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Mesenchymal Cell News 2.25, June 29, 2010. Refer to the archive if you are unable to see images in this email.

In this issue: Science News | Current Publications | Industry News | Policy News | Events

TOP STORY

Epithelial-Mesenchymal Transition-Derived Cells Exhibit Multi-Lineage Differentiation Potential Similar to Mesenchymal Stem Cells

Researchers have demonstrated that the epithelial-to-mesenchymal transition-derived cells are similar to mesenchymal stem cells in gene expression, multi-lineage differentiation, and ability to migrate towards tumor cells and wound sites. [Stem Cells]

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SCIENCE NEWS

Optimal Surgical Procedure for Duodenal Gastrointestinal Stromal Tumors
Gastrointestinal stromal tumors are the most common mesenchymal tumors of the digestive tract. A Switzerland research group has conducted a study to evaluate the outcomes after segmental duodenectomy and pancreaticoduodenectomy. [Press release from EurekAlert! discussing online prepublication in World J Gastroenterol]

Yale Scientists Implant Regenerated Lung Tissue in Rats
A Yale University-led team of scientists reports that it has achieved an important first step in regenerating fully functional lung tissue that can exchange gas. [Press release from Yale University discussing online prepublication in Science]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Reconstituting Organ-Level Lung Functions on a Chip
Here, researchers describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. [Science]

Validated Prediction of Clinical Outcome in Sarcomas and Multiple Types of Cancer on the Basis of a Gene Expression Signature Related to Genome Complexity
Sarcomas are heterogeneous and aggressive mesenchymal tumors. To improve patient grading, researchers performed genomic and expression profiling in a training set of 183 sarcomas and established a prognostic gene expression signature, complexity index in sarcomas (CINSARC), composed of 67 genes related to mitosis and chromosome management. [Nat Med]

Inactivation of Patched1 in the Mouse Limb has Novel Inhibitory Effects on the Chondrogenic Programme
Researchers have conditionally inactivated the hedgehog receptor Ptc1 in undifferentiated limb mesenchyme of the mouse limb using Prx1-Cre, thus inducing constitutively active ligand-independent hedgehog signalling. [J Biol Chem]

Bone Marrow Mesenchymal Stromal Cells Attenuate Organ Injury Induced by LPS and Burn
This work investigates the therapeutic effects of mesenchymal stem cells in injury-models induced by lipopolysaccharide or burn. [Cell Transplant]

Treatment of Ocular Surface Injuries by Limbal and Mesenchymal Stem Cells Growing on Nanofiber Scaffolds
Researchers describe here the growth and metabolic characteristics of mouse limbal stem cells and mesenchymal stem cells growing on 3D nanofiber scaffolds fabricated from polyamide 6/12. [Cell Transplant]

Identification of Target Genes for Wild Type and Truncated HMGA2 in Mesenchymal Stem-Like Cells
To identify pathways that are affected by sarcoma-associated variants of HMGA2, researchers have over-expressed wild type and truncated HMGA2 protein in an immortalized mesenchymal stem-like cell line, and investigated the localisation of these proteins and their effects on differentiation and gene expression patterns. [BMC Cancer]

Extracellular Matrix Produced by Osteoblasts Cultured Under Low-Magnitude, High-Frequency Stimulation is Favourable to Osteogenic Differentiation of Mesenchymal Stem Cells
Researchers investigated the effects of these low-magnitude, high-frequency stimulations mainly on extracellular matrix synthesis. [Calcif Tissue Int]

INDUSTRY NEWS

CIRM Commits $25 Million to Overcome Immune Rejection of Stem Cell Therapies
The Governing Board of the California Institute for Regenerative Medicine, the state stem cell agency created by proposition 71, approved $25 million to fund 19 projects intended to overcome immune rejection of transplanted stem cells. [California Institute for Regenerative Medicine Press Release]

Maryland Stem Cell Research Commission
The Maryland Stem Cell Research Commission will hold a regular meeting. [Maryland Stem Cell Research Commission Press Release]

POLICY NEWS

NICE Unable to Recommend Cancer Drug in Draft Guidance Owing to Lack of Robust Data
In preliminary draft guidance, a new treatment for patients with a form of leukemia has not been recommended for use in the National Health Service (NHS) because evidence does not yet show how well the drug works compared with current NHS treatment, for the price the NHS is being asked to pay. [The National Institute for Health and Clinical Excellence (NICE), United Kingdom]

NIBIB and the Indian Department of Biotechnology Collaborate to Develop Low-Cost Medical Devices
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) announced the availability of supplemental funding for eligible NIBIB-supported research grants to facilitate collaborative work among researchers in the United States and India. [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings [National Institutes of Health, United States]

Development of Articles for Rare Diseases [Food and Drug Administration, United States]

Implementation of the Biologics Price Competition and Innovation Act of 2009 [Food and Drug Administration, United States]

FDA/CDRH Public Meeting: Oversight of Laboratory Developed Tests [Food and Drug Administration, United States]

EVENTS

Worldwide Innovative Networking (WIN) Symposium in Personalized Cancer Medicine
July 7-9, 2010
Paris, France

Translational Cancer Medicine 2010 - USA
July 11-14, 2010
San Francisco, United State

2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore City, Singapore

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

United Kingdom National Stem Cell Network (UKNSCN) 3rd Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

Tissue Engineering & Regenerative Medicine International Society (TERMIS) - Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) - North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

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