Science for contributions to the biological sciences.

Californian Stem Cell Agency, Germany Ink Partnership
California's stem cell research funding agency and the German Federal Ministry of Education and Research signed an agreement Thursday that lays the foundation for joint research projects.

Revenue Seen Not Adding Up to Fees
A health-care-overhaul plan from Sen. Max Baucus would assess $123 billion in fees on health insurers, drug and medical-device manufacturers, and medical labs.

FOOD AND DRUG ADMINISTRATION (United States)

Submission of Quality Information for Biotechnology Products in the Office of Biotechnology Products: Extension of Deadlines to Request Participation in Pilot Program and to Submit Applications, etc., 47806-47807 [E9-22378]

Preparation for International Conference on Harmonization; Public Meeting, 47948-47949 [E9-22445]

2009 Biological License Application Approvals

National Institutes of Health (United States)

NIH Opens Website for Human Embryonic Stem Cell Lines for Approval and Announces Members of Working Group




EVENTS

Mesenchymal Stem Cell Conference 2009
November 12-14, 2009, Austin, TX, United States

Molecular Tri Conference & The Stem Cell Meeting
February 2-5, 2010, San Francisco, CA, United States

Blood and Marrow Transplantation
February 24-28, 2010, Orlando, FL, United States

World Congress Regenerative Medicine
March 12-14, 2010, Bangkok, Thailand

The European Group for Blood & Marrow Transplantation Annual Meeting
March 21-24, 2010, Vienna, Austria

9th Transgenic Technology Meeting
March 22-24, 2010, Berlin, Germany


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