TOP STORIES

Heart Disease and Cellular Therapy: Start of Phase III Clinical Trial "PERFECT" Using Autologous CD133+ Bone Marrow Stem Cells
A recent trial aims at determining whether intramyocardial injection of autologous CD133+ bone marrow stem cells improves heart function in addition to coronary artery bypass grafting in patients with chronic ischemic heart disease and reduced pumping function. [Miltenyi Biotec, Bergisch Gladbach]

SCIENCE NEWS

Stem Cell Therapy May Offer Hope for Acute Lung Injury
Researchers have shown that adult stem cells from bone marrow can prevent acute lung injury in a mouse model of the disease. [University of Illinois at Chicago College of Medicine, Chicago]

New Clues to Why Stem Cells Stop Dividing
Scientists have pieced together a mechanism that causes a type of human adult stem cell to permanently stop dividing after being exposed to ionizing radiation. [Lawrence Berkeley National Laboratory, Berkeley]

Hormone Deficiency Shown to Impair Heart Function
Lack of adiponectin, an adipose-derived plasma protein that exerts anti-inflammatory and anti-hypertrophic effects, in aldosterone-induced hypertension worsens left ventricular hypertrophy and heart function in mice. [Boston University School of Medicine, Boston]

Animal Protein-Free Feeder-Independent Maintenance Medium for hESCs & hiPSCs by STEMCELL Technologies     WATCH THE TeSR™2 VIDEO

CURRENT PUBLICATIONS

Development of Stepwise Osteogenesis-mimicking Matrices for the Regulation of Mesenchymal Stem Cell Functions
This study developed matrices mimicking extracellular matrix remodeling during the osteogenesis of mesenchymal stem cells. [J Biol Chem]

MEK, p38, and PI-3K Mediate Cross Talk between EGFR and TNFR in Enhancing Hepatocyte Growth Factor Production from Human Mesenchymal Stem Cells
The experiments described in this report indicate that TGF-{alpha} increases MSC-derived hepatocyte growth factor production. [Am J Physiol Cell Physiol]

Histone Acetyltransferase Cofactor Trrap Is Essential for Maintaining the Hematopoietic Stem/Progenitor Cell Pool
In this study, the researchers identified a role for the histone acetytransferase cofactor Trrap in the maintenance of hematopoietic stem/progenitor cells. [Am J Immunol]

Transplantation with Survivin-engineered Mesenchymal Stem Cells Results in Better Prognosis in a Rat Model of Myocardial Infarction
The researchers in this paper aimed to investigate the effect of survivin-engineered mesenchymal stem cells on post-infarction cardiac performance and remodeling in rats. [Eur J Heart Fail]

The Integrin {alpha}9{beta}1 on Hematopoietic Stem and Progenitor Cells: Involvement in Cell Adhesion, Proliferation and Differentiation
The aim of this study was to gain insight into the expression and functions of the integrin subunits {alpha}7-{alpha}11 within the endosteal stem cell niche. [Haematologica]

Functional Implications of CD34 Expression in Human Adipose-Derived Stem/Progenitor Cells
This paper suggests that CD34 expression in hASCs may correlate with replicative capacity, differentiation potentials, expression profiles of angiogenesis-related genes, and immaturity or stemness of the cells. [Stem Cells Dev]

Umbilical Cord Mesenchymal Stem Cells: Role of Regulatory Genes in Their Differentiation to Osteoblasts
In this study, the researchers describe the gene regulation of umbilical cord mesenchymal stem cells' differentiation to osteogenic, adipogenic, and chondrogenic precursors and demonstrate their tendency to differentiate toward the osteoblast lineage. [Stem Cells Dev]

The Use of a Polyelectrolyte Fibrous Scaffold to Deliver Differentiated hMSCs to the Liver
In this study, an RGD-modified chitosan-alginate polyelectrolyte complex fibrous non-woven scaffold was employed to deliver differentiated human mesenchymal stem cells in vivo. [Biomaterials]

INDUSTRY NEWS 

UCSF Diabetes, Brain Tumor Stem Cell Grants To Drive Development Of Therapies
Two teams of UCSF scientists have received grants from the California Institute for Regenerative Medicine to advance their stem cell based strategies for treating diabetes and brain tumors.

How You Can Store Life-saver for Your Child
A FIRM in Nottingham has become the first in the UK to store tissue as well as blood from babies' umbilical cords.

POLICY NEWS

Risks to Personalized Medicine Seen in U.S. Reform
The federal government's push to control health costs through comparative effectiveness research could threaten strides in personalized medicine.

CIRM, the UK and Canada Award more than $250 Million to Accelerate the Pace of Bringing Stem Cell Therapies to the Clinic
The California Institute for Regenerative Medicine, the state stem cell agency, and two international partners awarded more than $250 million to 14 multidisciplinary teams of researchers in California, the UK and Canada to develop stem cell-based therapies for 11 diseases.

Ontario Targets $25 Million for Stem Cell Research
The Ontario government will announce $25 million for stem cell research as part of an initiative to encourage collaboration among scientists across the province and around the world.

Public Workshop: Emerging Arboviruses: Risk Assessment for Blood, Cell, Tissue and Organ Safety

Springs Man Joins Fight to Allow Compensation for Bone-marrow Donors
Whether bone marrow is classified as an organ, as it's medically classified, or a bodily fluid, is at the heart of a lawsuit by a group hoping to bring more bone marrow donors to the table by being able to compensate them.

EVENTS

Mesenchymal Stem Cell Conference 2009
November 12-14, 2009
Austin, United States

3rd Congress on Non-Hematopoietic Stem Cells
November 20-21, 2009
Tubingen, Germany

Stem Cells World Congress
January 19-20, 2010
San Francisco, United States

Molecular Tri Conference & The Stem Cell Meeting
February 3-5, 2010
San Francisco, United States

2010 Bone Marrow Transplant Tandem Meetings
February 24-28, 2010
Orlando, United States

World Congress Regenerative Medicine
March 12-14, 2010
Bangkok, Thailand

The European Group for Blood & Marrow Transplantation Annual Meeting
March 21-24, 2010
Vienna, Austria

9th Transgenic Technology Meeting
March 22-24, 2010
Berlin, Germany

American Society of Clinical Oncology Annual Meeting
June 4-8, 2010
Chicago, United States

16th Annual ISCT meeting
May 23-26, 2010
Philadelphia, United States

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