TOP STORIES

Stem Cell Study Raises Hope for Bone Repair Pastes
Researchers showed that human stem cells seeded in a tissue engineering scaffolding exhibited "excellent attachment and osteogenic differentiation," which is the process of laying down new bone material.  [University of Maryland Dental School, Baltimore]

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Learn to Culture Mesenchymal Stem Cells With The Cell Experts™
STEMCELL Technologies is offering a 2-day Mesenchymal Stem Cell Training Course to provide hands-on instruction in the in the isolation and culture of human and mouse mesenchymal stem cells.
October 2-3, Vancouver, Canada

SCIENCE NEWS

Complimentary Webinar: Defined, Serum-Free Culture of MSCs using MesenCult®-ACF Medium

Pluristem Therapeutics Doses First Patient in U.S. With Placenta-Derived Stem Cell Product PLX-PAD in a Phase I Clinical Trial for Treatment of Peripheral Artery Disease
Pluristem Therapeutics Inc. recently announced the dosing of the first patient in the U.S. with its placenta-derived stem cell product, PLX-PAD, in a Phase I clinical trial for the treatment of critical limb ischemia. [Pluristem Therapeutics, Haifa]

Surgeons Use Artificial Heart, Stem Cells to Save Patient
A British surgeon saved a dying heart patient by giving him an artificial heart and injecting him with stem cells to rebuild the damaged muscle in a procedure believed to be a world first. [John Radcliffe Hospital, Oxford]

Patients' Legs Saved from Amputation Using Adult Stem Cells
Researchers have treated 33 patients during the Phase I and Phase II safety/efficacy clinical trials using a combination of the patient's own endothelial progenitor cells and mesenchymal stem cells for lower limb ischemia. [TCA Cellular Therapy, Covington]

Experimental Approach May Reverse Rheumatoid Arthritis and Osteoporosis
Researchers have identified a mechanism that may keep a well known signaling molecule from eroding bone and inflaming joints, according to a recent study. [University of Rochester Medical Center, Rochester]

Stem Cells Point to Space Illness
Stem cells exposed to microgravity express different proteins than those grown in normal gravity, say Australian researchers. [University of New South Wales, Sydney]

CURRENT PUBLICATIONS

Mesenchymal Stromal Cells Cross-present Soluble Exogenous Antigens as Part of Their Antigen-presenting Cell Properties
Using an in vitro antigen presentation assay, the researchers demonstrated that murine MSCs can cross-present soluble ovalbumin to naive CD8+ T cells from OT-I mice. [Blood]

Plugging Vascular Leak by Sphingosine Kinase from Bone Marrow Progenitor Cells
This editorial describes several clinical trials that are currently testing the efficacy of bone marrow cell therapy in ischemic tissues. [Circ Res]

Downregulation of GATA-2 and Overexpression of Adipogenic Gene-PPAR?? in Mesenchymal Stem Cells from Patients with Aplastic Anaemia
To elucidate the mechanisms of fatty marrow replacement, the researchers evaluated the mRNA expression for GATA-2 and PPAR?? in mesenchymal stem cells from patients with AA by quantitative real-time PCR. [Exp Hematol]

Mesenchymal stem cell-educated macrophages: A novel type of alternatively activated macrophages
This study investigates the hypothesis that interaction of mesenchymal stem cells with macrophages could play a significant role in their anti-inflammatory/immune modulatory effects. [Exp Hematol]

Effect of 5-azacytidine Induction Duration on Differentiation of Human First-trimester Fetal Mesenchymal Stem Cells Towards Cardiomyocyte-like Cells
The aim of this study is to investigate effects of 5-azacytidine induction duration on differentiation of bone marrow mesenchymal stem cells from human first-trimester abortus towards cardiomyocyte-like cells. [Interact Cardiovasc Thorac Surg]

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INDUSTRY NEWS

Florida Biologix(R) Announces Manufacturing Agreement with America Stem Cell Inc.
America Stem Cell and Florida Biologix team up to get an important cancer therapy to the clinic that can potentially making a life-changing difference for patients with blood-related cancers such as Leukemia, Lymphoma and Myeloma.

BioTime Sets Up Subsidiary in China to Develop Stem Cell Therapeutics
BioTime is setting up an Asian subsidiary based at the Nanshan Memorial Medical Institute in Hong Kong focusing on ophthalmologic, skin, musculoskeletal, and hematologic diseases.

Stem Cell Therapy International, Inc. Announces Merger With Histostem and Launching of AmStem International, Inc.
Terms of the deal called for Stem Cell Therapy to acquire a 90 percent controlling interest in the securities of Histostem, and for Histostem to acquire a 60% controlling interest in the securities of Stem Cell Therapy.

Pitt Researchers Net $5 Million from NIH to Explore Better Ways to Grow Cells for Regenerative Medicine
Regenerative medicine researchers at the University of Pittsburgh received two grants totaling more than $5 million from the National Institutes of Health to explore new methods for cultivating replacement cells from existing tissues and organs.

POLICY NEWS

FOOD AND DRUG ADMINISTRATION (United States)

Von Eschenbach Takes New Job - Trying to Overhaul FDA
Former FDA Commissioner Andrew von Eschenbach has joined Newt Gingrich's health think tank, the Center for Health Transformation, as an adviser.

NIH Clinical Center Testing Automated Cell Expansion System
The ease and security of automation is coming to bone marrow stromal cell expansion in a new machine in the National Institutes of Health Clinical Center's Department of Transfusion Medicine.

THERAPEUTICS GOODS ADMINISTRATION (Australia)

Compliance with Current Standards Applicable to Haematopoietic Progenitor Cells

Presentations About the Regulation of Blood and Tissues

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