TOP STORIES

New Technique Could Revolutionize Stem Cell Transplants
Montreal researchers are taking part in what could become a breakthrough in stem cell transplants, by leading the first transplant of a mismatched donor. [Maisonneuve-Rosemont Hospital, Montreal]

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SCIENCE NEWS

Gene Mismatch Influences Success of Bone Marrow Transplants
A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation, an international team of researchers report. [Broad Institute of MIT and Harvard, Cambridge]

Mercy Gilbert Lead Institution in Stem Cell Trial
Doctors have begun treating first-time heart attack patients using adult stem cells, which they hope will rebuild damaged heart tissue and reduce the risk of heart failure. [Mercy Gilbert Medical Center, Gilbert]

Stem Cell Research Gives Hope for Premature Babies
An Edmonton doctor began injecting stem cells, derived from bone marrow, into the diseased lungs of baby rats and found that the cells prevented further damage. [Royal Alexandra Hospital, Edmonton]

Kiadis Pharma Announces Enrollment of First Patients in a Multinational Registration Study for ATIR™
The study is designed to show reduction in transplant related mortality after one year following an allogeneic stem cell transplantation with a mismatched (haplo-identical) donor in blood cancer patients eligible for an allogeneic stem cell transplantation but without having a matched donor available. [Kiadis Pharma, Amsterdam]

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CURRENT PUBLICATIONS

Coencapsulation of Hepatocytes with Bone Marrow Mesenchymal Stem Cells Improves Hepatocyte-Specific Functions
In this study, the researchers investigated the specific functions of hepatocytes coencapsulated with bone marrow mesenchymal stem cells (MSCs) in vitro, and they further examined whether transplantation of coencapsulated hepatocytes and MSCs could enhance the ability of hepatocytes to alleviate acute liver failure in vivo. [Transplantation]

DNA Methylation Pattern Changes Upon Long-term Culture and Aging of Human Mesenchymal Stromal Cells
Researchers analyzed DNA methylation changes upon long-term culture of mesenchymal stromal cells by using the HumanMethylation27 BeadChip microarray assessing 27 578 unique CpG sites. [Aging Cell]

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Attenuate Hyperoxia-Induced Lung Injury in Neonatal Rats
This study examined whether intratracheal or intraperitoneal transplantation of human umbilical cord blood-derived mesenchymal stem cells can attenuate hyperoxia-induced lung injury in immunocompetent newborn rats. [Cell Transplant]

Amniotic Mesenchymal Tissue Cells Inhibit Dendritic Cell Differentiation of Peripheral Blood and Amnion Resident Monocytes
Researchers demonstrate that the mesenchymal region of human amnion can block differentiation and maturation of monocytes into dendritic cells, preventing the expression of the dendritic cell marker CD1a and reducing the expression of HLA-DR, CD80, and CD83. [Cell Transplant]

Anti-L-NGFR and -CD34 Monoclonal Antibodies Identify Multipotent Mesenchymal Stem Cells in Human Adipose Tissue
In this study, immuno-selected L-NGFR+ and CD34+ subpopulations have been analyzed and compared with the plastic-adherence human adult multipotent stem cells. [Stem Cells Dev]

Transient Receptor Potential Melastatin Type 7 Channel is Critical for the Survival of Bone Marrow Derived Mesenchymal Stem Cells
The transient receptor potential melastatin type 7 channe in mouse mesenchymal stem cells was characterized using molecular biology, immunocytochemistry and patch-clamp. [Stem Cells Dev]

The Effect of VEGF on the Myogenic Differentiation of Adipose Tissue Derived Stem Cells within Thermosensitive Hydrogel Matrices
A combination of human adipose tissue derived stem cells and in vivo gel-forming methoxy poly (ethyleneglycol)-poly (epsilon-caprolactone) (MPEG-PCL) as a muscle regeneration matrix, with and without inclusion of vascular endothelial cell growth factor, was investigated. [Biomaterials]

p53 Regulates the Proliferation, Differentiation and Spontaneous Transformation of Mesenchymal Stem Cells
In this study, researchers investigated the role of p53 in the biology and transformation of murine bone marrow-derived mesenchymal stem cells. [Exp Cell Res]

INDUSTRY NEWS

ReNeuron Awarded Two Grants Under Regenerative Medicine Funding Programme Established by UK Government
ReNeuron Group plc announces that it has been awarded two grants under the Government-backed Technology Strategy Board's Regenerative Medicine Programme.

Kyoto University Granted Patents for Stem Cell Production, Conversion Techniques
A patent for a set of techniques to convert artificially produced stem cells into nerve, muscle and other cell types has been granted to Kyoto University by the Japan Patent Office.

StemCyte Licenses Promising IP for Stem Cell Therapy to Treat Stroke
StemCyte, Inc. concluded an exclusive license and commercialization agreement with Academia Sinica, the National Laboratory of Taiwan, for certain proprietary methods and Intellectual Property related to the treatment of Chronic Stroke with stem cells.

POLICY NEWS

Nebraska Regents Reject Stem Cell Restrictions
The University of Nebraska's Board of Regents took a stand on a controversial issue on Friday, voting down a resolution that would have restricted the amount of stem cell research done in university facilities.

Obama Taps Emory's Wagner for Bioethical Advisory Post
The White House Wednesday announced the formation of a new Presidential Commission for the Study Bioethical Issues and tapped Emory University President James W. Wagner as its vice chairman.

EVENTS

Stem Cells and Regenerative Medicine World Congress
January 20-21, 2010
San Francisco, United States

CHI's Molecular Medicine Tri-Conference 2010
February 3-5, 2010
San Francisco, United States

2010 Bone Marrow Transplant Tandem Meetings
February 24-28, 2010
Orlando, United States

36^th Annual Meeting of the European Group for Blood and Marrow Transplantation
March 21-24, 2010
Vienna, Austria

9th Transgenic Technology Meeting
March 22-24, 2010
Berlin, Germany

4th UK Mesenchymal Stem Cell Meeting
April 14, 2010
Leeds, United Kingdom

2010 American Society of Clinical Oncology Annual Meeting
June 4-8, 2010
Chicago, United States

16th Annual ISCT meeting
May 23-26, 2010
Philadelphia, United States

5^th World Congress on Regenerative Medicine
October 5-7, 2010, 2010
Hannover, Germany

JOB OPPORTUNITIES

Technical Specialist (AABB)

Research & Development Scientist - Mesenchymal Cell Biology (STEMCELL Technologies)

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