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Mesenchymal Cell News 2.33, August 24, 2010. Refer to the archive if you are unable to see images in this email.

In this issue: Science News | Current Publications | Industry News | Policy News | Events

TOP STORY

Human Gingiva-Derived Mesenchymal Stem Cells Elicit Polarization of M2 Macrophages and Enhance Cutaneous Wound Healing

Researchers describe the interplay between gingiva-derived mesenchymal stem cells and macrophages and the potential relevance in skin wound healing. [Stem Cells]

Culture Human Mesenchymal Stem Cells in
Xeno-Free MesenCult^®-XF
by STEMCELL Technologies

WATCH THE WEBINAR

SCIENCE NEWS

New Mechanisms of Tumor Resistance to Targeted Therapy in Lung Cancer are Discovered
Researchers published results of a study that suggests new ways in which tumor cells develop resistance to one of the most successful targeted therapies, the small-molecule drug Tarceva (erlotinib). [Press release from Cold Spring Harbor Laboratory discussing online prepublication in Proceedings of the National Academy of Sciences U.S.A]

Defining Characteristics of Bona Fide Human iPS Cells
Speaker: Sutheera Ratanasirintrawoot, PhD Candidate
G. Daley & T. Schlaeger Labs, Harvard Medical School

WEBINAR: VIEW HERE

CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

TGF-Beta IL-6 Axis Mediates Selective and Adaptive Mechanisms of Resistance to Molecular Targeted Therapy in Lung Cancer
In nonsmall cell lung cancer-derived cell lines and early-stage tumors before erlotinib treatment, researchers have uncovered the existence of a subpopulation of cells that are intrinsically resistant to erlotinib and display features suggestive of epithelial-to-mesenchymal transition. [Proc Natl Acad Sci USA]

Core Epithelial-to-Mesenchymal Transition Interactome Gene-Expression Signature is Associated with Claudin-Low and Metaplastic Breast Cancer Subtypes
The epithelial-to-mesenchymal transition core signature associates closely with the claudin-low and metaplastic breast cancer subtypes and correlates negatively with pathological complete response. [Proc Natl Acad Sci USA]

Novel Hyperactive Transposons for Genetic Modification of Induced Puripotent and Adult Stem Cells: A Non-Viral Paradigm for Coaxed Differentiation
Researchers demonstrate that hyperactive transposases derived from Sleeping Beauty resulted in superior gene transfer efficiencies and expression in mesenchymal and muscle stem/progenitor cells, consistent with higher expression levels of therapeutically relevant proteins including coagulation factor IX. [Stem Cells]

Alpha2B-Adrenoceptor Deficiency Leads to Postnatal Respiratory Failure in Mice
Alpha2B-adrenoceptors in lung epithelia play an important role in suppressing sonic hedgehog-mediated proliferation of mesenchymal cells and thus prevent respiratory failure. [J Biol Chem]

Transplantation of Mesenchymal Stem Cells Exerts a Greater Long-Term Effect Than Bone Marrow Mononuclear Cells in a Chronic Myocardial Infarction Model in Rat
The aim of this study is to assess the long-term effect of mesenchymal stem cells transplantation in a rat model of chronic myocardial infarction in comparison with the effect of bone marrow mononuclear cells transplant. [Cell Transplant]

Tumor Associated Mesenchymal Stem Cells Protects Ovarian Cancer Cells from Hyperthermia through CXCL12
Contrary to the previous published study, researchers demonstrated that TAMC and bone marrow-mesenchymal stem cells co-cultured with ovarian cancer cells induced thermotolerance in a CXCL12 dependant manner. [Int J Cancer]

Fetal and Post-Natal Lung Defects Reveal a Novel and Required Role for Fgf8 in Lung Development
Here, researchers report that Fgf8 function is required for normal progression through the late fetal stages of lung development that culminate in alveolar formation. [Dev Biol]

Dynamic Culture Enhances Stem Cell Infiltration and Modulates Extracellular Matrix Production on Aligned Electrospun Nanofibrous Scaffolds
In this study, researchers demonstrated that a simple modification to standard in vitro culture conditions effectively improves cellular ingress into electrospun scaffolds, resolving a challenge which has until now limited the utility of these materials for various tissue engineering applications. [Acta Biomater]

Osteogenic Differentiation of Human Mesenchymal Stem Cells Synergistically Enhanced by Biomimetic Peptide Amphiphiles Combined with Conditioned Media
In this study, peptide amphiphiles were investigated as an extracellular matrix-mimicking biomaterial to provide an instructive microenvironment for human mesenchymal stem cells in an effort to guide osteogenic differentiation. [Acta Biomater]

Bone Marrow Mesenchymal Stem Cell Transplantation in Patients with Multiple Sclerosis: A Pilot Study
Researchers explore the safety, and therapeutic benefit of intrathecal injection of ex-vivo expanded autologous bone marrow derived mesenchymal stem cells in 10 patients with advanced multiple sclerosis. [J Neuroimmunol]

Rough Surface Topography Enhances the Activation of Wnt/Beta-Catenin Signaling in Mesenchymal Cells
This study analyzed the behavior of the murine C2C12 mesenchymal cell line on polished or acid-etched, sand-blasted commercially pure titanium. [J Biomed Mater Res A]

INDUSTRY NEWS

Stem Cell Agency Commits $243 Million, Expands Team Approach to Developing New Therapies
The Governing Board of the California Institute for Regenerative Medicine, the state stem cell agency created by proposition 71, approved the concept for up to $243 million round of funding to move stem cell-based therapies to clinical trial. [California Institute for Regenerative Medicine Press Release]

NSF Awards $3 Million Stem Cell Bio-Manufacturing Program to Georgia Tech
The National Science Foundation (NSF) has awarded $3 million to the Georgia Institute of Technology to fund a unique research program on stem cell bio-manufacturing. [Georgia Institute of Technology Press Release]

Mesoblast On Track for Phase III Bone Marrow Transplant Trial Following Positive Meeting with FDA
Mesoblast Limited provided market guidance on its Phase III bone marrow transplant program following a formal meeting with the United States Food and Drug Administration (FDA). [Mesoblast Limited Press Release]

Sanofi Seeks Efficiencies with New Model
Sanofi-aventis is dividing its vast resources into decentralized disease-based units, each with its own departments for research and development, regulatory affairs, marketing, and sales -- a plan designed to identify promising drugs more quickly and weed out failures before spending billions on unsuccessful clinical trials. [The Boston Globe]

POLICY NEWS

Lawrence A. Tabak Named Principal Deputy Director NIH
National Institutes of Health Director Francis S. Collins, M.D., Ph.D., announced the appointment of Lawrence A. Tabak, D.D.S., Ph.D., as principal deputy director of the National Institutes of Health. [National Institutes of Health, United States]

FDA, Companies Must Stretch Overseas Supply Oversight
The FDA is trying to stretch its enforcement reach over foreign drug suppliers, potentially through consent decrees, and is asking manufacturers to take bigger steps as well to tighten the pharmaceutical supply chain. [Food and Drug Administration, United States]

Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01) (RFA-GM-11-003) [National Institutes of Health, United States]

Proposed Collection; Comment Request; STAR METRICS--Science and Technology in America's Reinvestment: Measuring the Effects of Research on Innovation, Competitiveness and Science (FR Doc. 2010-20614) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-20287) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20675) [National Institutes of Health, United States]

NIH-RAID Updates on Program Scope and Procedures: Biologics Manufacture, Lead Selection, and Product Development Plans (NOT-RM-10-012) [National Institutes of Health, United States]

Support of National Institute of General Medical Sciences Program Project Grants (P01) (PAR-10-266) [National Institutes of Health, United States]

EVENTS (Listed by Date)

International Society for Cellular Therapy (ISCT) - Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine
September 11-17, 2010
Hydra, Greece

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) - Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th Annual Germany Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

2010 World Stem Cell Summit
October 4-6, 2010
Detroit, United States

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

17th Annual Meeting German Society for Gene Therapy (DG-GT e.V.)
October 6-9, 2010
Munich, Germany

bone-tec 2010 - International Bone-Tissue Engineering Congress
October 7-10, 2010
Hannover, Germany

The NYSCF Fifth Annual Translational Stem Cell Research Conference
October 12-13, 2010
New York, United States

International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference
October 22-24, 2010
Dallas, United States

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

Stem Cell Society Singapore Symposium 2010
November 2-3, 2010
Singapore

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) - North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition (A8)
January 21-26, 2011
Vancouver, Canada

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington DC, United States

Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Keystone, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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